Gastrectomy for invasive micropapillary carcinoma is associated with poorer disease-free and disease-specific survival
Background Invasive micropapillary carcinoma (IMPC) is a relatively rare subtype of gastric adenocarcinoma and has aggressive histopathologic characteristics, including lymphatic and vascular invasion. However, the associated long-term survival outcomes remain unclear. This study aimed to compare th...
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| Veröffentlicht in: | International journal of clinical oncology 2019-12, Vol.24 (12), p.1565-1573 |
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| creator | Kano, Mikihiro Hihara, Jun Kaneko, Mayumi Uemura, Kenichiro Ohge, Hiroki Sueda, Taijiro |
| description | Background
Invasive micropapillary carcinoma (IMPC) is a relatively rare subtype of gastric adenocarcinoma and has aggressive histopathologic characteristics, including lymphatic and vascular invasion. However, the associated long-term survival outcomes remain unclear. This study aimed to compare the clinicopathological characteristics and prognosis of gastric adenocarcinoma with and without IMPC using propensity score-matched (PSM) analysis.
Methods
Patients with gastric adenocarcinoma who underwent gastrectomy between 2006 and 2015 were included in the analysis. PSM analysis was performed to compensate for the background heterogeneity between the groups. The primary endpoint was disease-free survival (DFS) after gastrectomy, and the secondary endpoints were disease-specific survival (DSS) and recurrence pattern.
Results
Of 882 patients who underwent gastrectomy for gastric adenocarcinoma, with a follow-up duration greater than 36 months, 35 were diagnosed as having gastric adenocarcinoma with IMPC. After PSM, 70 patients, including 35 with IMPC and 35 without IMPC, were selected. Gastric adenocarcinoma with IMPC is characterized by lymphatic invasion (94% versus 69%,
p
= 0.012). Patients with IMPC had significantly poorer DFS than those without IMPC, with 3-year DFS rates of 62.2% and 93.4% (
p
= 0.003), respectively. Furthermore, a significant difference was also observed in DSS (
p
= 0.016); patients with IMPC more frequently developed liver metastasis (20%) than those without IMPC (3%,
p
= 0.006).
Conclusions
Resected gastric carcinoma with IMPC was associated with poorer DFS and DSS; furthermore, an increased rate of lymphatic invasion and liver metastasis was noted than in cases without IMPC. |
| doi_str_mv | 10.1007/s10147-019-01514-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2261970461</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1962203831</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-b930928a54da7dde58d763459c76dc7983a30f577c108ee7e1693d6009ce1d663</originalsourceid><addsrcrecordid>eNp9kUFvFiEQhomxsbX6BzwYopde1sKyMMvRNFpNmnhpz4TCrNJ8u6zM7tr-e7FfrYmJHggEnnmBeRh7JcU7KQSckhSyg0ZIW4eWXXP7hB3JTkEDAO3TuladbKxp9SF7TnQjhASj22fsUEnVggBxxLZzT0vBsOTxjg-58DRtntKGfEyh5NnPabfz5Y4HX0Ka8uh5Iu6Jckh-wch_pOUbn3MuWHhMhJ6wGQoi91N83KAZQxpS4LSWLW1-94IdDH5H-PJhPmZXHz9cnn1qLr6cfz57f9EErbulubZK2Lb3uoseYkTdRzCq0zaAiQFsr7wSgwYIUvSIgNJYFY0QNqCMxqhjdrLPnUv-viItbkwUsH5pwrySa1sjLYjOyIq-_Qu9yWuZ6utcq5SyPVjoKvXmn5RQVmnTQ4XaPVQ7SFRwcHNJY-2ik8L9Uuf26lxV5-7Vudta9Poheb0eMT6W_HZVAbUHqB5NX7H8ufo_sT8BI9ylaw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>203935687</pqid></control><display><type>article</type><title>Gastrectomy for invasive micropapillary carcinoma is associated with poorer disease-free and disease-specific survival</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kano, Mikihiro ; Hihara, Jun ; Kaneko, Mayumi ; Uemura, Kenichiro ; Ohge, Hiroki ; Sueda, Taijiro</creator><creatorcontrib>Kano, Mikihiro ; Hihara, Jun ; Kaneko, Mayumi ; Uemura, Kenichiro ; Ohge, Hiroki ; Sueda, Taijiro</creatorcontrib><description>Background
Invasive micropapillary carcinoma (IMPC) is a relatively rare subtype of gastric adenocarcinoma and has aggressive histopathologic characteristics, including lymphatic and vascular invasion. However, the associated long-term survival outcomes remain unclear. This study aimed to compare the clinicopathological characteristics and prognosis of gastric adenocarcinoma with and without IMPC using propensity score-matched (PSM) analysis.
