High levels of ANXA2 are characteristic of malignant salivary gland tumors
Objective Malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT. Methods For screening, p...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2019-11, Vol.48 (10), p.929-934 |
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| creator | Cardoso, Claudio Marcelo de Jesus, Sabrina Ferreira de Souza, Marcela Gonçalves Queiroz, Lorena dos Reis Pereira Santos, Eloa Mangabeira Santos, Erivelton Pereira Oliveira, Luis Paulo Cordeiro Santos, Cristiane Karine Santos, Sérgio Henrique Sousa Paula, Alfredo Maurício Batista Farias, Lucyana Conceição Guimaraes, Andre Luiz Sena |
| description | Objective
Malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT.
Methods
For screening, proteomic analysis comparing MSGT with pleomorphic adenoma (PA) and salivary gland was performed. The MSGT‐associated protein which presented in the higher number in the Gene Expression Omnibus (GEO) database was selected. To validate the data, immunohistochemistry (IHC) was performed in 14 patients with PA, 22 patients with MSGT, and 14 controls.
Results
16 proteins were associated with MSGT. ANXA2 was the primary protein, according to GEO database analyses. ANXA2 was most expressed in the cell membrane. However, some ANXA2 staining was also observed in the cytoplasm and nucleus. ANXA2 was highly expressed in MSGT in comparison with control. Also, ANXA2 has a higher expression in adenocarcinoma not otherwise specified (ANOS) and myoepithelial carcinoma (MC) in comparison with PA.
Conclusion
In conclusion, this study demonstrated that MSGT presented higher levels of ANXA2 in comparison with normal salivary glands. Also, ANXA2 might be interesting as a molecular marker of ANOS and MS. |
| doi_str_mv | 10.1111/jop.12932 |
| format | Article |
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Malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT.
Methods
For screening, proteomic analysis comparing MSGT with pleomorphic adenoma (PA) and salivary gland was performed. The MSGT‐associated protein which presented in the higher number in the Gene Expression Omnibus (GEO) database was selected. To validate the data, immunohistochemistry (IHC) was performed in 14 patients with PA, 22 patients with MSGT, and 14 controls.
Results
16 proteins were associated with MSGT. ANXA2 was the primary protein, according to GEO database analyses. ANXA2 was most expressed in the cell membrane. However, some ANXA2 staining was also observed in the cytoplasm and nucleus. ANXA2 was highly expressed in MSGT in comparison with control. Also, ANXA2 has a higher expression in adenocarcinoma not otherwise specified (ANOS) and myoepithelial carcinoma (MC) in comparison with PA.
Conclusion
In conclusion, this study demonstrated that MSGT presented higher levels of ANXA2 in comparison with normal salivary glands. Also, ANXA2 might be interesting as a molecular marker of ANOS and MS.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.12932</identifier><identifier>PMID: 31325182</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma ; Adenoma ; Adenoma, Pleomorphic - metabolism ; Adenoma, Pleomorphic - pathology ; Annexin A2 - metabolism ; Biomarkers, Tumor - metabolism ; Carcinoma, Adenoid Cystic - metabolism ; Carcinoma, Adenoid Cystic - pathology ; Carcinoma, Mucoepidermoid - metabolism ; Carcinoma, Mucoepidermoid - pathology ; Case-Control Studies ; Cell membranes ; Cytoplasm ; Dentistry ; Gene expression ; gland ; Humans ; Immunohistochemistry ; malignancy ; metastasis ; neoplasm ; Oral cancer ; Proteome ; Proteomics ; Salivary gland ; Salivary Gland Neoplasms - metabolism ; Salivary Gland Neoplasms - pathology ; Tumors</subject><ispartof>Journal of oral pathology & medicine, 2019-11, Vol.48 (10), p.929-934</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-337b4351c0f4649fadc8dada039d962338f88dafb8ebd2bc23acce1de0c242323</citedby><cites>FETCH-LOGICAL-c3532-337b4351c0f4649fadc8dada039d962338f88dafb8ebd2bc23acce1de0c242323</cites><orcidid>0000-0002-3162-3206 ; 0000-0002-5379-361X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.12932$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.12932$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31325182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cardoso, Claudio Marcelo</creatorcontrib><creatorcontrib>de Jesus, Sabrina Ferreira</creatorcontrib><creatorcontrib>de Souza, Marcela Gonçalves</creatorcontrib><creatorcontrib>Queiroz, Lorena dos Reis Pereira</creatorcontrib><creatorcontrib>Santos, Eloa Mangabeira</creatorcontrib><creatorcontrib>Santos, Erivelton Pereira</creatorcontrib><creatorcontrib>Oliveira, Luis Paulo</creatorcontrib><creatorcontrib>Cordeiro Santos, Cristiane Karine</creatorcontrib><creatorcontrib>Santos, Sérgio Henrique Sousa</creatorcontrib><creatorcontrib>Paula, Alfredo Maurício Batista</creatorcontrib><creatorcontrib>Farias, Lucyana Conceição</creatorcontrib><creatorcontrib>Guimaraes, Andre Luiz Sena</creatorcontrib><title>High levels of ANXA2 are characteristic of malignant salivary gland tumors</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Objective
Malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT.
