Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti‐inflammatory, anti‐oxidative, and anti‐protease pathways
The scopoletin (coumarin) and epicatechin (flavonoid) rich Morinda citrifolia L. (MC) Noni leaves are non‐toxic (unlike the fruits) and consumed as vegetables. The anti‐osteoarthritis effects of the MC leaf extract against joint cartilage degradation and inflammation were investigated through cartil...
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Veröffentlicht in: | Journal of food biochemistry 2019-03, Vol.43 (3), p.e12755-n/a |
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creator | Wan Osman, Wan NurFarahin Che Ahmad Tantowi, Nur Adeelah Lau, Seng Fong Mohamed, Suhaila |
description | The scopoletin (coumarin) and epicatechin (flavonoid) rich Morinda citrifolia L. (MC) Noni leaves are non‐toxic (unlike the fruits) and consumed as vegetables. The anti‐osteoarthritis effects of the MC leaf extract against joint cartilage degradation and inflammation were investigated through cartilage explant cultures and pre‐clinical animal study. Osteoarthritis were induced by intra‐articular monosodium iodoacetate injection into the right knee. The extract, scopoletin and epicatechin, suppressed glycosaminoglycan and nitric oxide release from the cartilage explant in the presence of Interleukin‐1β. After 28 days, the extract treatment reduced the in vivo serum levels and joint tissues mRNA expressions for joint cartilage degradation, aggrecanase, and collagenase biomarkers. The extract increased the bone formation marker PINP levels, besides improving the articular cartilage structure and chondrocytes cellularity. The extract improved bone formation/repair, subchondral bone structure, strength and integrity, as well as cartilage synthesis by suppressing inflammation, nitric oxide production, joint catabolism by proteases, and oxidative stress.
Practical applications
The scopoletin (coumarin) and epicatechin (flavonoid) rich Morinda citrifolia (Noni) leaves may be used as vegetables, functional food ingredient, or dietary supplements to suppress osteoarthritis progression against joint cartilage degradation and inflammation. The extract, scopoletin, or epicatechin, suppressed glycosaminoglycan, and nitric oxide release from the cartilage. The Morinda citrifolia leaf extract suppressed inflammation, nitric oxide production, tissues catabolism by proteases and oxidative stress to help reduce joint cartilage degradation, besides improving the articular cartilage structure, chondrocytes health, subchondral bone structure, bone formation/repair, and cartilage synthesis. |
doi_str_mv | 10.1111/jfbc.12755 |
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Practical applications
The scopoletin (coumarin) and epicatechin (flavonoid) rich Morinda citrifolia (Noni) leaves may be used as vegetables, functional food ingredient, or dietary supplements to suppress osteoarthritis progression against joint cartilage degradation and inflammation. The extract, scopoletin, or epicatechin, suppressed glycosaminoglycan, and nitric oxide release from the cartilage. The Morinda citrifolia leaf extract suppressed inflammation, nitric oxide production, tissues catabolism by proteases and oxidative stress to help reduce joint cartilage degradation, besides improving the articular cartilage structure, chondrocytes health, subchondral bone structure, bone formation/repair, and cartilage synthesis.</description><identifier>ISSN: 0145-8884</identifier><identifier>EISSN: 1745-4514</identifier><identifier>DOI: 10.1111/jfbc.12755</identifier><identifier>PMID: 31353568</identifier><language>eng</language><publisher>United States</publisher><subject>Arthritis ; articular cartilage ; epicatechin ; inflammation ; Morinda citrifolia ; scopoletin</subject><ispartof>Journal of food biochemistry, 2019-03, Vol.43 (3), p.e12755-n/a</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3295-f16a4e48183c7148ac653cf8c91455627d9715710b470d6b1c1c8a5b0be53c423</citedby><cites>FETCH-LOGICAL-c3295-f16a4e48183c7148ac653cf8c91455627d9715710b470d6b1c1c8a5b0be53c423</cites><orcidid>0000-0002-2954-3821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjfbc.12755$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjfbc.12755$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31353568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wan Osman, Wan NurFarahin</creatorcontrib><creatorcontrib>Che Ahmad Tantowi, Nur Adeelah</creatorcontrib><creatorcontrib>Lau, Seng Fong</creatorcontrib><creatorcontrib>Mohamed, Suhaila</creatorcontrib><title>Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti‐inflammatory, anti‐oxidative, and anti‐protease pathways</title><title>Journal of food biochemistry</title><addtitle>J Food Biochem</addtitle><description>The scopoletin (coumarin) and epicatechin (flavonoid) rich Morinda citrifolia L. (MC) Noni leaves are non‐toxic (unlike the fruits) and consumed as vegetables. The anti‐osteoarthritis effects of the MC leaf extract against joint cartilage degradation and inflammation were investigated through cartilage explant cultures and pre‐clinical animal study. Osteoarthritis were induced by intra‐articular monosodium iodoacetate injection into the right knee. The extract, scopoletin and epicatechin, suppressed glycosaminoglycan and nitric oxide release from the cartilage explant in the presence of Interleukin‐1β. After 28 days, the extract treatment reduced the in vivo serum levels and joint tissues mRNA expressions for joint cartilage degradation, aggrecanase, and collagenase biomarkers. The extract increased the bone formation marker PINP levels, besides improving the articular cartilage structure and chondrocytes cellularity. The extract improved bone formation/repair, subchondral bone structure, strength and integrity, as well as cartilage synthesis by suppressing inflammation, nitric oxide production, joint catabolism by proteases, and oxidative stress.
