Vitamin D in migraine headache: a comprehensive review on literature
Introduction As a primary headache, migraine has been established as the first leading disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary supplements have been introduced for migraine complementary treatment. As an anti-inflammatory and antioxidant agent, vi...
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| Veröffentlicht in: | Neurological sciences 2019-12, Vol.40 (12), p.2459-2477 |
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| creator | Ghorbani, Zeinab Togha, Mansoureh Rafiee, Pegah Ahmadi, Zeynab Sadat Rasekh Magham, Reyhaneh Haghighi, Samane Razeghi Jahromi, Soodeh Mahmoudi, Maryam |
| description | Introduction
As a primary headache, migraine has been established as the first leading disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary supplements have been introduced for migraine complementary treatment. As an anti-inflammatory and antioxidant agent, vitamin D is one of these agents which has been of interest in recent years. Although higher prevalence of vitamin D deficiency/insufficiency has been highlighted among migraineurs compared to controls, there is not any consensus in prescribing vitamin D in clinical practice. Therefore, in the current review, in addition to observational and case-control studies, we also included clinical trials concerning the effects of vitamin D supplementation on migraine/headache.
Methods
Based on a PubMed/MEDLINE and ScienceDirect database search, this review study includes published articles up to June 2019 concerning the association between migraine/headache and vitamin D status or supplementation.
Results
The percentage of subjects with vitamin D deficiency and insufficiency among migraineurs and headache patients has been reported to vary between 45 and 100%. In a number of studies, vitamin D level was negatively correlated with frequency of headaches. The present findings show that supplementation with this vitamin in a dose of 1000–4000 IU/d could reduce the frequency of attacks in migraineurs.
Conclusion
It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency. Further, the current evidence shows that in addition to routine drug therapy, vitamin D administration might reduce the frequency of attacks in migraineurs. However, these results have yet to be confirmed. |
| doi_str_mv | 10.1007/s10072-019-04021-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2268575287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2268575287</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-62f9f19d8490dd008b33a36fa324c20c225c1662474a80fd846ee53c961c78aa3</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EolD4AwwoEgtL4GwnscOGWr6kSizAarnOpXXVJMVOiuivx_0AJAaWs6V77rXvIeSMwhUFENd-XVkMNI8hAUbj1R45omkOMU-E3N_dqRRJjxx7PwMAmlB-SHqcciGk4Edk-GZbXdk6GkahVHbitK0xmqIutJniTaQj01QLh1OsvV1i5HBp8SNq6mhuW3S67RyekINSzz2e7s4-eb2_exk8xqPnh6fB7Sg2XKRtnLEyL2leyCSHogCQY841z0rNWWIYGMZSQ7OMJSLREsrAZYgpN3lGjZBa8z653OYuXPPeoW9VZb3B-VzX2HReMZbJVKQsbNYnF3_QWdO5OvxuQ1EIoAwU21LGNd47LNXC2Uq7T0VBre2qrWMVHKuNY7UKQ-e76G5cYfEz8i01AHwL-NCqJ-h-3_4n9gvRdIWY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2268108578</pqid></control><display><type>article</type><title>Vitamin D in migraine headache: a comprehensive review on literature</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ghorbani, Zeinab ; Togha, Mansoureh ; Rafiee, Pegah ; Ahmadi, Zeynab Sadat ; Rasekh Magham, Reyhaneh ; Haghighi, Samane ; Razeghi Jahromi, Soodeh ; Mahmoudi, Maryam</creator><creatorcontrib>Ghorbani, Zeinab ; Togha, Mansoureh ; Rafiee, Pegah ; Ahmadi, Zeynab Sadat ; Rasekh Magham, Reyhaneh ; Haghighi, Samane ; Razeghi Jahromi, Soodeh ; Mahmoudi, Maryam</creatorcontrib><description>Introduction
As a primary headache, migraine has been established as the first leading disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary supplements have been introduced for migraine complementary treatment. As an anti-inflammatory and antioxidant agent, vitamin D is one of these agents which has been of interest in recent years. Although higher prevalence of vitamin D deficiency/insufficiency has been highlighted among migraineurs compared to controls, there is not any consensus in prescribing vitamin D in clinical practice. Therefore, in the current review, in addition to observational and case-control studies, we also included clinical trials concerning the effects of vitamin D supplementation on migraine/headache.
Methods
Based on a PubMed/MEDLINE and ScienceDirect database search, this review study includes published articles up to June 2019 concerning the association between migraine/headache and vitamin D status or supplementation.
