In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database

[Display omitted] •Structure-based pharmacophores screening predicted that mulberrin as the potential candidate SIRT1 activator.•Ligand-based pharmacophores screening predicted that gartanin, quinidine, and quinine are the likely candidates SIRT1 activator.•The MM-GB(PB)SA calculations confirmed tha...

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Veröffentlicht in:	Computational biology and chemistry 2019-12, Vol.83, p.107096-107096, Article 107096
Hauptverfasser:	Azminah, Azminah, Erlina, Linda, Radji, Maksum, Mun’im, Abdul, Syahdi, Rezi Riadhi, Yanuar, Arry
Format:	Artikel
Sprache:	eng
Schlagworte:	Databases, Factual Humans Indonesia Indonesia medicinal plants database (HerbalDB) Molecular Docking Simulation Molecular Dynamics Simulation Pharmacophore-based Plants, Medicinal - chemistry SIRT1 activator Sirtuin 1 - analysis Sirtuin 1 - metabolism Virtual screening
Online-Zugang:	Volltext
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