Antibiotics drug release controlling and osteoblast adhesion from Titania nanotubes arrays using silk fibroin coating
Bacterial infection, wide inflammation, and osteoporosis are the most common factors in the failure of orthopedic implants. The present study aims to design an orthopedic implant based on Titania nanotubes (TiO2-NTs) which not only have a high biocompatibility but also are characterized by anti-bact...
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| Veröffentlicht in: | Materials Science & Engineering C 2019-10, Vol.103, p.109743-109743, Article 109743 |
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| creator | Fathi, Mehdi Akbari, Babak Taheriazam, Afshin |
| description | Bacterial infection, wide inflammation, and osteoporosis are the most common factors in the failure of orthopedic implants. The present study aims to design an orthopedic implant based on Titania nanotubes (TiO2-NTs) which not only have a high biocompatibility but also are characterized by anti-bacterial property. In order to improve the osseointegration of the TiO2-NTs structures (110–120 nm in diameter, 40 μm in length), they were used to coat the Titania implant by electrochemical anodizing. Vancomycin, which is soluble in water, was loaded as a main clinical drug to control intensive infections caused by positive gram bacteria. For the first time, Silk Fibroin (SF) Nanofibers coating was used to control drug release by the implementation of electrospinning on the TiO2-NTs surface. In order to investigate the anti-bacterial activities, S. aureus bacterium culture test was used. The cell culture of MG63 was conducted for both coated and non-coated samples of TiO2-NTs. The results showed that the SF Nanofibers coating not only controls the drug being freely released from TiO2-NTs but also effects adhesion and development of osteoblast cells. In this regard, this coating inhibits biofilm formation and development, as well as bacteria colonization due to anti-bacterial drug release. Therefore, this system can be considered as a promising alternative for orthopedic implants, preventing bone infection, osteomyelitis, bone cancer treatment, and other orthopedic diseases.
[Display omitted]
•Preparation and coating of TiO2-NTs by electrochemical anodization method•Improved surface Wettability of TiO2-NTs studied by Contact Angle•Change in physicochemical surface properties of Titania nano-structures as a function of various diameters for drug loading•Study and Characterization of Surface Morphology by Atomic Force Microscopy•Coating of SF nanofibers on TiO2-NTs, by electrospinning technique•promoting osteoblast cell adhesion on the TiO2-NTs and SF nanofibers•TiO2-NTs implants could act as potential biocompatible drug carriers•Desirable and sustained release of Vancomycin from TiO2-NTs•All samples show antibacterial activity against Staphylococcus aureus•Results suggest a promising platform for biomedical applications |
| doi_str_mv | 10.1016/j.msec.2019.109743 |
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[Display omitted]
•Preparation and coating of TiO2-NTs by electrochemical anodization method•Improved surface Wettability of TiO2-NTs studied by Contact Angle•Change in physicochemical surface properties of Titania nano-structures as a function of various diameters for drug loading•Study and Characterization of Surface Morphology by Atomic Force Microscopy•Coating of SF nanofibers on TiO2-NTs, by electrospinning technique•promoting osteoblast cell adhesion on the TiO2-NTs and SF nanofibers•TiO2-NTs implants could act as potential biocompatible drug carriers•Desirable and sustained release of Vancomycin from TiO2-NTs•All samples show antibacterial activity against Staphylococcus aureus•Results suggest a promising platform for biomedical applications</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2019.109743</identifier><identifier>PMID: 31349530</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adhesion ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacokinetics ; Antibiotics ; Bacteria ; Bacterial infections ; Biocompatibility ; Biofilms ; Biomedical materials ; Bone cancer ; Bone implants ; Cell Adhesion - drug effects ; Cell culture ; Cell Line ; Cell Proliferation - drug effects ; Coated Materials, Biocompatible - chemistry ; Coated Materials, Biocompatible - pharmacokinetics ; Coating ; Coatings ; Colonization ; Drug Carriers - chemistry ; Drug Carriers - pharmacokinetics ; Drug delivery ; Drug delivery systems ; Drug Liberation ; Electrochemistry ; Fibroins - chemistry ; Gram-negative bacteria ; Humans ; Infections ; Materials science ; Medical treatment ; Microscopy, Atomic Force ; Nanofibers ; Nanotechnology ; Nanotubes ; Nanotubes - chemistry ; Orthopaedic implants ; Orthopedics ; Osseointegration ; Osteoblasts - cytology ; Osteoblasts - drug effects ; Osteomyelitis ; Osteoporosis ; Silk ; Silk fibroin ; Silk Fibroin Nanofibers ; Staphylococcus aureus - drug effects ; Surface Properties ; Surgical implants ; Titania nanotubes ; Titanium - chemistry ; Titanium dioxide ; Titanium implants ; Transplants & implants ; Vancomycin ; Vancomycin - administration & dosage ; Vancomycin - pharmacokinetics</subject><ispartof>Materials Science & Engineering C, 2019-10, Vol.103, p.109743-109743, Article 109743</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Oct 2019</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-74ca6ac73a74e8bee2de71de386991ca6f6a1eede55792a1d520997d7f50f5493</citedby><cites>FETCH-LOGICAL-c384t-74ca6ac73a74e8bee2de71de386991ca6f6a1eede55792a1d520997d7f50f5493</cites><orcidid>0000-0002-7175-3742 ; 0000-0002-3764-6855</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0928493118338633$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31349530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fathi, Mehdi</creatorcontrib><creatorcontrib>Akbari, Babak</creatorcontrib><creatorcontrib>Taheriazam, Afshin</creatorcontrib><title>Antibiotics drug release controlling and osteoblast adhesion from Titania nanotubes arrays using silk fibroin coating</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Bacterial infection, wide inflammation, and osteoporosis are the most common factors in the failure of orthopedic implants. The present study aims to design an orthopedic implant based on Titania nanotubes (TiO2-NTs) which not only have a high biocompatibility but also are characterized by anti-bacterial property. In order to improve the osseointegration of the TiO2-NTs structures (110–120 nm in diameter, 40 μm in length), they were used to coat the Titania implant by electrochemical anodizing. Vancomycin, which is soluble in water, was loaded as a main clinical drug to control intensive infections caused by positive gram bacteria. For the first time, Silk Fibroin (SF) Nanofibers coating was used to control drug release by the implementation of electrospinning on the TiO2-NTs surface. In order to investigate the anti-bacterial activities, S. aureus bacterium culture test was used. The cell culture of MG63 was conducted for both coated and non-coated samples of TiO2-NTs. The results showed that the SF Nanofibers coating not only controls the drug being freely released from TiO2-NTs but also effects adhesion and development of osteoblast cells. In this regard, this coating inhibits biofilm formation and development, as well as bacteria colonization due to anti-bacterial drug release. Therefore, this system can be considered as a promising alternative for orthopedic implants, preventing bone infection, osteomyelitis, bone cancer treatment, and other orthopedic diseases.
[Display omitted]
•Preparation and coating of TiO2-NTs by electrochemical anodization method•Improved surface Wettability of TiO2-NTs studied by Contact Angle•Change in physicochemical surface properties of Titania nano-structures as a function of various diameters for drug loading•Study and Characterization of Surface Morphology by Atomic Force Microscopy•Coating of SF nanofibers on TiO2-NTs, by electrospinning technique•promoting osteoblast cell adhesion on the TiO2-NTs and SF nanofibers•TiO2-NTs implants could act as potential biocompatible drug carriers•Desirable and sustained release of Vancomycin from TiO2-NTs•All samples show antibacterial activity against Staphylococcus aureus•Results suggest a promising platform for biomedical applications</description><subject>Adhesion</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Biocompatibility</subject><subject>Biofilms</subject><subject>Biomedical materials</subject><subject>Bone cancer</subject><subject>Bone implants</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell culture</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coated Materials, Biocompatible - pharmacokinetics</subject><subject>Coating</subject><subject>Coatings</subject><subject>Colonization</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacokinetics</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Liberation</subject><subject>Electrochemistry</subject><subject>Fibroins - chemistry</subject><subject>Gram-negative bacteria</subject><subject>Humans</subject><subject>Infections</subject><subject>Materials science</subject><subject>Medical treatment</subject><subject>Microscopy, Atomic Force</subject><subject>Nanofibers</subject><subject>Nanotechnology</subject><subject>Nanotubes</subject><subject>Nanotubes - chemistry</subject><subject>Orthopaedic implants</subject><subject>Orthopedics</subject><subject>Osseointegration</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - drug effects</subject><subject>Osteomyelitis</subject><subject>Osteoporosis</subject><subject>Silk</subject><subject>Silk fibroin</subject><subject>Silk Fibroin Nanofibers</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Surface Properties</subject><subject>Surgical implants</subject><subject>Titania nanotubes</subject><subject>Titanium - chemistry</subject><subject>Titanium dioxide</subject><subject>Titanium implants</subject><subject>Transplants & implants</subject><subject>Vancomycin</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - pharmacokinetics</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVJaTZpv0APRZBLL97qj21Z0EtY2iQQyCU9C1kap9raUqqRA_n21bJpDz3kJHj6vcfMPEI-crbljPdf9tsFwW0F47oKWrXyDdnwQcmmKvyEbJgWQ9NqyU_JGeKesX6QSrwjp5LLVneSbch6GUsYQyrBIfV5faAZZrAI1KVYcprnEB-ojZ4mLJDG2WKh1v8EDCnSKaeF3odiY7A02pjKOgJSm7N9RrriwYth_kWnMOYUYg21pYrvydvJzggfXt5z8uP7t_vddXN7d3Wzu7xtnBza0qjW2d46Ja1qYRgBhAfFPcih15rXv6m3HMBD1yktLPedYForr6aOTV1d_Jx8PuY-5vR7BSxmCehgnm2EtKIRou9Uy4XsKnrxH7pPa451ukoNrJ5LS1EpcaRcTogZJvOYw2Lzs-HMHEoxe3MoxRxKMcdSqunTS_Q6LuD_Wf62UIGvRwDqLZ4CZIMuQHTgQwZXjE_htfw_6pmfkA</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Fathi, Mehdi</creator><creator>Akbari, Babak</creator><creator>Taheriazam, Afshin</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7175-3742</orcidid><orcidid>https://orcid.org/0000-0002-3764-6855</orcidid></search><sort><creationdate>201910</creationdate><title>Antibiotics drug release controlling and osteoblast adhesion from Titania nanotubes arrays using