Medication‐related osteonecrosis of the jaw‐like lesions in rodents: A comprehensive systematic review and meta‐analysis
Objective The aim of this comprehensive systematic review and meta‐analysis was to investigate the pathology and pathogenesis of medication‐related osteonecrosis of the jaw (MRONJ) in rodents. Background Medication‐related osteonecrosis of the jaw occurs in patients taking antiresorptive drugs, such...
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| Veröffentlicht in: | Gerodontology 2019-12, Vol.36 (4), p.313-324 |
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| creator | Kuroshima, Shinichiro Sasaki, Muneteru Murata, Hiroshi Sawase, Takashi |
| description | Objective
The aim of this comprehensive systematic review and meta‐analysis was to investigate the pathology and pathogenesis of medication‐related osteonecrosis of the jaw (MRONJ) in rodents.
Background
Medication‐related osteonecrosis of the jaw occurs in patients taking antiresorptive drugs, such as bisphosphonates and denosumab, and anti‐angiogenesis agents. However, there is limited information about the pathology of MRONJ at the clinical level. Moreover, no information about the exact mechanisms of MRONJ is clinically available.
Materials and methods
The PubMed, SCOPUS and Medline databases were used to search for relevant articles up to April 2018 by two independent reviewers. A systematic review and meta‐analysis were performed.
Results
Of the 1841 studies, 10 articles met the eligibility criteria. The most commonly observed pathology of MRONJ‐like lesions was exposed bone without epithelial coverage, decreases in the number of osteocytes and increases in necrotic bone with more empty lacunae. No definitive pathogenesis of MRONJ‐like lesions was found. Both zoledronic acid (ZA) monotherapy and ZA/chemotherapeutic and/or dexamethasone combination therapy were significant high‐risk factors for developing MRONJ‐like lesions (P |
| doi_str_mv | 10.1111/ger.12416 |
| format | Article |
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The aim of this comprehensive systematic review and meta‐analysis was to investigate the pathology and pathogenesis of medication‐related osteonecrosis of the jaw (MRONJ) in rodents.
Background
Medication‐related osteonecrosis of the jaw occurs in patients taking antiresorptive drugs, such as bisphosphonates and denosumab, and anti‐angiogenesis agents. However, there is limited information about the pathology of MRONJ at the clinical level. Moreover, no information about the exact mechanisms of MRONJ is clinically available.
Materials and methods
The PubMed, SCOPUS and Medline databases were used to search for relevant articles up to April 2018 by two independent reviewers. A systematic review and meta‐analysis were performed.
Results
Of the 1841 studies, 10 articles met the eligibility criteria. The most commonly observed pathology of MRONJ‐like lesions was exposed bone without epithelial coverage, decreases in the number of osteocytes and increases in necrotic bone with more empty lacunae. No definitive pathogenesis of MRONJ‐like lesions was found. Both zoledronic acid (ZA) monotherapy and ZA/chemotherapeutic and/or dexamethasone combination therapy were significant high‐risk factors for developing MRONJ‐like lesions (P < 0.00001 and P < 0.0001, respectively).
