A randomised, double-blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial

Preclinical studies suggest that type 2 hyperpolarization-activated cyclic nucleotide gated ion channels (HCN2) are necessary for neuropathic pain. This trial assessed the influence of ivabradine, a nonselective HCN channel blocker, on capsaicin-induced hyperalgesia and pain in healthy human subject...

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Veröffentlicht in:	Pain (Amsterdam) 2019-11, Vol.160 (11), p.2554-2565
Hauptverfasser:	Lee, Michael C., Bond, Simon, Wheeler, Daniel, Scholtes, Ingrid, Armstrong, Graham, McNaughton, Peter, Menon, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - therapeutic use Benzazepines - therapeutic use Calcium Channel Blockers - therapeutic use Double-Blind Method Heart Rate - drug effects Hyperalgesia - drug therapy Ivabradine - therapeutic use Neuralgia - drug therapy
Online-Zugang:	Volltext
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