Results
The percentage of subjects with vitamin D deficiency and insufficiency among migraineurs and headache patients has been reported to vary between 45 and 100%. In a number of studies, vitamin D level was negatively correlated with frequency of headaches. The present findings show that supplementation with this vitamin in a dose of 1000–4000 IU/d could reduce the frequency of attacks in migraineurs.
Conclusion
It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency. Further, the current evidence shows that in addition to routine drug therapy, vitamin D administration might reduce the frequency of attacks in migraineurs. However, these results have yet to be confirmed.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-019-04021-z</identifier><identifier>PMID: 31377873</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antioxidants ; Clinical trials ; Dietary Supplements ; Drug therapy ; Headache ; Headaches ; Humans ; Inflammation ; Medicine ; Medicine & Public Health ; Migraine ; Migraine Disorders - drug therapy ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Nutrient deficiency ; Patients ; Psychiatry ; Review Article ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - pharmacology ; Vitamin deficiency</subject><ispartof>Neurological sciences, 2019-12, Vol.40 (12), p.2459-2477</ispartof><rights>Fondazione Società Italiana di Neurologia 2019</rights><rights>Neurological Sciences is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-62f9f19d8490dd008b33a36fa324c20c225c1662474a80fd846ee53c961c78aa3</citedby><cites>FETCH-LOGICAL-c375t-62f9f19d8490dd008b33a36fa324c20c225c1662474a80fd846ee53c961c78aa3</cites><orcidid>0000-0003-3656-2390</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-019-04021-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-019-04021-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31377873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghorbani, Zeinab</creatorcontrib><creatorcontrib>Togha, Mansoureh</creatorcontrib><creatorcontrib>Rafiee, Pegah</creatorcontrib><creatorcontrib>Ahmadi, Zeynab Sadat</creatorcontrib><creatorcontrib>Rasekh Magham, Reyhaneh</creatorcontrib><creatorcontrib>Haghighi, Samane</creatorcontrib><creatorcontrib>Razeghi Jahromi, Soodeh</creatorcontrib><creatorcontrib>Mahmoudi, Maryam</creatorcontrib><title>Vitamin D in migraine headache: a comprehensive review on literature</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Introduction
As a primary headache, migraine has been established as the first leading disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary supplements have been introduced for migraine complementary treatment. As an anti-inflammatory and antioxidant agent, vitamin D is one of these agents which has been of interest in recent years. Although higher prevalence of vitamin D deficiency/insufficiency has been highlighted among migraineurs compared to controls, there is not any consensus in prescribing vitamin D in clinical practice. Therefore, in the current review, in addition to observational and case-control studies, we also included clinical trials concerning the effects of vitamin D supplementation on migraine/headache.
Methods
Based on a PubMed/MEDLINE and ScienceDirect database search, this review study includes published articles up to June 2019 concerning the association between migraine/headache and vitamin D status or supplementation.
Results
The percentage of subjects with vitamin D deficiency and insufficiency among migraineurs and headache patients has been reported to vary between 45 and 100%. In a number of studies, vitamin D level was negatively correlated with frequency of headaches. The present findings show that supplementation with this vitamin in a dose of 1000–4000 IU/d could reduce the frequency of attacks in migraineurs.
