Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen
To determine the required hepatitis B vaccine doses for subjects who were seronegative for three hepatitis B seromarkers during their youth who wish to have seroprotective antibodies against the hepatitis B surface antigen (anti-HBs). We conducted a retrospective cohort study. From 2012 to 2015, gra...
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| Veröffentlicht in: | Family practice 2020-02, Vol.37 (1), p.30-35 |
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| creator | Jan, Chyi-Feng Liu, Tzu-Hung Ho, Chien-Han Chien, Yin-Chu Chang, Che-Jui Guo, Fei-Ran Huang, Kuo-Chin |
| description | To determine the required hepatitis B vaccine doses for subjects who were seronegative for three hepatitis B seromarkers during their youth who wish to have seroprotective antibodies against the hepatitis B surface antigen (anti-HBs).
We conducted a retrospective cohort study. From 2012 to 2015, graduate school students born after 1986 who were seronegative for three hepatitis B virus seromarkers at college entrance (n = 1037) were recruited. Four groups of subjects received zero to three doses of a hepatitis B vaccine booster at their free willingness, and their anti-HBs titre were measured at their graduate school entrance. Very low and extremely low antibody titres against the hepatitis B surface antigen were elucidated by graphic inference to determine the required booster dose cut-off value for seropositivity after revaccination.
The anti-HBs seropositive rates in the four groups of subjects receiving the hepatitis B booster vaccine(s) were 17.7%, 52.1%, 78.6% and 90.9% for those receiving zero, one, two and three doses, respectively. In subjects with very low antibody titres against the hepatitis B surface antigen after one dose of the vaccine booster and subjects with an extremely low titre after two doses of the booster, the seropositive rates reached 95% at the cut-off value of 3 mIU/ml.
A seropositive rate of at least 95% can be reached by the administration of two hepatitis B booster doses to youths with extremely low antibody titres against the hepatitis B surface antigen ( |
| doi_str_mv | 10.1093/fampra/cmz039 |
| format | Article |
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We conducted a retrospective cohort study. From 2012 to 2015, graduate school students born after 1986 who were seronegative for three hepatitis B virus seromarkers at college entrance (n = 1037) were recruited. Four groups of subjects received zero to three doses of a hepatitis B vaccine booster at their free willingness, and their anti-HBs titre were measured at their graduate school entrance. Very low and extremely low antibody titres against the hepatitis B surface antigen were elucidated by graphic inference to determine the required booster dose cut-off value for seropositivity after revaccination.
The anti-HBs seropositive rates in the four groups of subjects receiving the hepatitis B booster vaccine(s) were 17.7%, 52.1%, 78.6% and 90.9% for those receiving zero, one, two and three doses, respectively. In subjects with very low antibody titres against the hepatitis B surface antigen after one dose of the vaccine booster and subjects with an extremely low titre after two doses of the booster, the seropositive rates reached 95% at the cut-off value of 3 mIU/ml.
A seropositive rate of at least 95% can be reached by the administration of two hepatitis B booster doses to youths with extremely low antibody titres against the hepatitis B surface antigen (<3 mIU/ml) and administering one dose to those with very low titres (3-10 mIU/ml) at college.</description><identifier>ISSN: 1460-2229</identifier><identifier>EISSN: 1460-2229</identifier><identifier>DOI: 10.1093/fampra/cmz039</identifier><identifier>PMID: 31375819</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Cohort Studies ; Female ; Hepatitis B - immunology ; Hepatitis B - prevention & control ; Hepatitis B Antibodies - immunology ; Hepatitis B Surface Antigens - immunology ; Hepatitis B Vaccines - administration & dosage ; Hepatitis B Vaccines - immunology ; Humans ; Immunization, Secondary - methods ; Male ; Retrospective Studies ; Taiwan ; Young Adult</subject><ispartof>Family practice, 2020-02, Vol.37 (1), p.30-35</ispartof><rights>The Author(s) 2019. Published by Oxford University Press.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c288t-1629015ba0a59f6d976196d4b01a6e98fdf0768f2ca4ca29532967424c362fc43</cites><orcidid>0000-0003-2893-2187</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31375819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jan, Chyi-Feng</creatorcontrib><creatorcontrib>Liu, Tzu-Hung</creatorcontrib><creatorcontrib>Ho, Chien-Han</creatorcontrib><creatorcontrib>Chien, Yin-Chu</creatorcontrib><creatorcontrib>Chang, Che-Jui</creatorcontrib><creatorcontrib>Guo, Fei-Ran</creatorcontrib><creatorcontrib>Huang, Kuo-Chin</creatorcontrib><title>Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen</title><title>Family practice</title><addtitle>Fam Pract</addtitle><description>To determine the required hepatitis B vaccine doses for subjects who were seronegative for three hepatitis B seromarkers during their youth who wish to have seroprotective antibodies against the hepatitis B surface antigen (anti-HBs).
We conducted a retrospective cohort study. From 2012 to 2015, graduate school students born after 1986 who were seronegative for three hepatitis B virus seromarkers at college entrance (n = 1037) were recruited. Four groups of subjects received zero to three doses of a hepatitis B vaccine booster at their free willingness, and their anti-HBs titre were measured at their graduate school entrance. Very low and extremely low antibody titres against the hepatitis B surface antigen were elucidated by graphic inference to determine the required booster dose cut-off value for seropositivity after revaccination.
The anti-HBs seropositive rates in the four groups of subjects receiving the hepatitis B booster vaccine(s) were 17.7%, 52.1%, 78.6% and 90.9% for those receiving zero, one, two and three doses, respectively. In subjects with very low antibody titres against the hepatitis B surface antigen after one dose of the vaccine booster and subjects with an extremely low titre after two doses of the booster, the seropositive rates reached 95% at the cut-off value of 3 mIU/ml.
