Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

Emerging resistance to current antimalarial medicines underscores the importance of identifying new drug targets and novel compounds. Malaria parasites are purine auxotrophic and import purines via the Plasmodium falciparum equilibrative nucleoside transporter type 1 (PfENT1). We previously showed t...

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Veröffentlicht in:	ACS infectious diseases 2019-10, Vol.5 (10), p.1738-1753
Hauptverfasser:	Sosa, Yvett, Deniskin, Roman, Frame, I. J, Steiginga, Matthew S, Bandyopadhyay, Deepak, Graybill, Todd L, Kallal, Lorena A, Ouellette, Michael T, Pope, Andrew J, Widdowson, Katherine L, Young, Robert J, Akabas, Myles H
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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