N-dihydrogalactochitosan as immune and direct antitumor agent amplifying the effects of photodynamic therapy and photodynamic therapy-generated vaccines

It is becoming apparent that to obtain robust and prolonged antitumor responses in cancer immunotherapy, appropriate adjunct agents promoting both tumor antigen delivery and immune rejection enhancement are critically required. The semisynthetic biopolymer N-dihydrogalactochitosan (GC) is emerging a...

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Veröffentlicht in:	International immunopharmacology 2019-10, Vol.75, p.105764-105764, Article 105764
Hauptverfasser:	Korbelik, Mladen, Banáth, Judit, Zhang, Wei, Gallagher, Paul, Hode, Tomas, Lam, Samuel S.K., Chen, Wei R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adjuvants, Immunologic - therapeutic use Animals Anticancer properties Antigens Antineoplastic Agents - therapeutic use Antitumor activity Biopolymers Cancer Cancer immunotherapy Cancer vaccines Cancer Vaccines - therapeutic use Carcinoma, Squamous Cell - drug therapy Caspase Caspase-1 Cell death Chitosan - analogs & derivatives Chitosan - therapeutic use Combined vaccines Cryoablation therapy Cryosurgery Fluorescence Fluorescence microscopy Glycated chitosan Guanylate cyclase Head and Neck Neoplasms - drug therapy Immunoadjuvant Immunoregulatory cells Immunotherapy In vitro methods and tests Lipids Mice, Inbred C3H Photochemotherapy Photodynamic therapy Photosensitizing Agents - therapeutic use SCCVII tumor cells Squamous cell carcinoma Suppressor cells Tumor Cells, Cultured Vaccines
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