silk fibroin coating</title><author>Fathi, Mehdi ; Akbari, Babak ; Taheriazam, Afshin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-74ca6ac73a74e8bee2de71de386991ca6f6a1eede55792a1d520997d7f50f5493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adhesion</topic><topic>Anti-Bacterial Agents - 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chemistry</topic><topic>Orthopaedic implants</topic><topic>Orthopedics</topic><topic>Osseointegration</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - drug effects</topic><topic>Osteomyelitis</topic><topic>Osteoporosis</topic><topic>Silk</topic><topic>Silk fibroin</topic><topic>Silk Fibroin Nanofibers</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Surface Properties</topic><topic>Surgical implants</topic><topic>Titania nanotubes</topic><topic>Titanium - chemistry</topic><topic>Titanium dioxide</topic><topic>Titanium implants</topic><topic>Transplants & implants</topic><topic>Vancomycin</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - pharmacokinetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Fathi, Mehdi</creatorcontrib><creatorcontrib>Akbari, Babak</creatorcontrib><creatorcontrib>Taheriazam, Afshin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fathi, Mehdi</au><au>Akbari, Babak</au><au>Taheriazam, Afshin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotics drug release controlling and osteoblast adhesion from Titania nanotubes arrays using silk fibroin coating</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2019-10</date><risdate>2019</risdate><volume>103</volume><spage>109743</spage><epage>109743</epage><pages>109743-109743</pages><artnum>109743</artnum><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Bacterial infection, wide inflammation, and osteoporosis are the most common factors in the failure of orthopedic implants. The present study aims to design an orthopedic implant based on Titania nanotubes (TiO2-NTs) which not only have a high biocompatibility but also are characterized by anti-bacterial property. In order to improve the osseointegration of the TiO2-NTs structures (110–120 nm in diameter, 40 μm in length), they were used to coat the Titania implant by electrochemical anodizing. Vancomycin, which is soluble in water, was loaded as a main clinical drug to control intensive infections caused by positive gram bacteria. For the first time, Silk Fibroin (SF) Nanofibers coating was used to control drug release by the implementation of electrospinning on the TiO2-NTs surface. In order to investigate the anti-bacterial activities, S. aureus bacterium culture test was used. The cell culture of MG63 was conducted for both coated and non-coated samples of TiO2-NTs. The results showed that the SF Nanofibers coating not only controls the drug being freely released from TiO2-NTs but also effects adhesion and development of osteoblast cells. In this regard, this coating inhibits biofilm formation and development, as well as bacteria colonization due to anti-bacterial drug release. Therefore, this system can be considered as a promising alternative for orthopedic implants, preventing bone infection, osteomyelitis, bone cancer treatment, and other orthopedic diseases.
[Display omitted]
•Preparation and coating of TiO2-NTs by electrochemical anodization method•Improved surface Wettability of TiO2-NTs studied by Contact Angle•Change in physicochemical surface properties of Titania nano-structures as a function of various diameters for drug loading•Study and Characterization of Surface Morphology by Atomic Force Microscopy•Coating of SF nanofibers on TiO2-NTs, by electrospinning technique•promoting osteoblast cell adhesion on the TiO2-NTs and SF nanofibers•TiO2-NTs implants could act as potential biocompatible drug carriers•Desirable and sustained release of Vancomycin from TiO2-NTs•All samples show antibacterial activity against Staphylococcus aureus•Results suggest a promising platform for biomedical applications</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31349530</pmid><doi>10.1016/j.msec.2019.109743</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7175-3742</orcidid><orcidid>https://orcid.org/0000-0002-3764-6855</orcidid></addata></record> |
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| subjects | Adhesion Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Antibiotics Bacteria Bacterial infections Biocompatibility Biofilms Biomedical materials Bone cancer Bone implants Cell Adhesion - drug effects Cell culture Cell Line Cell Proliferation - drug effects Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacokinetics Coating Coatings Colonization Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug delivery Drug delivery systems Drug Liberation Electrochemistry Fibroins - chemistry Gram-negative bacteria Humans Infections Materials science Medical treatment Microscopy, Atomic Force Nanofibers Nanotechnology Nanotubes Nanotubes - chemistry Orthopaedic implants Orthopedics Osseointegration Osteoblasts - cytology Osteoblasts - drug effects Osteomyelitis Osteoporosis Silk Silk fibroin Silk Fibroin Nanofibers Staphylococcus aureus - drug effects Surface Properties Surgical implants Titania nanotubes Titanium - chemistry Titanium dioxide Titanium implants Transplants & implants Vancomycin Vancomycin - administration & dosage Vancomycin - pharmacokinetics |
| title | Antibiotics drug release controlling and osteoblast adhesion from Titania nanotubes arrays using silk fibroin coating |
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