Therapeutic effects of resveratrol in Escherichia coli-induced rat endometritis model
Endometritis is an inflammatory disorder of the endometrial lining of the uterine tissue in postpartum stage. Endometritis mostly progresses subclinically and causes infertility through the disruption of the hormonal balance. It has been shown in many studies that resveratrol has anti-inflammatory a...
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| creator | Demirel, Murside Ayse Han, Sevtap Tokmak, Aytekin Ercan Gokay, Nilufer Uludag, Mecit Orhan Yildirir Ustun, Tugçe Cicek, Ali Fuat |
| description | Endometritis is an inflammatory disorder of the endometrial lining of the uterine tissue in postpartum stage. Endometritis mostly progresses subclinically and causes infertility through the disruption of the hormonal balance. It has been shown in many studies that resveratrol has anti-inflammatory and antioxidant properties. However, the possible beneficial effects of resveratrol in endometritis have not been determined yet. The aim of the present study is to evaluate the treatment potential of resveratrol in an experimentally induced endometritis model in rats. Endometritis was induced in 12-week-old female, nonpregnant, Sprague Dawley rats. The animals were divided into six groups: control (NaCl 0.9%) and endometritis (NaCl 0.9%), marbofloxacin + PGF
2α
, marbofloxacin, marbofloxacin + resveratrol, and resveratrol groups. To induce endometritis, 5 mg/kg/s.c. progesterone was given for 5 days, and then
Escherichia coli
(50 μl, 1 × 10
5
cfu/rat) was injected in the right cornu uteri following laparotomy. Sixteen hours after bacterial inoculation, the treatment protocol was applied for 14 days. At the end of the experiment, the total oxidant status (TOS) and total antioxidant status (TAS) were examined spectrophotometrically in uterus tissues. The severity of inflammation in uterus samples and follicular activity in ovarian tissues were histopathologically evaluated. In addition, serum cytokine levels were determined. While TAS in uterine tissue significantly increased in the resveratrol group when compared to that of the other groups (
p
0.05). The inflammation of the endometrium and the numbers of corpus luteum in the endometritis group were highly significant when compared to those of the other groups (
p
|
| doi_str_mv | 10.1007/s00210-019-01696-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2267747233</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2267747233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-51781a1d3cb746aa5f6a776203f3458f91fff1604161ef9c09bc76c31944e0a53</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVIyW4-_kAPRZBLLm40ki1Zx7JsPmAhl-QstPKoUbCtrWQH-u-jZrcJ9NDDoMP7zDviIeQrsO_AmLrOjHFgFQNdRmpZwRFZQi14BRr4MVmWvK2A63ZBTnN-YYxJaJoTshAgpGqlWJKnx2dMdofzFBxF79FNmUZPE-bXEkwp9jSMdJ1d4YJ7Dpa62IcqjN3ssKMFoTh2ccAphSlkOsQO-3Pyxds-48XhPSNPN-vH1V21ebi9X_3YVE6oZqoaUC1Y6ITbqlpa23hplZKcCS_qpvUavPcgWQ0S0GvH9NYp6QToukZmG3FGrva9uxR_zZgnM4TssO_tiHHOhnOpVK24EAW9_Ad9iXMay-_eKa60FKxQfE-5FHNO6M0uhcGm3waY-SPd7KWbIt28SzdQlr4dquftgN3Hyl_LBRB7IJdo_Inp8_Z_at8AUcWL5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2267279630</pqid></control><display><type>article</type><title>Therapeutic effects of resveratrol in Escherichia coli-induced rat endometritis model</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Demirel, Murside Ayse ; Han, Sevtap ; Tokmak, Aytekin ; Ercan Gokay, Nilufer ; Uludag, Mecit Orhan ; Yildirir Ustun, Tugçe ; Cicek, Ali Fuat</creator><creatorcontrib>Demirel, Murside Ayse ; Han, Sevtap ; Tokmak, Aytekin ; Ercan Gokay, Nilufer ; Uludag, Mecit Orhan ; Yildirir Ustun, Tugçe ; Cicek, Ali Fuat</creatorcontrib><description>Endometritis is an inflammatory disorder of the endometrial lining of the uterine tissue in postpartum stage. Endometritis mostly progresses subclinically and causes infertility through the disruption of the hormonal balance. It has been shown in many studies that resveratrol has anti-inflammatory and antioxidant properties. However, the possible beneficial effects of resveratrol in endometritis have not been determined yet. The aim of the present study is to evaluate the treatment potential of resveratrol in an experimentally induced endometritis model in rats. Endometritis was induced in 12-week-old female, nonpregnant, Sprague Dawley rats. The animals were divided into six groups: control (NaCl 0.9%) and endometritis (NaCl 0.9%), marbofloxacin + PGF
2α
, marbofloxacin, marbofloxacin + resveratrol, and resveratrol groups. To induce endometritis, 5 mg/kg/s.c. progesterone was given for 5 days, and then
