Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production

The skin permeability barrier is indispensable for maintaining water inside the body and preventing the invasion of pathogens and allergens; abnormalities lead to skin disorders such as atopic dermatitis and ichthyosis. Acylceramide is an essential lipid for skin barrier formation, and CYP4F22 is a...

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Veröffentlicht in:	Journal of investigative dermatology 2020-02, Vol.140 (2), p.319-326.e4
Hauptverfasser:	Miyamoto, Masatoshi, Itoh, Narumi, Sawai, Megumi, Sassa, Takayuki, Kihara, Akio
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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