Evaluation of resazurin-based rapid test to detect colistin resistance in Acinetobacter baumannii isolates
Acinetobacter baumannii primarily causes colonization, yet it can be an opportunistic pathogen associated with hospital-acquired infections. Many countries report rapid spread of carbapenem-resistant Acinetobacter baumannii (CRAb) which limits treatment options, with colistin frequently being the la...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2019-11, Vol.38 (11), p.2159-2162 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Germ, Julija Poirel, Laurent Kisek, Tjasa Cerar Spik, Vesna Cvitkovic Seme, Katja Premru, Manica Mueller Zupanc, Tatjana Lejko Nordmann, Patrice Pirs, Mateja |
| description | Acinetobacter baumannii
primarily causes colonization, yet it can be an opportunistic pathogen associated with hospital-acquired infections. Many countries report rapid spread of carbapenem-resistant
Acinetobacter baumannii
(CRAb) which limits treatment options, with colistin frequently being the last line treatment option. The aim of our study was to evaluate a recently developed rapid method, namely the Rapid ResaPolymyxin test, for detection of colistin resistance (ColR) in
Acinetobacter baumannii
. This test was used for rapid screening of colistin resistance in a clinical setting where there is endemicity of CRAb isolates. A total of 82
A. baumannii
clinical isolates were included in the evaluation. The majority of them were resistant to carbapenems (75/82, 91.5%). A total of 37 isolates (45.1%) were resistant to colistin, all being resistant to carbapenems. None of the ColR isolates carried the plasmid-mediated
mcr-1
to
-5
genes. The Rapid ResaPolymyxin NP test reached a 95.1% categorical agreement with results of reference broth microdilution method, with 93.3% sensitivity and specificity, and positive and negative predictive values being respectively at 92.3% and 97.7%. The Rapid ResaPolymyxin NP test performed well on our collection of clinical and surveillance CRAb isolates from the Central Slovenia region. The test is inexpensive and easy to integrate into laboratory workflow. The main value of the test is rapid categorization of susceptibility and resistance which has important implications with respect to the treatment strategy as well as the infection control measures. |
| doi_str_mv | 10.1007/s10096-019-03657-1 |
| format | Article |
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primarily causes colonization, yet it can be an opportunistic pathogen associated with hospital-acquired infections. Many countries report rapid spread of carbapenem-resistant
Acinetobacter baumannii
(CRAb) which limits treatment options, with colistin frequently being the last line treatment option. The aim of our study was to evaluate a recently developed rapid method, namely the Rapid ResaPolymyxin test, for detection of colistin resistance (ColR) in
Acinetobacter baumannii
. This test was used for rapid screening of colistin resistance in a clinical setting where there is endemicity of CRAb isolates. A total of 82
A. baumannii
clinical isolates were included in the evaluation. The majority of them were resistant to carbapenems (75/82, 91.5%). A total of 37 isolates (45.1%) were resistant to colistin, all being resistant to carbapenems. None of the ColR isolates carried the plasmid-mediated
mcr-1
to
-5
genes. The Rapid ResaPolymyxin NP test reached a 95.1% categorical agreement with results of reference broth microdilution method, with 93.3% sensitivity and specificity, and positive and negative predictive values being respectively at 92.3% and 97.7%. The Rapid ResaPolymyxin NP test performed well on our collection of clinical and surveillance CRAb isolates from the Central Slovenia region. The test is inexpensive and easy to integrate into laboratory workflow. The main value of the test is rapid categorization of susceptibility and resistance which has important implications with respect to the treatment strategy as well as the infection control measures.