The Biological Effects of Interleukin-17A on Adhesion Molecules Expression and Foam Cell Formation in Atherosclerotic Lesions

Interleukin-17A (IL-17A), a major effector cytokine secreted by T helper 17 (Th17) cells, is elevated in atherosclerosis lesions. The purpose of this study was to assess the role of IL-17A in the pathogenesis of atherosclerosis. To measure the expression of adhesion molecules, human umbilical vein e...

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Veröffentlicht in:	Journal of interferon & cytokine research 2019-11, Vol.39 (11), p.694-702
Hauptverfasser:	Shiotsugu, Shohei, Okinaga, Toshinori, Habu, Manabu, Yoshiga, Daigo, Yoshioka, Izumi, Nishihara, Tatsuji, Ariyoshi, Wataru
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Adhesion Antigens Arteriosclerosis Atherosclerosis Biological effects Cell adhesion Cell adhesion & migration Cell adhesion molecules Cytokines Endothelial cells Endothelium Gene expression Helper cells Intercellular adhesion molecule 1 Interleukins Lesions Leukocytes LFA-1 antigen Liquid oxygen Low density lipoprotein LOX-1 protein Lymphocytes Lymphocytes T Mac1 protein Macrophages Manufacturing cells Monocytes mRNA Pathogenesis Phorbol 12-myristate 13-acetate Polymerase chain reaction Scavenger receptors siRNA Transfection Umbilical vein Vascular cell adhesion molecule 1 VLA-4 antigen
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