Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients
Host‐microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttrans...
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| Veröffentlicht in: | American journal of transplantation 2020-01, Vol.20 (1), p.145-158 |
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| creator | Colas, Luc Mongodin, Emmanuel F. Montassier, Emmanuel Chesneau, Mélanie Guerif, Pierrick Hittle, Lauren Giral, Magali Bromberg, Jonathan S. Brouard, Sophie Blancho, Gilles Branchereau, Julien Cantarovich, Diego Cesbron, Anne Chapelet, Agnès Dantal, Jacques Delbos, Florent Deltombe, Clément Devis, Anne Figueres, Lucile Garandeau, Claire Gourraud‐Vercel, Caroline Hourmant, Maryvonne Kandell, Christine Karam, Georges Kerleau, Clarisse Meurette, Aurélie Moreau, Anne Renaudin, Karine Ville, Simon Walencik, Alexandre |
| description | Host‐microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age‐matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time.
Comparing taxonomic relative abundance and diversity of urinary microbiota between healthy volunteers and tolerant, stable, and minimally immunosuppressed kidney transplanted recipients, this study identifies and associates a specific Proteobacteria profile in the urine of kidney transplanted recipients with spontaneous tolerance. |
| doi_str_mv | 10.1111/ajt.15549 |
| format | Article |
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Comparing taxonomic relative abundance and diversity of urinary microbiota between healthy volunteers and tolerant, stable, and minimally immunosuppressed kidney transplanted recipients, this study identifies and associates a specific Proteobacteria profile in the urine of kidney transplanted recipients with spontaneous tolerance.</description><identifier>ISSN: 1600-6135</identifier><identifier>ISSN: 1600-6143</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.15549</identifier><identifier>PMID: 31374143</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Adult ; Biodiversity ; Biomarkers - urine ; Calcineurin ; Calcineurin inhibitors ; Case-Control Studies ; clinical research/practice ; Female ; Follow-Up Studies ; Graft Rejection - etiology ; Graft Rejection - pathology ; Graft Rejection - urine ; Graft Survival - immunology ; Humans ; Immune system ; Immune Tolerance - immunology ; Immunological tolerance ; immunosuppression/immune modulation ; Immunosuppressive agents ; Kidney transplantation ; Kidney Transplantation - adverse effects ; kidney transplantation/nephrology ; Kidney transplants ; Male ; Microbiomes ; microbiomics ; Microbiota ; Middle Aged ; Prognosis ; Proteobacteria ; Proteobacteria - classification ; Proteobacteria - genetics ; Rapamycin ; Risk Factors ; RNA, Ribosomal, 16S - genetics ; tolerance ; TOR protein ; translational research/science ; Urine</subject><ispartof>American journal of transplantation, 2020-01, Vol.20 (1), p.145-158</ispartof><rights>2019 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2019 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><rights>2020 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-fe0eb8843989d16035ef96f752335a900d4989d18f6a638cd3b8f197a8d7d5b63</citedby><cites>FETCH-LOGICAL-c3889-fe0eb8843989d16035ef96f752335a900d4989d18f6a638cd3b8f197a8d7d5b63</cites><orcidid>0000-0003-3833-7437 ; 0000-0002-1407-8795 ; 0000-0002-6398-1315 ; 0000-0002-2313-1172 ; 0000-0001-8226-4250 ; 0000-0003-1766-0745 ; 0000-0001-7641-1592</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajt.15549$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.15549$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31374143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colas, Luc</creatorcontrib><creatorcontrib>Mongodin, Emmanuel F.