Antenatal sildenafil treatment improves neonatal pulmonary hemodynamics and gas exchange in lambs with diaphragmatic hernia

ABSTRACT Objectives Infants with congenital diaphragmatic hernia (CDH) are predisposed to pulmonary hypertension after birth, owing to lung hypoplasia that impairs fetal pulmonary vascular development. Antenatal sildenafil treatment attenuates abnormal pulmonary vascular and alveolar development in...

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Veröffentlicht in:	Ultrasound in obstetrics & gynecology 2019-10, Vol.54 (4), p.506-516
Hauptverfasser:	Kashyap, A. J., Dekoninck, P. L. J., Rodgers, K. A., Thio, M., Mcgillick, E. V., Amberg, B. J., Skinner, S. M., Moxham, A. M., Russo, F. M., Deprest, J. A., Hooper, S. B., Crossley, K. J., Hodges, R. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autopsy - methods Blood Gas Analysis - methods congenital abnormality Female Fetal Therapies - methods fetal therapy Fetus Hemodynamics - drug effects Hernias, Diaphragmatic, Congenital - drug therapy Hernias, Diaphragmatic, Congenital - physiopathology Lung - blood supply Lung - drug effects Lung - physiopathology Models, Animal neonatal transition Phosphodiesterase 5 Inhibitors - administration & dosage Phosphodiesterase 5 Inhibitors - blood Phosphodiesterase 5 Inhibitors - pharmacology Pregnancy Prenatal Care Pulmonary Gas Exchange - drug effects pulmonary hypertension pulmonary vascular development Sheep Sildenafil Citrate - administration & dosage Sildenafil Citrate - blood Sildenafil Citrate - pharmacology
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