Promoting effect of baicalin on nitric oxide production in CMECs via activating the PI3K-AKT-eNOS pathway attenuates myocardial ischemia–reperfusion injury

Baicalin, which is isolated from Scutellariae Radix, has been shown to possess therapeutic potential for different diseases. Cardiac microvessel injury in myocardial ischemia–reperfusion (IR) has been extensively explored. However, there have been no studies investigating the physiological regulator...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2019-10, Vol.63, p.153035-153035, Article 153035
Hauptverfasser:	Bai, Jiannan, Wang, Qingchao, Qi, Jiaxin, Yu, Hongqiang, Wang, Cong, Wang, Xiaowei, Ren, Yanru, Yang, Fude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Baicalin Cardiac microvascular endothelial cells Cardiotonic Agents - pharmacology Cell Hypoxia Cells, Cultured Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - pathology ENOS Flavonoids - pharmacology Ischemia–reperfusion Male Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Necroptosis Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats, Wistar Signal Transduction - drug effects
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