Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 88 Mexicans from the state of Querétaro living in the city of Querétaro (N = 45) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the m...
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| Veröffentlicht in: | Human immunology 2020-09, Vol.81 (9), p.522-524 |
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| creator | Martínez-Álvarez, Julio César Barquera, Rodrigo Hernández-Zaragoza, Diana Iraíz Bravo-Acevedo, Alicia Clayton, Stephen Arrieta-Bolaños, Esteban Immel, Alexander Benítez-Arvizu, Gamaliel Arrazola-García, María Araceli Juárez-Barreto, Vicencio Vega-Martínez, María del Rosario Juárez-Nicolás, Francisco Escutia-González, Ariadna Berenice Martínez-Bezies, Virginia García-Álvarez, Raquel Salgado-Galicia, Norma Zúñiga, Joaquín Yunis, Edmond J. Bekker-Méndez, Carolina Granados, Julio |
| description | We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 88 Mexicans from the state of Querétaro living in the city of Querétaro (N = 45) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Querétaro include seven Native American, two European and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Querétaro are Native American (51.82 ± 4.42% by ML; 42.61% of Native American haplotypes) and European (48.18 ± 3.55% by ML; 46.02% of European haplotypes), with a virtually absent African genetic component (0.00 ± 4.25% by ML; 4.55% of African haplotypes). |
| doi_str_mv | 10.1016/j.humimm.2019.07.296 |
| format | Article |
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We find that the most frequent haplotypes in the state of Querétaro include seven Native American, two European and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Querétaro are Native American (51.82 ± 4.42% by ML; 42.61% of Native American haplotypes) and European (48.18 ± 3.55% by ML; 46.02% of European haplotypes), with a virtually absent African genetic component (0.00 ± 4.25% by ML; 4.55% of African haplotypes).</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2019.07.296</identifier><identifier>PMID: 31353129</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Admixture ; HLA ; Immunogenetics ; Population genetics ; Querétaro</subject><ispartof>Human immunology, 2020-09, Vol.81 (9), p.522-524</ispartof><rights>2019 American Society for Histocompatibility and Immunogenetics</rights><rights>Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. 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We find that the most frequent haplotypes in the state of Querétaro include seven Native American, two European and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Querétaro are Native American (51.82 ± 4.42% by ML; 42.61% of Native American haplotypes) and European (48.18 ± 3.55% by ML; 46.02% of European haplotypes), with a virtually absent African genetic component (0.00 ± 4.25% by ML; 4.55% of African haplotypes).</description><subject>Admixture</subject><subject>HLA</subject><subject>Immunogenetics</subject><subject>Population genetics</subject><subject>Querétaro</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kM1q3DAUhUVp6EySvkEoWnYRO_rxyFYXhWHIH0wIgXQtZOmaaLAtV5LTziPlOfJi8TBpmVVWF8459x7uh9AZJTklVFxs8qexc12XM0JlTsqcSfEJzWlVyoxSIT6j-WRUWVUt5Awdx7ghhJSkLL6gGad8wSmTczRcQw_JGWzdM4To0hb7Bt-slzhuY4IOux6nPx4PfhhbnZzvI26C7_DDCOH1Jengz_Ed_HXG_zjQsNld0r3FYQy6PXBO0VGj2whf3-cJ-nV1-bi6ydb317er5TozXLCUSSstLawWrC6IFLJYCNsseAlSspJNEmuAW1kJKipqKkZLKTQjGuq6ZlDV_AR9398dgv89Qkyqc9FA2-oe_BgVY0JwXsiCTdFiHzXBxxigUUNwnQ5bRYnasVYbtWetdqwVKdXEelr79t4w1h3Y_0v_4E6Bn_sATH8-OwgqGge9AesCmKSsdx83vAGoK5Sk</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Martínez-Álvarez, Julio César</creator><creator>Barquera, Rodrigo</creator><creator>Hernández-Zaragoza, Diana Iraíz</creator><creator>Bravo-Acevedo, Alicia</creator><creator>Clayton, Stephen</creator><creator>Arrieta-Bolaños, Esteban</creator><creator>Immel, Alexander</creator><creator>Benítez-Arvizu, Gamaliel</creator><creator>Arrazola-García, María Araceli</creator><creator>Juárez-Barreto, Vicencio</creator><creator>Vega-Martínez, María del Rosario</creator><creator>Juárez-Nicolás, Francisco</creator><creator>Escutia-González, Ariadna Berenice</creator><creator>Martínez-Bezies, Virginia</creator><creator>García-Álvarez, Raquel</creator><creator>Salgado-Galicia, Norma</creator><creator>Zúñiga, Joaquín</creator><creator>Yunis, Edmond J.</creator><creator>Bekker-Méndez, Carolina</creator><creator>Granados, Julio</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200901</creationdate><title>Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro</title><author>Martínez-Álvarez, Julio César ; 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| subjects | Admixture HLA Immunogenetics Population genetics Querétaro |
| title | Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro |
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