Practical applications
The scopoletin (coumarin) and epicatechin (flavonoid) rich Morinda citrifolia (Noni) leaves may be used as vegetables, functional food ingredient, or dietary supplements to suppress osteoarthritis progression against joint cartilage degradation and inflammation. The extract, scopoletin, or epicatechin, suppressed glycosaminoglycan, and nitric oxide release from the cartilage. The Morinda citrifolia leaf extract suppressed inflammation, nitric oxide production, tissues catabolism by proteases and oxidative stress to help reduce joint cartilage degradation, besides improving the articular cartilage structure, chondrocytes health, subchondral bone structure, bone formation/repair, and cartilage synthesis.</description><subject>Arthritis</subject><subject>articular cartilage</subject><subject>epicatechin</subject><subject>inflammation</subject><subject>Morinda citrifolia</subject><subject>scopoletin</subject><issn>0145-8884</issn><issn>1745-4514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kctuEzEUhi0EoqGw4QGQlwUlxR5fZrIsUctFhW5gPTrjOUNceezBdtpmxyPwODwPT4LTpCzxxvavT5-Ozk_IS85OeTlvr4fOnPKqVuoRmfFaqoVUXD4mM8bLu2kaeUSepXTNGKuWWj4lR4ILJZRuZuT3-WQNZDRr6yn4niYTpuAwl2-0Zk0_h2h9D9TYHO0QnAV68iV4-5o6hIHiXY5gMk2baXI4os-QbfBzOtpsvxdxT69SxgAxr2OJEr0pBvDZ_vn5y_rBwThCDnE7fwjDne2L4wbn9_Mc0imGjJCQTpDXt7BNz8mTAVzCF4f7mHy7OP-6-rC4vHr_cXV2uTCiWqrFwDVIlA1vhKm5bMBoJczQmGXZjdJV3S9rrmrOOlmzXnfccNOA6liHhZOVOCYne2-Z4McGU25Hmww6Bx7DJrVVpbUQmrMd-maPmhhSiji0U7QjxG3LWbtrqt011d43VeBXB--mG7H_hz5UUwC-B26tw-1_VO2ni3ervfQvhA2lTA</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Wan Osman, Wan NurFarahin</creator><creator>Che Ahmad Tantowi, Nur Adeelah</creator><creator>Lau, Seng Fong</creator><creator>Mohamed, Suhaila</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2954-3821</orcidid></search><sort><creationdate>201903</creationdate><title>Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti‐inflammatory, anti‐oxidative, and anti‐protease pathways</title><author>Wan Osman, Wan NurFarahin ; Che Ahmad Tantowi, Nur Adeelah ; Lau, Seng Fong ; Mohamed, Suhaila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3295-f16a4e48183c7148ac653cf8c91455627d9715710b470d6b1c1c8a5b0be53c423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Arthritis</topic><topic>articular cartilage</topic><topic>epicatechin</topic><topic>inflammation</topic><topic>Morinda citrifolia</topic><topic>scopoletin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wan Osman, Wan NurFarahin</creatorcontrib><creatorcontrib>Che Ahmad Tantowi, Nur Adeelah</creatorcontrib><creatorcontrib>Lau, Seng Fong</creatorcontrib><creatorcontrib>Mohamed, Suhaila</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of food biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wan Osman, Wan NurFarahin</au><au>Che Ahmad Tantowi, Nur Adeelah</au><au>Lau, Seng Fong</au><au>Mohamed, Suhaila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti‐inflammatory, anti‐oxidative, and anti‐protease pathways</atitle><jtitle>Journal of food biochemistry</jtitle><addtitle>J Food Biochem</addtitle><date>2019-03</date><risdate>2019</risdate><volume>43</volume><issue>3</issue><spage>e12755</spage><epage>n/a</epage><pages>e12755-n/a</pages><issn>0145-8884</issn><eissn>1745-4514</eissn><abstract>The scopoletin (coumarin) and epicatechin (flavonoid) rich Morinda citrifolia L. (MC) Noni leaves are non‐toxic (unlike the fruits) and consumed as vegetables. The anti‐osteoarthritis effects of the MC leaf extract against joint cartilage degradation and inflammation were investigated through cartilage explant cultures and pre‐clinical animal study. Osteoarthritis were induced by intra‐articular monosodium iodoacetate injection into the right knee. The extract, scopoletin and epicatechin, suppressed glycosaminoglycan and nitric oxide release from the cartilage explant in the presence of Interleukin‐1β. After 28 days, the extract treatment reduced the in vivo serum levels and joint tissues mRNA expressions for joint cartilage degradation, aggrecanase, and collagenase biomarkers. The extract increased the bone formation marker PINP levels, besides improving the articular cartilage structure and chondrocytes cellularity. The extract improved bone formation/repair, subchondral bone structure, strength and integrity, as well as cartilage synthesis by suppressing inflammation, nitric oxide production, joint catabolism by proteases, and oxidative stress.
Practical applications
The scopoletin (coumarin) and epicatechin (flavonoid) rich Morinda citrifolia (Noni) leaves may be used as vegetables, functional food ingredient, or dietary supplements to suppress osteoarthritis progression against joint cartilage degradation and inflammation. The extract, scopoletin, or epicatechin, suppressed glycosaminoglycan, and nitric oxide release from the cartilage. The Morinda citrifolia leaf extract suppressed inflammation, nitric oxide production, tissues catabolism by proteases and oxidative stress to help reduce joint cartilage degradation, besides improving the articular cartilage structure, chondrocytes health, subchondral bone structure, bone formation/repair, and cartilage synthesis.</abstract><cop>United States</cop><pmid>31353568</pmid><doi>10.1111/jfbc.12755</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2954-3821</orcidid></addata></record> |
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subjects | Arthritis articular cartilage epicatechin inflammation Morinda citrifolia scopoletin |
title | Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti‐inflammatory, anti‐oxidative, and anti‐protease pathways |
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