Conclusion
Based on rodent studies, common pathological findings were extracted in bisphosphonate‐related ONJ (BRONJ)‐like lesions, whereas no definitive pathogenesis was identified. There is no information about the pathology and pathogenesis of denosumab‐related ONJ. These findings clearly suggest that accumulation of scientific evidence based on animal studies is absolutely necessary to explore the pathology and pathogenesis of MRONJ in humans. ZA administration would be a significant risk factor for developing BRONJ‐like lesions.</description><identifier>ISSN: 0734-0664</identifier><identifier>EISSN: 1741-2358</identifier><identifier>DOI: 10.1111/ger.12416</identifier><identifier>PMID: 31373407</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Bisphosphonate-Associated Osteonecrosis of the Jaw ; Bone Density Conservation Agents ; Denosumab ; Dentistry ; Diphosphonates ; Humans ; osteonecrosis of the jaw ; RANKL/RANK ; Rodentia ; Tooth Extraction ; zoledronic acid</subject><ispartof>Gerodontology, 2019-12, Vol.36 (4), p.313-324</ispartof><rights>2019 Gerodontology Association and John Wiley & Sons Ltd</rights><rights>2019 Gerodontology Association and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3916-dd2286cfd9e3d59b99f0684af44efdcc2d5945633fb52bc128ac6f887ce892153</citedby><cites>FETCH-LOGICAL-c3916-dd2286cfd9e3d59b99f0684af44efdcc2d5945633fb52bc128ac6f887ce892153</cites><orcidid>0000-0001-9891-9987</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fger.12416$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fger.12416$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31373407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuroshima, Shinichiro</creatorcontrib><creatorcontrib>Sasaki, Muneteru</creatorcontrib><creatorcontrib>Murata, Hiroshi</creatorcontrib><creatorcontrib>Sawase, Takashi</creatorcontrib><title>Medication‐related osteonecrosis of the jaw‐like lesions in rodents: A comprehensive systematic review and meta‐analysis</title><title>Gerodontology</title><addtitle>Gerodontology</addtitle><description>Objective
The aim of this comprehensive systematic review and meta‐analysis was to investigate the pathology and pathogenesis of medication‐related osteonecrosis of the jaw (MRONJ) in rodents.
Background
Medication‐related osteonecrosis of the jaw occurs in patients taking antiresorptive drugs, such as bisphosphonates and denosumab, and anti‐angiogenesis agents. However, there is limited information about the pathology of MRONJ at the clinical level. Moreover, no information about the exact mechanisms of MRONJ is clinically available.
Materials and methods
The PubMed, SCOPUS and Medline databases were used to search for relevant articles up to April 2018 by two independent reviewers. A systematic review and meta‐analysis were performed.
Results
Of the 1841 studies, 10 articles met the eligibility criteria. The most commonly observed pathology of MRONJ‐like lesions was exposed bone without epithelial coverage, decreases in the number of osteocytes and increases in necrotic bone with more empty lacunae. No definitive pathogenesis of MRONJ‐like lesions was found. Both zoledronic acid (ZA) monotherapy and ZA/chemotherapeutic and/or dexamethasone combination therapy were significant high‐risk factors for developing MRONJ‐like lesions (P < 0.00001 and P < 0.0001, respectively).
Conclusion
Based on rodent studies, common pathological findings were extracted in bisphosphonate‐related ONJ (BRONJ)‐like lesions, whereas no definitive pathogenesis was identified. There is no information about the pathology and pathogenesis of denosumab‐related ONJ. These findings clearly suggest that accumulation of scientific evidence based on animal studies is absolutely necessary to explore the pathology and pathogenesis of MRONJ in humans. ZA administration would be a significant risk factor for developing BRONJ‐like lesions.</description><subject>Animals</subject><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw</subject><subject>Bone Density Conservation Agents</subject><subject>Denosumab</subject><subject>Dentistry</subject><subject>Diphosphonates</subject><subject>Humans</subject><subject>osteonecrosis of the jaw</subject><subject>RANKL/RANK</subject><subject>Rodentia</subject><subject>Tooth Extraction</subject><subject>zoledronic