Increased ILC3s associated with higher levels of IL‐1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

The role of redox regulation in immune‐mediated arthritis has been previously described. However, the relationship between innate immune cells, including innate lymphoid cells (ILCs) and phagocyte‐derived ROS, in this process remains unclear. Here, we characterize ILCs and measure the IL‐1 family cy...

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Veröffentlicht in:	European journal of immunology 2019-11, Vol.49 (11), p.2063-2073
Hauptverfasser:	Chan, Tzu‐Yi, Yen, Chia‐Liang, Huang, Ya‐Fang, Lo, Pei‐Chi, Nigrovic, Peter A., Cheng, Chia‐Ying, Wang, Wei‐Zhi, Wu, Szu‐Yu, Shieh, Chi‐Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonists Antirheumatic Agents - pharmacology Arthritis Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Experimental - pathology chronic granulomatous disease CYBB protein Cytokines Gene Expression Regulation - immunology Immune response Immunity, Innate - drug effects Inflammation innate lymphoid cells Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-1beta - genetics Interleukin-1beta - immunology Joint diseases Lymphocytes - drug effects Lymphocytes - immunology Lymphocytes - pathology Lymphoid cells Male Mice Mice, Inbred C57BL Mice, Knockout NAD(P)H oxidase NADPH oxidase NADPH Oxidase 2 - deficiency NADPH Oxidase 2 - genetics NADPH Oxidase 2 - immunology Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology Oxidation-Reduction - drug effects Phagocytes Phagocytes - drug effects Phagocytes - immunology Phagocytes - pathology reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - immunology Serum - immunology serum‐induced arthritis Signal Transduction T-Box Domain Proteins - genetics T-Box Domain Proteins - immunology Tarsus, Animal - drug effects Tarsus, Animal - immunology Tarsus, Animal - pathology
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