Escherichia coli
(50 μl, 1 × 10
5
cfu/rat) was injected in the right cornu uteri following laparotomy. Sixteen hours after bacterial inoculation, the treatment protocol was applied for 14 days. At the end of the experiment, the total oxidant status (TOS) and total antioxidant status (TAS) were examined spectrophotometrically in uterus tissues. The severity of inflammation in uterus samples and follicular activity in ovarian tissues were histopathologically evaluated. In addition, serum cytokine levels were determined. While TAS in uterine tissue significantly increased in the resveratrol group when compared to that of the other groups (
p
< 0.05), there was no difference between the groups in TOS (
p
> 0.05). The inflammation of the endometrium and the numbers of corpus luteum in the endometritis group were highly significant when compared to those of the other groups (
p
< 0.05). The recovery of inflammation and follicular activity were similar to those of the other groups in resveratrol group. However, it was realized that resveratrol administration reduced serum cytokine levels. According to the results of the current study, resveratrol was found to be effective in the treatment of endometritis with its antioxidant and anti-inflammatory functions.</description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/s00210-019-01696-1</identifier><identifier>PMID: 31367863</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Bacteria ; Biomedical and Life Sciences ; Biomedicine ; Corpus luteum ; Cytokines ; Cytokines - blood ; Disruption ; E coli ; Endometritis ; Endometritis - blood ; Endometritis - drug therapy ; Endometritis - metabolism ; Endometritis - pathology ; Endometrium ; Escherichia coli ; Female ; Infertility ; Inflammation ; Inflammatory diseases ; Inoculation ; Neurosciences ; Original Article ; Ovary - drug effects ; Ovary - pathology ; Oxidative Stress - drug effects ; Pharmacology/Toxicology ; Postpartum ; Progesterone ; Rats ; Rats, Sprague-Dawley ; Resveratrol ; Resveratrol - pharmacology ; Resveratrol - therapeutic use ; Sodium chloride ; Spectrophotometry ; Tissues ; Uterus ; Uterus - drug effects ; Uterus - metabolism ; Uterus - pathology</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 2019-12, Vol.392 (12), p.1577-1589</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Naunyn-Schmiedeberg's Archives of Pharmacology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-51781a1d3cb746aa5f6a776203f3458f91fff1604161ef9c09bc76c31944e0a53</citedby><cites>FETCH-LOGICAL-c375t-51781a1d3cb746aa5f6a776203f3458f91fff1604161ef9c09bc76c31944e0a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00210-019-01696-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00210-019-01696-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31367863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demirel, Murside Ayse</creatorcontrib><creatorcontrib>Han, Sevtap</creatorcontrib><creatorcontrib>Tokmak, Aytekin</creatorcontrib><creatorcontrib>Ercan Gokay, Nilufer</creatorcontrib><creatorcontrib>Uludag, Mecit Orhan</creatorcontrib><creatorcontrib>Yildirir Ustun, Tugçe</creatorcontrib><creatorcontrib>Cicek, Ali Fuat</creatorcontrib><title>Therapeutic effects of resveratrol in Escherichia coli-induced rat endometritis model</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn-Schmiedeberg's Arch Pharmacol</addtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>Endometritis is an inflammatory disorder of the endometrial lining of the uterine tissue in postpartum stage. Endometritis mostly progresses subclinically and causes infertility through the disruption of the hormonal balance. It has been shown in many studies that resveratrol has anti-inflammatory and antioxidant properties. However, the possible beneficial effects of resveratrol in endometritis have not been determined yet. The aim of the present study is to evaluate the treatment potential of resveratrol in an experimentally induced endometritis model in rats. Endometritis was induced in 12-week-old female, nonpregnant, Sprague Dawley rats. The animals were divided into six groups: control (NaCl 0.9%) and endometritis (NaCl 0.9%), marbofloxacin + PGF
2α
, marbofloxacin, marbofloxacin + resveratrol, and resveratrol groups. To induce endometritis, 5 mg/kg/s.c. progesterone was given for 5 days, and then
Escherichia coli
(50 μl, 1 × 10
5
