Miniaturized microscope with flexible light source input for neuronal imaging and manipulation in freely behaving animals

Simultaneous imaging and manipulation of a genetically defined neuronal population can provide a causal link between its activity and function. Here, we designed a miniaturized microscope (or ‘miniscope’) that allows fluorescence imaging and optogenetic manipulation at the cellular level in freely b...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-09, Vol.517 (3), p.520-524
Hauptverfasser:	Srinivasan, Sakthivel, Hosokawa, Takuma, Vergara, Pablo, Chérasse, Yoan, Naoi, Toshie, Sakurai, Takeshi, Sakaguchi, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - physiology CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - ultrastructure Calcium - metabolism Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Dependovirus - genetics Dependovirus - metabolism GCaMP Gene Expression Genes, Reporter Genetic Vectors - chemistry Genetic Vectors - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Hippocampus Injections, Intraventricular Light Mice Microscopy - instrumentation Microscopy - methods Miniaturized microscope Nerve Net - metabolism Nerve Net - ultrastructure Neuroimaging - instrumentation Neuroimaging - methods Neurons - metabolism Neurons - ultrastructure Optical Imaging - instrumentation Optical Imaging - methods Optogenetics Optogenetics - instrumentation Optogenetics - methods Rhodopsin - genetics Rhodopsin - metabolism UCLA miniscope
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