Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages

Long-chain acyl-coenzyme A synthetases (ACSLs) are a family of enzymes that convert free long-chain fatty acids into their acyl-coenzyme A (CoA) forms. ACSL4, belonging to the ACSL family, shows a preferential use of arachidonic acid (AA) as its substrate and plays a role in the remodeling of AA-con...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2019-11, Vol.1864 (11), p.1606-1618
Hauptverfasser:	Kuwata, Hiroshi, Nakatani, Eriko, Shimbara-Matsubayashi, Satoko, Ishikawa, Fumihiro, Shibanuma, Motoko, Sasaki, Yuka, Yoda, Emiko, Nakatani, Yoshihito, Hara, Shuntaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Animals Arachidonic Acid - metabolism Cells, Cultured Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Eicosanoid Fatty Acids, Unsaturated - metabolism Female Glycerophospholipid Long-chain acyl-CoA synthetase 4 Macrophages - metabolism Mice Mice, Knockout Phagocytosis Phospholipids - metabolism Polyunsaturated fatty acid Substrate Specificity
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