cfu/rat) was injected in the right cornu uteri following laparotomy. Sixteen hours after bacterial inoculation, the treatment protocol was applied for 14 days. At the end of the experiment, the total oxidant status (TOS) and total antioxidant status (TAS) were examined spectrophotometrically in uterus tissues. The severity of inflammation in uterus samples and follicular activity in ovarian tissues were histopathologically evaluated. In addition, serum cytokine levels were determined. While TAS in uterine tissue significantly increased in the resveratrol group when compared to that of the other groups (
p
< 0.05), there was no difference between the groups in TOS (
p
> 0.05). The inflammation of the endometrium and the numbers of corpus luteum in the endometritis group were highly significant when compared to those of the other groups (
p
< 0.05). The recovery of inflammation and follicular activity were similar to those of the other groups in resveratrol group. However, it was realized that resveratrol administration reduced serum cytokine levels. According to the results of the current study, resveratrol was found to be effective in the treatment of endometritis with its antioxidant and anti-inflammatory functions.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Bacteria</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Corpus luteum</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Disruption</subject><subject>E coli</subject><subject>Endometritis</subject><subject>Endometritis - blood</subject><subject>Endometritis - drug therapy</subject><subject>Endometritis - metabolism</subject><subject>Endometritis - pathology</subject><subject>Endometrium</subject><subject>Escherichia coli</subject><subject>Female</subject><subject>Infertility</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Inoculation</subject><subject>Neurosciences</subject><subject>Original Article</subject><subject>Ovary - drug effects</subject><subject>Ovary - pathology</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology/Toxicology</subject><subject>Postpartum</subject><subject>Progesterone</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Resveratrol</subject><subject>Resveratrol - pharmacology</subject><subject>Resveratrol - therapeutic use</subject><subject>Sodium chloride</subject><subject>Spectrophotometry</subject><subject>Tissues</subject><subject>Uterus</subject><subject>Uterus - drug effects</subject><subject>Uterus - metabolism</subject><subject>Uterus - pathology</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE1r3DAQhkVIyW4-_kAPRZBLLm40ki1Zx7JsPmAhl-QstPKoUbCtrWQH-u-jZrcJ9NDDoMP7zDviIeQrsO_AmLrOjHFgFQNdRmpZwRFZQi14BRr4MVmWvK2A63ZBTnN-YYxJaJoTshAgpGqlWJKnx2dMdofzFBxF79FNmUZPE-bXEkwp9jSMdJ1d4YJ7Dpa62IcqjN3ssKMFoTh2ccAphSlkOsQO-3Pyxds-48XhPSNPN-vH1V21ebi9X_3YVE6oZqoaUC1Y6ITbqlpa23hplZKcCS_qpvUavPcgWQ0S0GvH9NYp6QToukZmG3FGrva9uxR_zZgnM4TssO_tiHHOhnOpVK24EAW9_Ad9iXMay-_eKa60FKxQfE-5FHNO6M0uhcGm3waY-SPd7KWbIt28SzdQlr4dquftgN3Hyl_LBRB7IJdo_Inp8_Z_at8AUcWL5A</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Demirel, Murside Ayse</creator><creator>Han, Sevtap</creator><creator>Tokmak, Aytekin</creator><creator>Ercan Gokay, Nilufer</creator><creator>Uludag, Mecit Orhan</creator><creator>Yildirir Ustun, Tugçe</creator><creator>Cicek, Ali Fuat</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20191201</creationdate><title>Therapeutic effects of resveratrol in Escherichia coli-induced rat endometritis model</title><author>Demirel, Murside Ayse ; Han, Sevtap ; Tokmak, Aytekin ; Ercan Gokay, Nilufer ; Uludag, Mecit Orhan ; Yildirir Ustun, Tugçe ; Cicek, Ali Fuat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-51781a1d3cb746aa5f6a776203f3458f91fff1604161ef9c09bc76c31944e0a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Bacteria</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Corpus luteum</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Disruption</topic><topic>E coli</topic><topic>Endometritis</topic><topic>Endometritis - blood</topic><topic>Endometritis - drug therapy</topic><topic>Endometritis - metabolism</topic><topic>Endometritis - pathology</topic><topic>Endometrium</topic><topic>Escherichia coli</topic><topic>Female</topic><topic>Infertility</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Inoculation</topic><topic>Neurosciences</topic><topic>Original Article</topic><topic>Ovary - drug effects</topic><topic>Ovary - pathology</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology/Toxicology</topic><topic>Postpartum</topic><topic>Progesterone</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Resveratrol</topic><topic>Resveratrol - pharmacology</topic><topic>Resveratrol - therapeutic use</topic><topic>Sodium