The effect of the saturation degree of phospholipid on the formation of a novel self-assembled nano-micellar complex carrier with enhanced intestinal permeability

[Display omitted] The aim of this research was to formulate a novel nano-micellar complex carrier with intrinsically enhanced intestinal permeability for rosuvastatin calcium (RSV); as a model of BCS class III active pharmaceutical ingredients (APIs). The model drug is used primarily for treating hy...

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Veröffentlicht in:	International journal of pharmaceutics 2019-10, Vol.569, p.118567-118567, Article 118567
Hauptverfasser:	Ahmed, Mohammed Abdallah, Al-mahallawi, Abdulaziz Mohsen, El-Helaly, Sara Nageeb, Abd-Elsalam, Wessam Hamdy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Availability Caco-2 Cells Complex micelles Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Dynamics simulations Humans Intestinal Absorption - drug effects Male Micelles Molecular Docking Simulation Nano-micellar carrier Permeability - drug effects Phospholipids Phospholipids - administration & dosage Phospholipids - chemistry Phospholipids - pharmacokinetics Rats, Wistar Rosuvastatin calcium
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