Methods
Patients with gastric adenocarcinoma who underwent gastrectomy between 2006 and 2015 were included in the analysis. PSM analysis was performed to compensate for the background heterogeneity between the groups. The primary endpoint was disease-free survival (DFS) after gastrectomy, and the secondary endpoints were disease-specific survival (DSS) and recurrence pattern.
Results
Of 882 patients who underwent gastrectomy for gastric adenocarcinoma, with a follow-up duration greater than 36 months, 35 were diagnosed as having gastric adenocarcinoma with IMPC. After PSM, 70 patients, including 35 with IMPC and 35 without IMPC, were selected. Gastric adenocarcinoma with IMPC is characterized by lymphatic invasion (94% versus 69%,
p
= 0.012). Patients with IMPC had significantly poorer DFS than those without IMPC, with 3-year DFS rates of 62.2% and 93.4% (
p
= 0.003), respectively. Furthermore, a significant difference was also observed in DSS (
p
= 0.016); patients with IMPC more frequently developed liver metastasis (20%) than those without IMPC (3%,
p
= 0.006).
Conclusions
Resected gastric carcinoma with IMPC was associated with poorer DFS and DSS; furthermore, an increased rate of lymphatic invasion and liver metastasis was noted than in cases without IMPC.</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-019-01514-x</identifier><identifier>PMID: 31327070</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adenocarcinoma ; Adenocarcinoma, Papillary - mortality ; Adenocarcinoma, Papillary - pathology ; Adenocarcinoma, Papillary - surgery ; Adult ; Aged ; Aged, 80 and over ; Cancer Research ; Chemotherapy ; Disease-Free Survival ; Female ; Gastrectomy ; Gastric cancer ; Humans ; Invasiveness ; Leukemia ; Liver ; Liver Neoplasms - secondary ; Lymphatic Metastasis - pathology ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Middle Aged ; Neoplasm Recurrence, Local ; Oncology ; Original Article ; Prognosis ; Propensity Score ; Prostate cancer ; Radiation therapy ; Retrospective Studies ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgical Oncology ; Survival</subject><ispartof>International journal of clinical oncology, 2019-12, Vol.24 (12), p.1565-1573</ispartof><rights>Japan Society of Clinical Oncology 2019</rights><rights>International Journal of Clinical Oncology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-b930928a54da7dde58d763459c76dc7983a30f577c108ee7e1693d6009ce1d663</citedby><cites>FETCH-LOGICAL-c554t-b930928a54da7dde58d763459c76dc7983a30f577c108ee7e1693d6009ce1d663</cites><orcidid>0000-0003-2108-2028</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10147-019-01514-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10147-019-01514-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31327070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kano, Mikihiro</creatorcontrib><creatorcontrib>Hihara, Jun</creatorcontrib><creatorcontrib>Kaneko, Mayumi</creatorcontrib><creatorcontrib>Uemura, Kenichiro</creatorcontrib><creatorcontrib>Ohge, Hiroki</creatorcontrib><creatorcontrib>Sueda, Taijiro</creatorcontrib><title>Gastrectomy for invasive micropapillary carcinoma is associated with poorer disease-free and disease-specific survival</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><addtitle>Int J Clin Oncol</addtitle><description>Background
Invasive micropapillary carcinoma (IMPC) is a relatively rare subtype of gastric adenocarcinoma and has aggressive histopathologic characteristics, including lymphatic and vascular invasion. However, the associated long-term survival outcomes remain unclear. This study aimed to compare the clinicopathological characteristics and prognosis of gastric adenocarcinoma with and without IMPC using propensity score-matched (PSM) analysis.
