Implications of Necroptosis for Cardiovascular Diseases

Summary Necroptosis is a non-apoptotic programmed cell death pathway, which causes necrosis-like morphologic changes and triggers inflammation in the surrounding tissues. Accumulating evidence has demonstrated that necroptosis is involved in a number of pathological processes that lead to cardiovasc...

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Veröffentlicht in:Current medical science 2019-08, Vol.39 (4), p.513-522
Hauptverfasser: Ruan, Zhao-hui, Xu, Zi-xuan, Zhou, Xue-yun, Zhang, Xian, Shang, Lei
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container_end_page 522
container_issue 4
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container_title Current medical science
container_volume 39
creator Ruan, Zhao-hui
Xu, Zi-xuan
Zhou, Xue-yun
Zhang, Xian
Shang, Lei
description Summary Necroptosis is a non-apoptotic programmed cell death pathway, which causes necrosis-like morphologic changes and triggers inflammation in the surrounding tissues. Accumulating evidence has demonstrated that necroptosis is involved in a number of pathological processes that lead to cardiovascular diseases. However, the exact molecular pathways linking them remain unknown. Herein, this review summarizes the necroptosis-related pathways involved in the development of various cardiovascular diseases, including atherosclerosis, cardiac ischemia-reperfusion injury, cardiac hypertrophy, dilated cardiomyopathy and myocardial infarction, and may shed light on the diagnosis and treatment of these diseases.
doi_str_mv 10.1007/s11596-019-2067-6
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subjects Apoptosis - genetics
Atherosclerosis - genetics
Atherosclerosis - physiopathology
Cardiomegaly - genetics
Cardiomegaly - physiopathology
Cardiomyopathy, Dilated - genetics
Cardiomyopathy, Dilated - physiopathology
Cardiovascular Diseases - genetics
Cardiovascular Diseases - physiopathology
Cell Death - genetics
Humans
Medicine
Medicine & Public Health
Myocardial Infarction - genetics
Myocardial Infarction - physiopathology
Necroptosis - genetics
Reperfusion Injury - genetics
Reperfusion Injury - physiopathology
Signal Transduction - genetics
title Implications of Necroptosis for Cardiovascular Diseases
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