Efficacy of immune checkpoint blockade in MUTYH-associated hereditary colorectal cancer

Summary Colorectal carcinomas (CRCs) caused by hereditary biallelic MUTYH gene mutations are characterized by elevated mutation load and high lymphocyte infiltration. Given that these tumor features are associated with the response to immune checkpoint inhibitors, we administered nivolumab to a CRC...

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Veröffentlicht in:	Investigational new drugs 2020-06, Vol.38 (3), p.894-898
Hauptverfasser:	Volkov, Nikita M., Yanus, Grigoriy A., Ivantsov, Alexandr O., Moiseenko, Fedor V., Matorina, Olga G., Bizin, Ilya V., Moiseyenko, Vladimir M., Imyanitov, Evgeny N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Chemotherapy Colorectal cancer Colorectal carcinoma Immune checkpoint inhibitors Infiltration Invasiveness Lymphocytes Medicine Medicine & Public Health Metastases Microsatellite instability Monoclonal antibodies Mutation Oncology Pharmacology/Toxicology Short Report Stability Targeted cancer therapy Tumors
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