acid</subject><issn>0734-0664</issn><issn>1741-2358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLFOwzAQhi0EglIYeAHkEYaU2E6chA2hUpCKkBDMkWOfqSGJi51SdUE8As_Ik-CSwsYtJ91990n3I3RE4hEJdfYEbkRoQvgWGpAsIRFlab6NBnHGkijmPNlD-94_xzFNM8p20R4jLKzibIDeb0EZKTpj26-PTwe16EBh6zuwLUhnvfHYatzNAD-LZUBq8wK4Bh8OPDYtdlZB2_lzfIGlbeYOZtB68wbYr4KkCWaJHbwZWGLRKtxAJ4JFtKJeBfcB2tGi9nC46UP0eDV-uLyOpneTm8uLaSRZQXikFKU5l1oVwFRaVEWhY54nQicJaCUlDcMk5YzpKqWVJDQXkus8zyTkBSUpG6KT3jt39nUBvisb4yXUtWjBLnxJKc8ZIZSTgJ726Pp770CXc2ca4VYlict13GWIu_yJO7DHG-2iakD9kb_5BuCsB5amhtX_pnIyvu-V3158jyc</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Kuroshima, Shinichiro</creator><creator>Sasaki, Muneteru</creator><creator>Murata, Hiroshi</creator><creator>Sawase, Takashi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9891-9987</orcidid></search><sort><creationdate>201912</creationdate><title>Medication‐related osteonecrosis of the jaw‐like lesions in rodents: A comprehensive systematic review and meta‐analysis</title><author>Kuroshima, Shinichiro ; Sasaki, Muneteru ; Murata, Hiroshi ; Sawase, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3916-dd2286cfd9e3d59b99f0684af44efdcc2d5945633fb52bc128ac6f887ce892153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Bisphosphonate-Associated Osteonecrosis of the Jaw</topic><topic>Bone Density Conservation Agents</topic><topic>Denosumab</topic><topic>Dentistry</topic><topic>Diphosphonates</topic><topic>Humans</topic><topic>osteonecrosis of the jaw</topic><topic>RANKL/RANK</topic><topic>Rodentia</topic><topic>Tooth Extraction</topic><topic>zoledronic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuroshima, Shinichiro</creatorcontrib><creatorcontrib>Sasaki, Muneteru</creatorcontrib><creatorcontrib>Murata, Hiroshi</creatorcontrib><creatorcontrib>Sawase, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gerodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuroshima, Shinichiro</au><au>Sasaki, Muneteru</au><au>Murata, Hiroshi</au><au>Sawase, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medication‐related osteonecrosis of the jaw‐like lesions in rodents: A comprehensive systematic review and meta‐analysis</atitle><jtitle>Gerodontology</jtitle><addtitle>Gerodontology</addtitle><date>2019-12</date><risdate>2019</risdate><volume>36</volume><issue>4</issue><spage>313</spage><epage>324</epage><pages>313-324</pages><issn>0734-0664</issn><eissn>1741-2358</eissn><abstract>Objective
The aim of this comprehensive systematic review and meta‐analysis was to investigate the pathology and pathogenesis of medication‐related osteonecrosis of the jaw (MRONJ) in rodents.
Background
Medication‐related osteonecrosis of the jaw occurs in patients taking antiresorptive drugs, such as bisphosphonates and denosumab, and anti‐angiogenesis agents. However, there is limited information about the pathology of MRONJ at the clinical level. Moreover, no information about the exact mechanisms of MRONJ is clinically available.
Materials and methods
The PubMed, SCOPUS and Medline databases were used to search for relevant articles up to April 2018 by two independent reviewers. A systematic review and meta‐analysis were performed.
Results
Of the 1841 studies, 10 articles met the eligibility criteria. The most commonly observed pathology of MRONJ‐like lesions was exposed bone without epithelial coverage, decreases in the number of osteocytes and increases in necrotic bone with more empty lacunae. No definitive pathogenesis of MRONJ‐like lesions was found. Both zoledronic acid (ZA) monotherapy and ZA/chemotherapeutic and/or dexamethasone combination therapy were significant high‐risk factors for developing MRONJ‐like lesions (P < 0.00001 and P < 0.0001, respectively).
Conclusion
Based on rodent studies, common pathological findings were extracted in bisphosphonate‐related ONJ (BRONJ)‐like lesions, whereas no definitive pathogenesis was identified. There is no information about the pathology and pathogenesis of denosumab‐related ONJ. These findings clearly suggest that accumulation of scientific evidence based on animal studies is absolutely necessary to explore the pathology and pathogenesis of MRONJ in humans. ZA administration would be a significant risk factor for developing BRONJ‐like lesions.</abstract><cop>England</cop><pmid>31373407</pmid><doi>10.1111/ger.12416</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9891-9987</orcidid></addata></record> |
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| subjects | Animals Bisphosphonate-Associated Osteonecrosis of the Jaw Bone Density Conservation Agents Denosumab Dentistry Diphosphonates Humans osteonecrosis of the jaw RANKL/RANK Rodentia Tooth Extraction zoledronic acid |
| title | Medication‐related osteonecrosis of the jaw‐like lesions in rodents: A comprehensive systematic review and meta‐analysis |
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