Methods
Patients with gastric adenocarcinoma who underwent gastrectomy between 2006 and 2015 were included in the analysis. PSM analysis was performed to compensate for the background heterogeneity between the groups. The primary endpoint was disease-free survival (DFS) after gastrectomy, and the secondary endpoints were disease-specific survival (DSS) and recurrence pattern.
Results
Of 882 patients who underwent gastrectomy for gastric adenocarcinoma, with a follow-up duration greater than 36 months, 35 were diagnosed as having gastric adenocarcinoma with IMPC. After PSM, 70 patients, including 35 with IMPC and 35 without IMPC, were selected. Gastric adenocarcinoma with IMPC is characterized by lymphatic invasion (94% versus 69%,
p
= 0.012). Patients with IMPC had significantly poorer DFS than those without IMPC, with 3-year DFS rates of 62.2% and 93.4% (
p
= 0.003), respectively. Furthermore, a significant difference was also observed in DSS (
p
= 0.016); patients with IMPC more frequently developed liver metastasis (20%) than those without IMPC (3%,
p
= 0.006).
Conclusions
Resected gastric carcinoma with IMPC was associated with poorer DFS and DSS; furthermore, an increased rate of lymphatic invasion and liver metastasis was noted than in cases without IMPC.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma, Papillary - mortality</subject><subject>Adenocarcinoma, Papillary - pathology</subject><subject>Adenocarcinoma, Papillary - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer Research</subject><subject>Chemotherapy</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Leukemia</subject><subject>Liver</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Propensity Score</subject><subject>Prostate cancer</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUFvFiEQhomxsbX6BzwYopde1sKyMMvRNFpNmnhpz4TCrNJ8u6zM7tr-e7FfrYmJHggEnnmBeRh7JcU7KQSckhSyg0ZIW4eWXXP7hB3JTkEDAO3TuladbKxp9SF7TnQjhASj22fsUEnVggBxxLZzT0vBsOTxjg-58DRtntKGfEyh5NnPabfz5Y4HX0Ka8uh5Iu6Jckh-wch_pOUbn3MuWHhMhJ6wGQoi91N83KAZQxpS4LSWLW1-94IdDH5H-PJhPmZXHz9cnn1qLr6cfz57f9EErbulubZK2Lb3uoseYkTdRzCq0zaAiQFsr7wSgwYIUvSIgNJYFY0QNqCMxqhjdrLPnUv-viItbkwUsH5pwrySa1sjLYjOyIq-_Qu9yWuZ6utcq5SyPVjoKvXmn5RQVmnTQ4XaPVQ7SFRwcHNJY-2ik8L9Uuf26lxV5-7Vudta9Poheb0eMT6W_HZVAbUHqB5NX7H8ufo_sT8BI9ylaw</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Kano, Mikihiro</creator><creator>Hihara, Jun</creator><creator>Kaneko, Mayumi</creator><creator>Uemura, Kenichiro</creator><creator>Ohge, Hiroki</creator><creator>Sueda, Taijiro</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2108-2028</orcidid></search><sort><creationdate>20191201</creationdate><title>Gastrectomy for invasive micropapillary carcinoma is associated with poorer disease-free and disease-specific survival</title><author>Kano, Mikihiro ; Hihara, Jun ; Kaneko, Mayumi ; Uemura, Kenichiro ; Ohge, Hiroki ; Sueda, Taijiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-b930928a54da7dde58d763459c76dc7983a30f577c108ee7e1693d6009ce1d663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma, Papillary - mortality</topic><topic>Adenocarcinoma, Papillary - pathology</topic><topic>Adenocarcinoma, Papillary - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer Research</topic><topic>Chemotherapy</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>Leukemia</topic><topic>Liver</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Propensity Score</topic><topic>Prostate