Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1

Mutations of PTEN-induced kinase 1 (PINK1) cause recessive familial Parkinson's disease. Cells lacking PINK1 display mitochondrial deficits and increased sensitivity to oxidative and proteasomal stress. It has been shown that the 52-kDa (mature) form of PINK1 in the cytoplasm mitigates proteaso...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-09, Vol.517 (2), p.376-382
Hauptverfasser:	Sun, Liuke, Büeler, Hansruedi
Format:	Artikel
Sprache:	eng
Schlagworte:	Mono-ubiquitination Nuclear translocation Parkinson's disease PINK1 Proteasomal stress
Online-Zugang:	Volltext
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