Bortezomib ameliorates acute allograft rejection after renal transplant by inhibiting Tfh cell proliferation and differentiation via miR-15b/IRF4 axis

The present study aimed to investigate the functional role of bortezomib in the development of acute allograft rejection (AR) after renal transplant. The mouse model of AR was established by allograft kidney transplant followed by the treatment of bortezomib. The serum cytokines, renal function, and...

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Veröffentlicht in:	International immunopharmacology 2019-10, Vol.75, p.105758-105758, Article 105758
Hauptverfasser:	Liu, Lei, Wang, Zhi-gang, Pang, Xin-lu, Feng, Yong-hua, Wang, Jun-xiang, Xie, Hong-chang, Yang, Xian-lei, Li, Jin-feng, Feng, Gui-wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Allograft rejection Allografts Animals Bortezomib Bortezomib - pharmacology Bortezomib - therapeutic use CD4 antigen Cell differentiation Cell Differentiation - drug effects Cell growth Cell proliferation Cell Proliferation - drug effects Cholecystokinin Cytokines Cytokines - blood Differentiation Female Graft rejection Graft Rejection - drug therapy Graft Rejection - immunology Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Interferon Interferon regulatory factor 4 Interferon Regulatory Factors - immunology IRF4 Kidney Transplantation Kinases Lymphocytes Lymphocytes T Male Mice, Inbred BALB C Mice, Inbred C57BL MicroRNAs - immunology miR-15b Proliferation Rejection Renal function T follicular helper cells T-Lymphocytes, Helper-Inducer - drug effects T-Lymphocytes, Helper-Inducer - immunology Therapeutic applications Transfection
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