Estrogen regulates forkhead transcription factor 2 to promote apoptosis of human ovarian granulosa-like tumor cells

•FOXL2 is highly expressed in KGN cells and GCT tissues.•FOXL2 inhibits E2 synthesis, while E2 up-regulated the FOXL2 expression in KGN•cells.•Estrogen induces FOXL2 phosphorylation via GPCR-PKC non-genomic pathway.•Estrogen promotes cell apoptosis via FOXL2. Granulosa cell tumors of the ovary (GCTs...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2019-11, Vol.194, p.105418-105418, Article 105418
Hauptverfasser:	Wu, Jun, Miao, Chunlei, Lv, Xiaoyu, Zhang, Yujie, Li, Yanyan, Wang, Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis Apoptosis - drug effects Cell adhesion & migration Cell growth Cell Line Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Clonal deletion Estradiol - pharmacology Estrogen Estrogens Estrogens - pharmacology Female Forkhead Box Protein L2 - genetics Forkhead Box Protein L2 - metabolism Forkhead protein FOXL2 GCTs GPR30 Granulosa Cell Tumor - metabolism Humans Kinases Middle Aged Ovarian cancer Ovarian Neoplasms - metabolism Point mutation Protein kinase C Proteins RNA, Messenger - metabolism Signal transduction Transcription factors Tumor cells Tumors Young Adult
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