The quaternary structure of insulin glargine and glulisine under formulation conditions

The quaternary structures of insulin glargine and glulisine under formulation conditions and upon dilution using placebo or water were investigated using synchrotron small-angle X-ray scattering. Our results revealed that insulin glulisine in Apidra® is predominantly hexameric in solution with signi...

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Veröffentlicht in:	Biophysical chemistry 2019-10, Vol.253, p.106226-106226, Article 106226
Hauptverfasser:	Nagel, Norbert, Graewert, Melissa A., Gao, Mimi, Heyse, Winfried, Jeffries, Cy M., Svergun, Dmitri, Berchtold, Harald
Format:	Artikel
Sprache:	eng
Schlagworte:	Glargine Glulisine Insulin Quaternary structure SAXS
Online-Zugang:	Volltext
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