cancer</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kano, Mikihiro</creatorcontrib><creatorcontrib>Hihara, Jun</creatorcontrib><creatorcontrib>Kaneko, Mayumi</creatorcontrib><creatorcontrib>Uemura, Kenichiro</creatorcontrib><creatorcontrib>Ohge, Hiroki</creatorcontrib><creatorcontrib>Sueda, Taijiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kano, Mikihiro</au><au>Hihara, Jun</au><au>Kaneko, Mayumi</au><au>Uemura, Kenichiro</au><au>Ohge, Hiroki</au><au>Sueda, Taijiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrectomy for invasive micropapillary carcinoma is associated with poorer disease-free and disease-specific survival</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><addtitle>Int J Clin Oncol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>24</volume><issue>12</issue><spage>1565</spage><epage>1573</epage><pages>1565-1573</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>Background
Invasive micropapillary carcinoma (IMPC) is a relatively rare subtype of gastric adenocarcinoma and has aggressive histopathologic characteristics, including lymphatic and vascular invasion. However, the associated long-term survival outcomes remain unclear. This study aimed to compare the clinicopathological characteristics and prognosis of gastric adenocarcinoma with and without IMPC using propensity score-matched (PSM) analysis.
Methods
Patients with gastric adenocarcinoma who underwent gastrectomy between 2006 and 2015 were included in the analysis. PSM analysis was performed to compensate for the background heterogeneity between the groups. The primary endpoint was disease-free survival (DFS) after gastrectomy, and the secondary endpoints were disease-specific survival (DSS) and recurrence pattern.
Results
Of 882 patients who underwent gastrectomy for gastric adenocarcinoma, with a follow-up duration greater than 36 months, 35 were diagnosed as having gastric adenocarcinoma with IMPC. After PSM, 70 patients, including 35 with IMPC and 35 without IMPC, were selected. Gastric adenocarcinoma with IMPC is characterized by lymphatic invasion (94% versus 69%,
p
= 0.012). Patients with IMPC had significantly poorer DFS than those without IMPC, with 3-year DFS rates of 62.2% and 93.4% (
p
= 0.003), respectively. Furthermore, a significant difference was also observed in DSS (
p
= 0.016); patients with IMPC more frequently developed liver metastasis (20%) than those without IMPC (3%,
p
= 0.006).
Conclusions
Resected gastric carcinoma with IMPC was associated with poorer DFS and DSS; furthermore, an increased rate of lymphatic invasion and liver metastasis was noted than in cases without IMPC.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>31327070</pmid><doi>10.1007/s10147-019-01514-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2108-2028</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of clinical oncology, 2019-12, Vol.24 (12), p.1565-1573 |
| issn | 1341-9625 1437-7772 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenocarcinoma Adenocarcinoma, Papillary - mortality Adenocarcinoma, Papillary - pathology Adenocarcinoma, Papillary - surgery Adult Aged Aged, 80 and over Cancer Research Chemotherapy Disease-Free Survival Female Gastrectomy Gastric cancer Humans Invasiveness Leukemia Liver Liver Neoplasms - secondary Lymphatic Metastasis - pathology Male Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Middle Aged Neoplasm Recurrence, Local Oncology Original Article Prognosis Propensity Score Prostate cancer Radiation therapy Retrospective Studies Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgical Oncology Survival |
| title | Gastrectomy for invasive micropapillary carcinoma is associated with poorer disease-free and disease-specific survival |
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