Norursodeoxycholic acid versus placebo in the treatment of non-alcoholic fatty liver disease: a double-blind, randomised, placebo-controlled, phase 2 dose-finding trial

Norursodeoxycholic acid is an orally administered side chain-shortened homologue of ursodeoxycholic acid that undergoes hepatic enrichment with hepatoprotective, anti-inflammatory, and antifibrotic activity. We assessed the efficacy of two doses of norursodeoxycholic acid versus placebo for the trea...

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Veröffentlicht in:	The lancet. Gastroenterology & hepatology 2019-10, Vol.4 (10), p.781-793
Hauptverfasser:	Traussnigg, Stefan, Schattenberg, Jörn M, Demir, Münevver, Wiegand, Johannes, Geier, Andreas, Teuber, Gerlinde, Hofmann, Wolf Peter, Kremer, Andreas E, Spreda, Frank, Kluwe, Johannes, Petersen, Jörg, Boettler, Tobias, Rainer, Florian, Halilbasic, Emina, Greinwald, Roland, Pröls, Markus, Manns, Michael P, Fickert, Peter, Trauner, Michael, Vogel, Wolfgang, Aigner, Elmar, Datz, Christian, Tilg, Herbert, Gerken, Guido, Rust, Christian, Cordes, Hans-Jörg, Steib, Christian, Pathil-Warth, Anita, Prinz, MD, Christian, Lammert, Frank, Antoni, Christoph, Klausmann, Gerhard, Häussinger, Dieter, Zipprich, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alanine Transaminase - blood Aspartate Aminotransferases - blood Blood Glucose - metabolism Cholagogues and Choleretics - administration & dosage Cholagogues and Choleretics - adverse effects Cholagogues and Choleretics - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Female Humans Lipids - blood Male Middle Aged Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - drug therapy Treatment Outcome Ursodeoxycholic Acid - administration & dosage Ursodeoxycholic Acid - adverse effects Ursodeoxycholic Acid - analogs & derivatives Ursodeoxycholic Acid - therapeutic use
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