Antiparasitic effect of (−)-α-bisabolol against Trypanosoma cruzi Y strain forms

Chagas disease is caused by Trypanosoma cruzi and affects about 7 million people worldwide. Benznidazole and nifurtimox have low efficacy and high toxicity. The present study was designed to identify the trypanocidal effect of (−)-α-Bisabolol (BIS) and investigate its mechanism. Epimastigotes and tr...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2019-11, Vol.95 (3), p.114860-114860, Article 114860
Hauptverfasser:	de Menezes, Ramon R.P.P.B., Sampaio, Tiago L., Lima, Danya B., Sousa, Paloma L., de Azevedo, Isabella E.P., Magalhães, Emanuel P., Tessarolo, Louise D., Marinho, Márcia Machado, dos Santos, Ricardo Pires, Martins, Alice M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Bisabolol Cell Line Cell Survival - drug effects Chagas Disease - drug therapy Chagas Disease - parasitology Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - antagonists & inhibitors Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - metabolism Inhibitory Concentration 50 Macaca mulatta Molecular Docking Simulation Molecular Structure Monocyclic Sesquiterpenes - chemistry Monocyclic Sesquiterpenes - pharmacology Oxidative Stress - drug effects Trypanocidal Agents - pharmacology Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - physiology
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