</creatorcontrib><creatorcontrib>Montassier, Emmanuel</creatorcontrib><creatorcontrib>Chesneau, Mélanie</creatorcontrib><creatorcontrib>Guerif, Pierrick</creatorcontrib><creatorcontrib>Hittle, Lauren</creatorcontrib><creatorcontrib>Giral, Magali</creatorcontrib><creatorcontrib>Bromberg, Jonathan S.</creatorcontrib><creatorcontrib>Brouard, Sophie</creatorcontrib><creatorcontrib>Blancho, Gilles</creatorcontrib><creatorcontrib>Branchereau, Julien</creatorcontrib><creatorcontrib>Cantarovich, Diego</creatorcontrib><creatorcontrib>Cesbron, Anne</creatorcontrib><creatorcontrib>Chapelet, Agnès</creatorcontrib><creatorcontrib>Dantal, Jacques</creatorcontrib><creatorcontrib>Delbos, Florent</creatorcontrib><creatorcontrib>Deltombe, Clément</creatorcontrib><creatorcontrib>Devis, Anne</creatorcontrib><creatorcontrib>Figueres, Lucile</creatorcontrib><creatorcontrib>Garandeau, Claire</creatorcontrib><creatorcontrib>Gourraud‐Vercel, Caroline</creatorcontrib><creatorcontrib>Hourmant, Maryvonne</creatorcontrib><creatorcontrib>Kandell, Christine</creatorcontrib><creatorcontrib>Karam, Georges</creatorcontrib><creatorcontrib>Kerleau, Clarisse</creatorcontrib><creatorcontrib>Meurette, Aurélie</creatorcontrib><creatorcontrib>Moreau, Anne</creatorcontrib><creatorcontrib>Renaudin, Karine</creatorcontrib><creatorcontrib>Ville, Simon</creatorcontrib><creatorcontrib>Walencik, Alexandre</creatorcontrib><creatorcontrib>DIVAT Consortium</creatorcontrib><title>Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Host‐microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age‐matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time.
Comparing taxonomic relative abundance and diversity of urinary microbiota between healthy volunteers and tolerant, stable, and minimally immunosuppressed kidney transplanted recipients, this study identifies and associates a specific Proteobacteria profile in the urine of kidney transplanted recipients with spontaneous tolerance.</description><subject>Adult</subject><subject>Biodiversity</subject><subject>Biomarkers - urine</subject><subject>Calcineurin</subject><subject>Calcineurin inhibitors</subject><subject>Case-Control Studies</subject><subject>clinical research/practice</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft Rejection - etiology</subject><subject>Graft Rejection - pathology</subject><subject>Graft Rejection - urine</subject><subject>Graft Survival - immunology</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immune Tolerance - immunology</subject><subject>Immunological tolerance</subject><subject>immunosuppression/immune modulation</subject><subject>Immunosuppressive agents</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>kidney transplantation/nephrology</subject><subject>Kidney transplants</subject><subject>Male</subject><subject>Microbiomes</subject><subject>microbiomics</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Proteobacteria</subject><subject>Proteobacteria - classification</subject><subject>Proteobacteria - genetics</subject><subject>Rapamycin</subject><subject>Risk Factors</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>tolerance</subject><subject>TOR protein</subject><subject>translational research/science</subject><subject>Urine</subject><issn>1600-6135</issn><issn>1600-6143</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtP3DAUha0KBFNgwR9Alti0ixnsOE6cJUJ9gJBgMbO2nPha8pDEwXao5t_3wlAWlfDGr0_n3nMuIeecrTiuK7PNKy5l2XwhC14xtqx4KQ4-zkIek68pbRnjdaGKI3IsuKhLZBZk2Iz-eQZqRkvTBJ13vqOPMWQIrekyRG-o9S8Qk8876kc6Rz-auKOD72JofciGBkdz6CGaMdMnb0fY0YyXNPX4ApZGlJ08jDmdkkNn-gRn7_sJ2fz8sb75vbx_-HV7c32_7IRSzdIBg1apUjSqsWhCSHBN5WpZCCFNw5gt336Uq0wlVGdFqxxvaqNsbWVbiRPyba87xYDuUtaDTx302BCEOemiqJTgGIJA9PI_dBvmOGJ3GqvxWvJGMqS-7yk0nVIEp6foB8xBc6ZfZ6BxBvptBshevCvO7QD2g_wXOgJXe-CP72H3uZK-vlvvJf8CkvKRXQ</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Colas, Luc</creator><creator>Mongodin, Emmanuel F.</creator><creator>Montassier, Emmanuel</creator><creator>Chesneau, Mélanie</creator><creator>Guerif, Pierrick</creator><creator>Hittle, Lauren</creator><creator>Giral, Magali</creator><creator>Bromberg, Jonathan S.