A seropositive rate of at least 95% can be reached by the administration of two hepatitis B booster doses to youths with extremely low antibody titres against the hepatitis B surface antigen (<3 mIU/ml) and administering one dose to those with very low titres (3-10 mIU/ml) at college.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B Antibodies - immunology</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>Hepatitis B Vaccines - administration & dosage</subject><subject>Hepatitis B Vaccines - immunology</subject><subject>Humans</subject><subject>Immunization, Secondary - methods</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Taiwan</subject><subject>Young Adult</subject><issn>1460-2229</issn><issn>1460-2229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOwzAQRS0EoqWwZIu8ZBPqR-LES94gVWID68hxxq1REwfbQSpfwGcTmoJgNaO5R3ekg9ApJReUSD43qum8muvmg3C5h6Y0FSRhjMn9P_sEHYXwSgjJ8yw_RBNOeZ4VVE7R540LELAzeAWdijbagK-wh3eltW2Hg2txC1BDjY3zOK4AB_CuheWQvQPeuD6uAo4OV2PSuWC3yXBSbbSVqzdYLZVtQ_z3I_TeKA1baAntMTowah3gZDdn6OXu9vn6IVk83T9eXy4SzYoiJlQwSWhWKaIyaUQtc0GlqNOKUCVAFqY2JBeFYVqlWjGZcSZFnrJUc8GMTvkMnY-9nXdvPYRYNjZoWK9VC64PJWOi4JSlGRvQZES1dyF4MGXnbaP8pqSk_JZfjvLLUf7An-2q-6qB-pf-sc2_AOFRhGY</recordid><startdate>20200219</startdate><enddate>20200219</enddate><creator>Jan, Chyi-Feng</creator><creator>Liu, Tzu-Hung</creator><creator>Ho, Chien-Han</creator><creator>Chien, Yin-Chu</creator><creator>Chang, Che-Jui</creator><creator>Guo, Fei-Ran</creator><creator>Huang, Kuo-Chin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2893-2187</orcidid></search><sort><creationdate>20200219</creationdate><title>Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen</title><author>Jan, Chyi-Feng ; Liu, Tzu-Hung ; Ho, Chien-Han ; Chien, Yin-Chu ; Chang, Che-Jui ; Guo, Fei-Ran ; Huang, Kuo-Chin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-1629015ba0a59f6d976196d4b01a6e98fdf0768f2ca4ca29532967424c362fc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B - prevention & control</topic><topic>Hepatitis B Antibodies - immunology</topic><topic>Hepatitis B Surface Antigens - immunology</topic><topic>Hepatitis B Vaccines - administration & dosage</topic><topic>Hepatitis B Vaccines - immunology</topic><topic>Humans</topic><topic>Immunization, Secondary - methods</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Taiwan</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jan, Chyi-Feng</creatorcontrib><creatorcontrib>Liu, Tzu-Hung</creatorcontrib><creatorcontrib>Ho, Chien-Han</creatorcontrib><creatorcontrib>Chien, Yin-Chu</creatorcontrib><creatorcontrib>Chang, Che-Jui</creatorcontrib><creatorcontrib>Guo, Fei-Ran</creatorcontrib><creatorcontrib>Huang, Kuo-Chin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Family practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jan, Chyi-Feng</au><au>Liu, Tzu-Hung</au><au>Ho, Chien-Han</au><au>Chien, Yin-Chu</au><au>Chang, Che-Jui</au><au>Guo, Fei-Ran</au><au>Huang, Kuo-Chin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen</atitle><jtitle>Family practice</jtitle><addtitle>Fam Pract</addtitle><date>2020-02-19</date><risdate>2020</risdate><volume>37</volume><issue>1</issue><spage>30</spage><epage>35</epage><pages>30-35</pages><issn>1460-2229</issn><eissn>1460-2229</eissn><abstract>To determine the required hepatitis B vaccine doses for subjects who were seronegative for three hepatitis B seromarkers during their youth who wish to have seroprotective antibodies against the hepatitis B surface antigen (anti-HBs).
We conducted a retrospective cohort study. From 2012 to 2015, graduate school students born after 1986 who were seronegative for three hepatitis B virus seromarkers at college entrance (n = 1037) were recruited. Four groups of subjects received zero to three doses of a hepatitis B vaccine booster at their free willingness, and their anti-HBs titre were measured at their graduate school entrance. Very low and extremely low antibody titres against the hepatitis B surface antigen were elucidated by graphic inference to determine the required booster dose cut-off value for seropositivity after revaccination.
The anti-HBs seropositive rates in the four groups of subjects receiving the hepatitis B booster vaccine(s) were 17.7%, 52.1%, 78.6% and 90.9% for those receiving zero, one, two and three doses, respectively. In subjects with very low antibody titres against the hepatitis B surface antigen after one dose of the vaccine booster and subjects with an extremely low titre after two doses of the booster, the seropositive rates reached 95% at the cut-off value of 3 mIU/ml.
A seropositive rate of at least 95% can be reached by the administration of two hepatitis B booster doses to youths with extremely low antibody titres against the hepatitis B surface antigen (<3 mIU/ml) and administering one dose to those with very low titres (3-10 mIU/ml) at college.</abstract><cop>England</cop><pmid>31375819</pmid><doi>10.1093/fampra/cmz039</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2893-2187</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Cohort Studies Female Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B Antibodies - immunology Hepatitis B Surface Antigens - immunology Hepatitis B Vaccines - administration & dosage Hepatitis B Vaccines - immunology Humans Immunization, Secondary - methods Male Retrospective Studies Taiwan Young Adult |
| title | Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen |
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