Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes

Human liver cancers, including hepatocellular carcinomas and intra-hepatic cholangiocarcinomas, are often diagnosed late with poor prognosis. A better understanding of cancer initiation could provide potential preventive therapies and increase survival. Models for studying human liver cancer initiat...

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Veröffentlicht in:	Nature cell biology 2019-08, Vol.21 (8), p.1015-1026
Hauptverfasser:	Sun, Lulu, Wang, Yuqing, Cen, Jin, Ma, Xiaolong, Cui, Lei, Qiu, Zhixin, Zhang, Zhengtao, Li, Hong, Yang, Run-Zhou, Wang, Chenhua, Chen, Xiaotao, Wang, Le, Ye, Yao, Zhang, Haibin, Pan, Guoyu, Kang, Jian-Sheng, Ji, Yuan, Zheng, Yun-Wen, Zheng, Shan, Hui, Lijian
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/31 14 14/19 14/34 38 38/1 38/39 38/77 42 42/109 631/1647/767/70 631/532/2435 631/67 64 64/60 Biomedical and Life Sciences c-Myc protein Cancer Research Carcinogenesis Cell Biology Cholangiocarcinoma Deactivation Development and progression Developmental Biology Endoplasmic reticulum Genetic engineering Hepatocellular carcinoma Hepatocytes Inactivation Life Sciences Liver Liver cancer Medical prognosis Mutation Myc protein Organoids p53 Protein Stem Cells Tissue culture Tissue engineering
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