chloride</topic><topic>Spectrophotometry</topic><topic>Tissues</topic><topic>Uterus</topic><topic>Uterus - drug effects</topic><topic>Uterus - metabolism</topic><topic>Uterus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demirel, Murside Ayse</creatorcontrib><creatorcontrib>Han, Sevtap</creatorcontrib><creatorcontrib>Tokmak, Aytekin</creatorcontrib><creatorcontrib>Ercan Gokay, Nilufer</creatorcontrib><creatorcontrib>Uludag, Mecit Orhan</creatorcontrib><creatorcontrib>Yildirir Ustun, Tugçe</creatorcontrib><creatorcontrib>Cicek, Ali Fuat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demirel, Murside Ayse</au><au>Han, Sevtap</au><au>Tokmak, Aytekin</au><au>Ercan Gokay, Nilufer</au><au>Uludag, Mecit Orhan</au><au>Yildirir Ustun, Tugçe</au><au>Cicek, Ali Fuat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effects of resveratrol in Escherichia coli-induced rat endometritis model</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><stitle>Naunyn-Schmiedeberg's Arch Pharmacol</stitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>392</volume><issue>12</issue><spage>1577</spage><epage>1589</epage><pages>1577-1589</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><abstract>Endometritis is an inflammatory disorder of the endometrial lining of the uterine tissue in postpartum stage. Endometritis mostly progresses subclinically and causes infertility through the disruption of the hormonal balance. It has been shown in many studies that resveratrol has anti-inflammatory and antioxidant properties. However, the possible beneficial effects of resveratrol in endometritis have not been determined yet. The aim of the present study is to evaluate the treatment potential of resveratrol in an experimentally induced endometritis model in rats. Endometritis was induced in 12-week-old female, nonpregnant, Sprague Dawley rats. The animals were divided into six groups: control (NaCl 0.9%) and endometritis (NaCl 0.9%), marbofloxacin + PGF
2α
, marbofloxacin, marbofloxacin + resveratrol, and resveratrol groups. To induce endometritis, 5 mg/kg/s.c. progesterone was given for 5 days, and then
Escherichia coli
(50 μl, 1 × 10
5
cfu/rat) was injected in the right cornu uteri following laparotomy. Sixteen hours after bacterial inoculation, the treatment protocol was applied for 14 days. At the end of the experiment, the total oxidant status (TOS) and total antioxidant status (TAS) were examined spectrophotometrically in uterus tissues. The severity of inflammation in uterus samples and follicular activity in ovarian tissues were histopathologically evaluated. In addition, serum cytokine levels were determined. While TAS in uterine tissue significantly increased in the resveratrol group when compared to that of the other groups (
p
< 0.05), there was no difference between the groups in TOS (
p
> 0.05). The inflammation of the endometrium and the numbers of corpus luteum in the endometritis group were highly significant when compared to those of the other groups (
p
< 0.05). The recovery of inflammation and follicular activity were similar to those of the other groups in resveratrol group. However, it was realized that resveratrol administration reduced serum cytokine levels. According to the results of the current study, resveratrol was found to be effective in the treatment of endometritis with its antioxidant and anti-inflammatory functions.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31367863</pmid><doi>10.1007/s00210-019-01696-1</doi><tpages>13</tpages></addata></record> |
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| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 2019-12, Vol.392 (12), p.1577-1589 |
| issn | 0028-1298 1432-1912 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Bacteria Biomedical and Life Sciences Biomedicine Corpus luteum Cytokines Cytokines - blood Disruption E coli Endometritis Endometritis - blood Endometritis - drug therapy Endometritis - metabolism Endometritis - pathology Endometrium Escherichia coli Female Infertility Inflammation Inflammatory diseases Inoculation Neurosciences Original Article Ovary - drug effects Ovary - pathology Oxidative Stress - drug effects Pharmacology/Toxicology Postpartum Progesterone Rats Rats, Sprague-Dawley Resveratrol Resveratrol - pharmacology Resveratrol - therapeutic use Sodium chloride Spectrophotometry Tissues Uterus Uterus - drug effects Uterus - metabolism Uterus - pathology |
| title | Therapeutic effects of resveratrol in Escherichia coli-induced rat endometritis model |
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