A B cell–dependent pathway drives chronic lung allograft rejection after ischemia–reperfusion injury in mice

Chronic lung allograft dysfunction (CLAD) limits long‐term survival after lung transplant (LT). Ischemia–reperfusion injury (IRI) promotes chronic rejection (CR) and CLAD, but the underlying mechanisms are not well understood. To examine mechanisms linking IRI to CR, a mouse orthotopic LT model usin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of transplantation 2019-12, Vol.19 (12), p.3377-3389
Hauptverfasser:	Watanabe, Tatsuaki, Martinu, Tereza, Chruscinski, Andrzej, Boonstra, Kristen, Joe, Betty, Horie, Miho, Guan, Zehong, Bei, Ke Fan, Hwang, David M., Liu, Mingyao, Keshavjee, Shaf, Juvet, Stephen C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts animal models: murine Animals Autoantibodies Autoantibodies - immunology B cell biology B-Lymphocytes - immunology basic (laboratory) research/science bronchiolitis obliterans (BOS) Chronic Disease Disease Models, Animal Fibrosis Fibrosis - etiology Fibrosis - pathology Graft rejection Graft Rejection - etiology Graft Rejection - pathology Graft Survival - immunology immunobiology immunosuppression/immune modulation innate immunity Ischemia lung (allograft) function/dysfunction Lung transplantation Lung Transplantation - adverse effects lung transplantation/pulmonology Lung transplants Lymphocytes T Male Mice Preservation Reperfusion Reperfusion Injury - complications Reperfusion Injury - pathology Skin & tissue grafts Syngeneic grafts Transplants & implants Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!