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-019-03657-1</identifier><identifier>PMID: 31372908</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acinetobacter baumannii ; Acinetobacter baumannii - drug effects ; Acinetobacter baumannii - genetics ; Acinetobacter baumannii - isolation & purification ; Acinetobacter Infections - microbiology ; Anti-Bacterial Agents - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Carbapenems ; Carbapenems - pharmacology ; Clinical isolates ; Colistin ; Colistin - pharmacology ; Colonization ; Diagnostic Tests, Routine ; Drug Resistance, Bacterial - genetics ; Genes, Bacterial - genetics ; Humans ; Indicators and Reagents ; Internal Medicine ; Medical Microbiology ; Microbial Sensitivity Tests - methods ; Microbial Sensitivity Tests - standards ; Opportunist infection ; Original Article ; Oxazines ; Reagent Kits, Diagnostic ; Sensitivity and Specificity ; Workflow ; Xanthenes</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2019-11, Vol.38 (11), p.2159-2162</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Clinical Microbiology & Infectious Diseases is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-d7206ffff993c637edf845b1fc9498ce3855ac2c823fed704a6db3eb8f4a28383</citedby><cites>FETCH-LOGICAL-c375t-d7206ffff993c637edf845b1fc9498ce3855ac2c823fed704a6db3eb8f4a28383</cites><orcidid>0000-0003-3467-5412</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-019-03657-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-019-03657-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31372908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Germ, Julija</creatorcontrib><creatorcontrib>Poirel, Laurent</creatorcontrib><creatorcontrib>Kisek, Tjasa Cerar</creatorcontrib><creatorcontrib>Spik, Vesna Cvitkovic</creatorcontrib><creatorcontrib>Seme, Katja</creatorcontrib><creatorcontrib>Premru, Manica Mueller</creatorcontrib><creatorcontrib>Zupanc, Tatjana Lejko</creatorcontrib><creatorcontrib>Nordmann, Patrice</creatorcontrib><creatorcontrib>Pirs, Mateja</creatorcontrib><title>Evaluation of resazurin-based rapid test to detect colistin resistance in Acinetobacter baumannii isolates</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Acinetobacter baumannii
primarily causes colonization, yet it can be an opportunistic pathogen associated with hospital-acquired infections. Many countries report rapid spread of carbapenem-resistant
Acinetobacter baumannii
(CRAb) which limits treatment options, with colistin frequently being the last line treatment option. The aim of our study was to evaluate a recently developed rapid method, namely the Rapid ResaPolymyxin test, for detection of colistin resistance (ColR) in
Acinetobacter baumannii
. This test was used for rapid screening of colistin resistance in a clinical setting where there is endemicity of CRAb isolates. A total of 82
A. baumannii
clinical isolates were included in the evaluation. The majority of them were resistant to carbapenems (75/82, 91.5%). A total of 37 isolates (45.1%) were resistant to colistin, all being resistant to carbapenems. None of the ColR isolates carried the plasmid-mediated
mcr-1
to
-5
genes. The Rapid ResaPolymyxin NP test reached a 95.1% categorical agreement with results of reference broth microdilution method, with 93.3% sensitivity and specificity, and positive and negative predictive values being respectively at 92.3% and 97.7%. The Rapid ResaPolymyxin NP test performed well on our collection of clinical and surveillance CRAb isolates from the Central Slovenia region. The test is inexpensive and easy to integrate into laboratory workflow. The main value of the test is rapid categorization of susceptibility and resistance which has important implications with respect to the treatment strategy as well as the infection control measures.</description><subject>Acinetobacter baumannii</subject><subject>Acinetobacter baumannii - drug effects</subject><subject>Acinetobacter baumannii - genetics</subject><subject>Acinetobacter baumannii - isolation & purification</subject><subject>Acinetobacter Infections - microbiology</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carbapenems</subject><subject>Carbapenems - pharmacology</subject><subject>Clinical isolates</subject><subject>Colistin</subject><subject>Colistin - pharmacology</subject><subject>Colonization</subject><subject>Diagnostic Tests, Routine</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Genes, Bacterial - genetics</subject><subject>Humans</subject><subject>Indicators and Reagents</subject><subject>Internal Medicine</subject><subject>Medical Microbiology</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Microbial Sensitivity Tests - standards</subject><subject>Opportunist infection</subject><subject>Original Article</subject><subject>Oxazines</subject><subject>Reagent Kits, Diagnostic</subject><subject>Sensitivity and Specificity</subject><subject>Workflow</subject><subject>Xanthenes</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9rHSEUxSW0JK9pv0AXQeimG1v1zoy6DCH9A4Fs0rU4zp3iY56-qBNIP319fUkDXdTF1Yu_c7x4CHkv-CfBufpcWjUD48IwDkOvmDghG9FBzzpQ8IpsuIGOGSXhjLwpZcubSCt1Ss5AgJKG6w3ZXj-4ZXU1pEjTTDMW92vNIbLRFZxodvsw0Yql0prohBV9pT4todQQD3Q7uOiRtu7Sh4g1jc5XzHR0687FGAINJS2uWbwlr2e3FHz3tJ-TH1-u766-sZvbr9-vLm-YB9VXNinJh7ktY8APoHCaddePYvamM9oj6L53XnotYcZJ8c4N0wg46rlzUoOGc_Lx6LvP6X5to9tdKB6XxUVMa7FSDhoE17xv6Id_0G1ac2zTHSjVKyMMNEoeKZ9TKRlnu89h5_KjFdwekrDHJGxLwv5JwoomuniyXscdTn8lz1_fADgCpV3Fn5hf3v6P7W9KNZV4</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Germ, Julija</creator><creator>Poirel, Laurent</creator><creator>Kisek, Tjasa