Calhex231 Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro

Diabetic cardiomyopathy (DCM) is a major complication of diabetes, and features myocardial fibrosis as its main pathological feature. Calcium sensing receptor (CaSR) is a G protein-coupled receptor, which involves in myocardial fibrosis by regulation of calcium homeostasis. Calhex231, the CaSR inhib...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2019/08/01, Vol.42(8), pp.1337-1344
Hauptverfasser:	Yuan, Hui, Xu, Jiyu, Xu, Xiaoyi, Gao, Tielei, Wang, Yuehong, Fan, Yuqi, Hu, Jing, Shao, Yiying, Zhao, Bingbing, Li, Hongzhu, Sun, Jian, Xu, Changqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Calcium Calcium (intracellular) Calcium homeostasis Calcium ions calcium sensitive receptor Calcium-sensing receptors Calhex231 Cardiomyopathy Chemical compounds Collagen Collagen (type I) Contractility Diabetes Diabetes mellitus diabetic cardiomyopathy Fibroblasts Fibrosis Gelatinase A Gelatinase B Glucose Heart Homeostasis itch Matrix metalloproteinase Metalloproteinase Muscle contraction Muscles myocardial fibrosis Neonates Proteasomes Smad2 protein Smad3 protein Smad7 protein Smooth muscle Transforming growth factor-b1 transforming growth factor-β1 (TGF-β1) Ubiquitin Ubiquitination
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