</creator><creator>Brouard, Sophie</creator><creator>Blancho, Gilles</creator><creator>Branchereau, Julien</creator><creator>Cantarovich, Diego</creator><creator>Cesbron, Anne</creator><creator>Chapelet, Agnès</creator><creator>Dantal, Jacques</creator><creator>Delbos, Florent</creator><creator>Deltombe, Clément</creator><creator>Devis, Anne</creator><creator>Figueres, Lucile</creator><creator>Garandeau, Claire</creator><creator>Gourraud‐Vercel, Caroline</creator><creator>Hourmant, Maryvonne</creator><creator>Kandell, Christine</creator><creator>Karam, Georges</creator><creator>Kerleau, Clarisse</creator><creator>Meurette, Aurélie</creator><creator>Moreau, Anne</creator><creator>Renaudin, Karine</creator><creator>Ville, Simon</creator><creator>Walencik, Alexandre</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3833-7437</orcidid><orcidid>https://orcid.org/0000-0002-1407-8795</orcidid><orcidid>https://orcid.org/0000-0002-6398-1315</orcidid><orcidid>https://orcid.org/0000-0002-2313-1172</orcidid><orcidid>https://orcid.org/0000-0001-8226-4250</orcidid><orcidid>https://orcid.org/0000-0003-1766-0745</orcidid><orcidid>https://orcid.org/0000-0001-7641-1592</orcidid></search><sort><creationdate>202001</creationdate><title>Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients</title><author>Colas, Luc ; Mongodin, Emmanuel F. ; Montassier, Emmanuel ; Chesneau, Mélanie ; Guerif, Pierrick ; Hittle, Lauren ; Giral, Magali ; Bromberg, Jonathan S. ; Brouard, Sophie ; Blancho, Gilles ; Branchereau, Julien ; Cantarovich, Diego ; Cesbron, Anne ; Chapelet, Agnès ; Dantal, Jacques ; Delbos, Florent ; Deltombe, Clément ; Devis, Anne ; Figueres, Lucile ; Garandeau, Claire ; Gourraud‐Vercel, Caroline ; Hourmant, Maryvonne ; Kandell, Christine ; Karam, Georges ; Kerleau, Clarisse ; Meurette, Aurélie ; Moreau, Anne ; Renaudin, Karine ; Ville, Simon ; Walencik, Alexandre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-fe0eb8843989d16035ef96f752335a900d4989d18f6a638cd3b8f197a8d7d5b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Biodiversity</topic><topic>Biomarkers - 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| fulltext | fulltext |
| identifier | ISSN: 1600-6135 |
| ispartof | American journal of transplantation, 2020-01, Vol.20 (1), p.145-158 |
| issn | 1600-6135 1600-6143 1600-6143 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2268311373 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Biodiversity Biomarkers - urine Calcineurin Calcineurin inhibitors Case-Control Studies clinical research/practice Female Follow-Up Studies Graft Rejection - etiology Graft Rejection - pathology Graft Rejection - urine Graft Survival - immunology Humans Immune system Immune Tolerance - immunology Immunological tolerance immunosuppression/immune modulation Immunosuppressive agents Kidney transplantation Kidney Transplantation - adverse effects kidney transplantation/nephrology Kidney transplants Male Microbiomes microbiomics Microbiota Middle Aged Prognosis Proteobacteria Proteobacteria - classification Proteobacteria - genetics Rapamycin Risk Factors RNA, Ribosomal, 16S - genetics tolerance TOR protein translational research/science Urine |
| title | Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T19%3A51%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Unique%20and%20specific%20Proteobacteria%20diversity%20in%20urinary%20microbiota%20of%20tolerant%20kidney%20transplanted%20recipients&rft.jtitle=American%20journal%20of%20transplantation&rft.au=Colas,%20Luc&rft.aucorp=DIVAT%20Consortium&rft.date=2020-01&rft.volume=20&rft.issue=1&rft.spage=145&rft.epage=158&rft.pages=145-158&rft.issn=1600-6135&rft.eissn=1600-6143&rft_id=info:doi/10.1111/ajt.15549&rft_dat=%3Cproquest_cross%3E2331751950%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2331751950&rft_id=info:pmid/31374143&rfr_iscdi=true |