Cerar</creator><creator>Spik, Vesna Cvitkovic</creator><creator>Seme, Katja</creator><creator>Premru, Manica Mueller</creator><creator>Zupanc, Tatjana Lejko</creator><creator>Nordmann, Patrice</creator><creator>Pirs, Mateja</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3467-5412</orcidid></search><sort><creationdate>20191101</creationdate><title>Evaluation of resazurin-based rapid test to detect colistin resistance in Acinetobacter baumannii isolates</title><author>Germ, Julija ; Poirel, Laurent ; Kisek, Tjasa Cerar ; Spik, Vesna Cvitkovic ; Seme, Katja ; Premru, Manica Mueller ; Zupanc, Tatjana Lejko ; Nordmann, Patrice ; Pirs, Mateja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-d7206ffff993c637edf845b1fc9498ce3855ac2c823fed704a6db3eb8f4a28383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acinetobacter baumannii</topic><topic>Acinetobacter baumannii - 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Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Germ, Julija</au><au>Poirel, Laurent</au><au>Kisek, Tjasa Cerar</au><au>Spik, Vesna Cvitkovic</au><au>Seme, Katja</au><au>Premru, Manica Mueller</au><au>Zupanc, Tatjana Lejko</au><au>Nordmann, Patrice</au><au>Pirs, Mateja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of resazurin-based rapid test to detect colistin resistance in Acinetobacter baumannii isolates</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>38</volume><issue>11</issue><spage>2159</spage><epage>2162</epage><pages>2159-2162</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Acinetobacter baumannii
primarily causes colonization, yet it can be an opportunistic pathogen associated with hospital-acquired infections. Many countries report rapid spread of carbapenem-resistant
Acinetobacter baumannii
(CRAb) which limits treatment options, with colistin frequently being the last line treatment option. The aim of our study was to evaluate a recently developed rapid method, namely the Rapid ResaPolymyxin test, for detection of colistin resistance (ColR) in
Acinetobacter baumannii
. This test was used for rapid screening of colistin resistance in a clinical setting where there is endemicity of CRAb isolates. A total of 82
A. baumannii
clinical isolates were included in the evaluation. The majority of them were resistant to carbapenems (75/82, 91.5%). A total of 37 isolates (45.1%) were resistant to colistin, all being resistant to carbapenems. None of the ColR isolates carried the plasmid-mediated
mcr-1
to
-5
genes. The Rapid ResaPolymyxin NP test reached a 95.1% categorical agreement with results of reference broth microdilution method, with 93.3% sensitivity and specificity, and positive and negative predictive values being respectively at 92.3% and 97.7%. The Rapid ResaPolymyxin NP test performed well on our collection of clinical and surveillance CRAb isolates from the Central Slovenia region. The test is inexpensive and easy to integrate into laboratory workflow. The main value of the test is rapid categorization of susceptibility and resistance which has important implications with respect to the treatment strategy as well as the infection control measures.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31372908</pmid><doi>10.1007/s10096-019-03657-1</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-3467-5412</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2019-11, Vol.38 (11), p.2159-2162 |
| issn | 0934-9723 1435-4373 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Acinetobacter baumannii Acinetobacter baumannii - drug effects Acinetobacter baumannii - genetics Acinetobacter baumannii - isolation & purification Acinetobacter Infections - microbiology Anti-Bacterial Agents - pharmacology Biomedical and Life Sciences Biomedicine Carbapenems Carbapenems - pharmacology Clinical isolates Colistin Colistin - pharmacology Colonization Diagnostic Tests, Routine Drug Resistance, Bacterial - genetics Genes, Bacterial - genetics Humans Indicators and Reagents Internal Medicine Medical Microbiology Microbial Sensitivity Tests - methods Microbial Sensitivity Tests - standards Opportunist infection Original Article Oxazines Reagent Kits, Diagnostic Sensitivity and Specificity Workflow Xanthenes |
| title | Evaluation of resazurin-based rapid test to detect colistin resistance in Acinetobacter baumannii isolates |
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