Conclusion
It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency. Further, the current evidence shows that in addition to routine drug therapy, vitamin D administration might reduce the frequency of attacks in migraineurs. However, these results have yet to be confirmed.</description><subject>Antioxidants</subject><subject>Clinical trials</subject><subject>Dietary Supplements</subject><subject>Drug therapy</subject><subject>Headache</subject><subject>Headaches</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Migraine</subject><subject>Migraine Disorders - drug therapy</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Nutrient deficiency</subject><subject>Patients</subject><subject>Psychiatry</subject><subject>Review Article</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - pharmacology</subject><subject>Vitamin deficiency</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kD1PwzAQhi0EolD4AwwoEgtL4GwnscOGWr6kSizAarnOpXXVJMVOiuivx_0AJAaWs6V77rXvIeSMwhUFENd-XVkMNI8hAUbj1R45omkOMU-E3N_dqRRJjxx7PwMAmlB-SHqcciGk4Edk-GZbXdk6GkahVHbitK0xmqIutJniTaQj01QLh1OsvV1i5HBp8SNq6mhuW3S67RyekINSzz2e7s4-eb2_exk8xqPnh6fB7Sg2XKRtnLEyL2leyCSHogCQY841z0rNWWIYGMZSQ7OMJSLREsrAZYgpN3lGjZBa8z653OYuXPPeoW9VZb3B-VzX2HReMZbJVKQsbNYnF3_QWdO5OvxuQ1EIoAwU21LGNd47LNXC2Uq7T0VBre2qrWMVHKuNY7UKQ-e76G5cYfEz8i01AHwL-NCqJ-h-3_4n9gvRdIWY</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Ghorbani, Zeinab</creator><creator>Togha, Mansoureh</creator><creator>Rafiee, Pegah</creator><creator>Ahmadi, Zeynab Sadat</creator><creator>Rasekh Magham, Reyhaneh</creator><creator>Haghighi, Samane</creator><creator>Razeghi Jahromi, Soodeh</creator><creator>Mahmoudi, Maryam</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3656-2390</orcidid></search><sort><creationdate>20191201</creationdate><title>Vitamin D in migraine headache: a comprehensive review on literature</title><author>Ghorbani, Zeinab ; Togha, Mansoureh ; Rafiee, Pegah ; Ahmadi, Zeynab Sadat ; Rasekh Magham, Reyhaneh ; Haghighi, Samane ; Razeghi Jahromi, Soodeh ; Mahmoudi, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-62f9f19d8490dd008b33a36fa324c20c225c1662474a80fd846ee53c961c78aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antioxidants</topic><topic>Clinical trials</topic><topic>Dietary Supplements</topic><topic>Drug therapy</topic><topic>Headache</topic><topic>Headaches</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Migraine</topic><topic>Migraine Disorders - drug therapy</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Nutrient deficiency</topic><topic>Patients</topic><topic>Psychiatry</topic><topic>Review Article</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - pharmacology</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghorbani, Zeinab</creatorcontrib><creatorcontrib>Togha, Mansoureh</creatorcontrib><creatorcontrib>Rafiee, Pegah</creatorcontrib><creatorcontrib>Ahmadi, Zeynab Sadat</creatorcontrib><creatorcontrib>Rasekh Magham, Reyhaneh</creatorcontrib><creatorcontrib>Haghighi, Samane</creatorcontrib><creatorcontrib>Razeghi Jahromi, Soodeh</creatorcontrib><creatorcontrib>Mahmoudi, Maryam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghorbani, Zeinab</au><au>Togha, Mansoureh</au><au>Rafiee, Pegah</au><au>Ahmadi, Zeynab Sadat</au><au>Rasekh Magham, Reyhaneh</au><au>Haghighi, Samane</au><au>Razeghi Jahromi, Soodeh</au><au>Mahmoudi, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D in migraine headache: a comprehensive review on literature</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>40</volume><issue>12</issue><spage>2459</spage><epage>2477</epage><pages>2459-2477</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Introduction
As a primary headache, migraine has been established as the first leading disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary supplements have been introduced for migraine complementary treatment. As an anti-inflammatory and antioxidant agent, vitamin D is one of these agents which has been of interest in recent years. Although higher prevalence of vitamin D deficiency/insufficiency has been highlighted among migraineurs compared to controls, there is not any consensus in prescribing vitamin D in clinical practice. Therefore, in the current review, in addition to observational and case-control studies, we also included clinical trials concerning the effects of vitamin D supplementation on migraine/headache.
Methods
Based on a PubMed/MEDLINE and ScienceDirect database search, this review study includes published articles up to June 2019 concerning the association between migraine/headache and vitamin D status or supplementation.
Results
The percentage of subjects with vitamin D deficiency and insufficiency among migraineurs and headache patients has been reported to vary between 45 and 100%. In a number of studies, vitamin D level was negatively correlated with frequency of headaches. The present findings show that supplementation with this vitamin in a dose of 1000–4000 IU/d could reduce the frequency of attacks in migraineurs.
Conclusion
It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency. Further, the current evidence shows that in addition to routine drug therapy, vitamin D administration might reduce the frequency of attacks in migraineurs. However, these results have yet to be confirmed.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31377873</pmid><doi>10.1007/s10072-019-04021-z</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0003-3656-2390</orcidid></addata></record> |
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| subjects | Antioxidants Clinical trials Dietary Supplements Drug therapy Headache Headaches Humans Inflammation Medicine Medicine & Public Health Migraine Migraine Disorders - drug therapy Neurology Neuroradiology Neurosciences Neurosurgery Nutrient deficiency Patients Psychiatry Review Article Vitamin D Vitamin D - administration & dosage Vitamin D - pharmacology Vitamin deficiency |
| title | Vitamin D in migraine headache: a comprehensive review on literature |
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