Interdomain twists of human thymidine phosphorylase and its active–inactive conformations: Binding of 5‐FU and its analogues to human thymidine phosphorylase versus dihydropyrimidine dehydrogenase

5‐fluorouracil (5‐FU) is an anticancer drug, which inhibits human thymidine phosphorylase (hTP) and plays a key role in maintaining the process of DNA replication and repair. It is involved in regulating pyrimidine nucleotide production, by which it inhibits the mechanism of cell proliferation and c...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical biology & drug design 2019-09, Vol.94 (5), p.1956-1972
Hauptverfasser:	Tozer, Tiffany, Heale, Kali, Manto Chagas, Caroline, Barros, Andre Luis Branco, Alisaraie, Laleh
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐Fluorouracil computational biology dihydropyrimidine dehydrogenase enzyme activation human thymidine phosphorylase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!