Reductive Amination of Ketonic Compounds Catalyzed by CpIr(III) Complexes Bearing a Picolinamidato Ligand

Cp*Ir complexes bearing a 2-picolinamide moiety serve as effective catalysts for the direct reductive amination of ketonic compounds to give primary amines under transfer hydrogenation conditions using ammonium formate as both the nitrogen and hydrogen source. The clean and operationally simple tran...

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Veröffentlicht in:	Journal of organic chemistry 2019-09, Vol.84 (17), p.10962-10977
Hauptverfasser:	Tanaka, Kouichi, Miki, Takashi, Murata, Kunihiko, Yamaguchi, Ayumi, Kayaki, Yoshihito, Kuwata, Shigeki, Ikariya, Takao, Watanabe, Masahito
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container_end_page	10977
container_issue	17
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container_title	Journal of organic chemistry
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creator	Tanaka, Kouichi Miki, Takashi Murata, Kunihiko Yamaguchi, Ayumi Kayaki, Yoshihito Kuwata, Shigeki Ikariya, Takao Watanabe, Masahito
description	Cp*Ir complexes bearing a 2-picolinamide moiety serve as effective catalysts for the direct reductive amination of ketonic compounds to give primary amines under transfer hydrogenation conditions using ammonium formate as both the nitrogen and hydrogen source. The clean and operationally simple transformation proceeds with a substrate to catalyst molar ratio (S/C) of up to 20,000 at relatively low temperature and exhibits excellent chemoselectivity toward primary amines.
doi_str_mv	10.1021/acs.joc.9b01565
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title	Reductive Amination of Ketonic Compounds Catalyzed by CpIr(III) Complexes Bearing a Picolinamidato Ligand
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