Peptides ToAP3 and ToAP4 decrease release of inflammatory cytokines through TLR-4 blocking

Antimicrobial peptides (AMPs) are small molecules with microbicidal and immunoregulatory activities. In this study we evaluated the anti-inflammatory and antimicrobial activities of peptides ToAP3 and ToAP4, AMPs from the venom of the Brazilian scorpion Tityus obscurus. To test the peptides’ activit...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-10, Vol.118, p.109152-109152, Article 109152
Hauptverfasser:	Veloso Júnior, Paulo Henrique de Holanda, Simon, Karina Smidt, de Castro, Raffael Júnio Araújo, Coelho, Luísa Coutinho, Erazo, Fabián Andres Hurtado, de Souza, Adolfo Carlos Barros, das Neves, Rogério Coutinho, Lozano, Viviane Furlan, Schwartz, Elizabeth Ferroni, Tavares, Aldo Henrique, Mortari, Márcia Renata, Junqueira-Kipnis, Ana Paula, Silva-Pereira, Ildinete, Bocca, Anamelia Lorenzetti
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cell Line Cryptococcus neoformans - drug effects Cytokines - metabolism Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Immunity, Innate - drug effects Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Mice, Inbred C57BL Mice, Knockout Microbial Sensitivity Tests Mycobacterium abscessus - drug effects Peptides - isolation & purification Peptides - pharmacology Scorpion venom Scorpion Venoms - chemistry Scorpions Tityus Obscurus ToAP3 ToaP4 Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics
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