Methods
For screening, proteomic analysis comparing MSGT with pleomorphic adenoma (PA) and salivary gland was performed. The MSGT‐associated protein which presented in the higher number in the Gene Expression Omnibus (GEO) database was selected. To validate the data, immunohistochemistry (IHC) was performed in 14 patients with PA, 22 patients with MSGT, and 14 controls.
Results
16 proteins were associated with MSGT. ANXA2 was the primary protein, according to GEO database analyses. ANXA2 was most expressed in the cell membrane. However, some ANXA2 staining was also observed in the cytoplasm and nucleus. ANXA2 was highly expressed in MSGT in comparison with control. Also, ANXA2 has a higher expression in adenocarcinoma not otherwise specified (ANOS) and myoepithelial carcinoma (MC) in comparison with PA.
Conclusion
In conclusion, this study demonstrated that MSGT presented higher levels of ANXA2 in comparison with normal salivary glands. Also, ANXA2 might be interesting as a molecular marker of ANOS and MS.</description><subject>Adenocarcinoma</subject><subject>Adenoma</subject><subject>Adenoma, Pleomorphic - metabolism</subject><subject>Adenoma, Pleomorphic - pathology</subject><subject>Annexin A2 - metabolism</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Adenoid Cystic - metabolism</subject><subject>Carcinoma, Adenoid Cystic - pathology</subject><subject>Carcinoma, Mucoepidermoid - metabolism</subject><subject>Carcinoma, Mucoepidermoid - pathology</subject><subject>Case-Control Studies</subject><subject>Cell membranes</subject><subject>Cytoplasm</subject><subject>Dentistry</subject><subject>Gene expression</subject><subject>gland</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>malignancy</subject><subject>metastasis</subject><subject>neoplasm</subject><subject>Oral cancer</subject><subject>Proteome</subject><subject>Proteomics</subject><subject>Salivary gland</subject><subject>Salivary Gland Neoplasms - metabolism</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Tumors</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwzAMhiMEYmNw4A-gSFzg0C2xu649ThMwJsQ4gMQtStN069QvknZo_56MDg5I-GLLfvzKfgm55GzIXYw2VT3kECEckT4PGPPYhPvHpM8i5nsw5tAjZ9ZuGOMT9Pkp6SFH1w6hTxbzbLWmud7q3NIqpdPn9ylQaTRVa2mkarTJbJOp_ayQebYqZdlQ66qtNDu6ymWZ0KYtKmPPyUkqc6svDnlA3u7vXmdz72n58DibPnkKxwge4iT2ccwVS_3Aj1KZqDCRiWQYJVEAiGEaukYahzpOIFaAUinNE80U-ICAA3LT6dam-mi1bUSRWaVzd4quWisAAh4FEWN79PoPuqlaU7rrBCAHh_kBOuq2o5SprDU6FbXJCvee4EzsDXZbtfg22LFXB8U2LnTyS_446oBRB3xmud79ryQWy5dO8gtm-4N8</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Cardoso, Claudio Marcelo</creator><creator>de Jesus, Sabrina Ferreira</creator><creator>de Souza, Marcela Gonçalves</creator><creator>Queiroz, Lorena dos Reis Pereira</creator><creator>Santos, Eloa Mangabeira</creator><creator>Santos, Erivelton Pereira</creator><creator>Oliveira, Luis Paulo</creator><creator>Cordeiro Santos, Cristiane Karine</creator><creator>Santos, Sérgio Henrique Sousa</creator><creator>Paula, Alfredo Maurício Batista</creator><creator>Farias, Lucyana Conceição</creator><creator>Guimaraes, Andre Luiz Sena</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3162-3206</orcidid><orcidid>https://orcid.org/0000-0002-5379-361X</orcidid></search><sort><creationdate>201911</creationdate><title>High levels of ANXA2 are characteristic of malignant salivary gland tumors</title><author>Cardoso, Claudio Marcelo ; de Jesus, Sabrina Ferreira ; de Souza, Marcela Gonçalves ; Queiroz, Lorena dos Reis Pereira ; Santos, Eloa Mangabeira ; Santos, Erivelton Pereira ; Oliveira, Luis Paulo ; Cordeiro Santos, Cristiane Karine ; Santos, Sérgio Henrique Sousa ; Paula, Alfredo Maurício Batista ; Farias, Lucyana Conceição ; Guimaraes, Andre Luiz Sena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-337b4351c0f4649fadc8dada039d962338f88dafb8ebd2bc23acce1de0c242323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma</topic><topic>Adenoma</topic><topic>Adenoma, Pleomorphic - metabolism</topic><topic>Adenoma, Pleomorphic - pathology</topic><topic>Annexin A2 - metabolism</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Adenoid Cystic - metabolism</topic><topic>Carcinoma, Adenoid Cystic - pathology</topic><topic>Carcinoma, Mucoepidermoid - metabolism</topic><topic>Carcinoma, Mucoepidermoid - pathology</topic><topic>Case-Control Studies</topic><topic>Cell membranes</topic><topic>Cytoplasm</topic><topic>Dentistry</topic><topic>Gene expression</topic><topic>gland</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>malignancy</topic><topic>metastasis</topic><topic>neoplasm</topic><topic>Oral cancer</topic><topic>Proteome</topic><topic>Proteomics</topic><topic>Salivary gland</topic><topic>Salivary Gland Neoplasms - metabolism</topic><topic>Salivary Gland Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardoso, Claudio Marcelo</creatorcontrib><creatorcontrib>de Jesus, Sabrina Ferreira</creatorcontrib><creatorcontrib>de Souza, Marcela Gonçalves</creatorcontrib><creatorcontrib>Queiroz, Lorena dos Reis Pereira</creatorcontrib><creatorcontrib>Santos, Eloa Mangabeira</creatorcontrib><creatorcontrib>Santos, Erivelton Pereira</creatorcontrib><creatorcontrib>Oliveira, Luis Paulo</creatorcontrib><creatorcontrib>Cordeiro Santos, Cristiane Karine</creatorcontrib><creatorcontrib>Santos, Sérgio Henrique Sousa</creatorcontrib><creatorcontrib>Paula, Alfredo Maurício Batista</creatorcontrib><creatorcontrib>Farias, Lucyana Conceição</creatorcontrib><creatorcontrib>Guimaraes, Andre Luiz Sena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cardoso, Claudio Marcelo</au><au>de Jesus, Sabrina Ferreira</au><au>de Souza, Marcela Gonçalves</au><au>Queiroz, Lorena dos Reis Pereira</au><au>Santos, Eloa Mangabeira</au><au>Santos, Erivelton Pereira</au><au>Oliveira, Luis Paulo</au><au>Cordeiro Santos, Cristiane Karine</au><au>Santos, Sérgio Henrique Sousa</au><au>Paula, Alfredo Maurício Batista</au><au>Farias, Lucyana Conceição</au><au>Guimaraes, Andre Luiz Sena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High levels of ANXA2 are characteristic of malignant salivary gland tumors</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2019-11</date><risdate>2019</risdate><volume>48</volume><issue>10</issue><spage>929</spage><epage>934</epage><pages>929-934</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Objective
Malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT.
Methods
For screening, proteomic analysis comparing MSGT with pleomorphic adenoma (PA) and salivary gland was performed. The MSGT‐associated protein which presented in the higher number in the Gene Expression Omnibus (GEO) database was selected. To validate the data, immunohistochemistry (IHC) was performed in 14 patients with PA, 22 patients with MSGT, and 14 controls.
Results
16 proteins were associated with MSGT. ANXA2 was the primary protein, according to GEO database analyses. ANXA2 was most expressed in the cell membrane. However, some ANXA2 staining was also observed in the cytoplasm and nucleus. ANXA2 was highly expressed in MSGT in comparison with control. Also, ANXA2 has a higher expression in adenocarcinoma not otherwise specified (ANOS) and myoepithelial carcinoma (MC) in comparison with PA.
Conclusion
In conclusion, this study demonstrated that MSGT presented higher levels of ANXA2 in comparison with normal salivary glands. Also, ANXA2 might be interesting as a molecular marker of ANOS and MS.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31325182</pmid><doi>10.1111/jop.12932</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3162-3206</orcidid><orcidid>https://orcid.org/0000-0002-5379-361X</orcidid></addata></record> |
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| subjects | Adenocarcinoma Adenoma Adenoma, Pleomorphic - metabolism Adenoma, Pleomorphic - pathology Annexin A2 - metabolism Biomarkers, Tumor - metabolism Carcinoma, Adenoid Cystic - metabolism Carcinoma, Adenoid Cystic - pathology Carcinoma, Mucoepidermoid - metabolism Carcinoma, Mucoepidermoid - pathology Case-Control Studies Cell membranes Cytoplasm Dentistry Gene expression gland Humans Immunohistochemistry malignancy metastasis neoplasm Oral cancer Proteome Proteomics Salivary gland Salivary Gland Neoplasms - metabolism Salivary Gland Neoplasms - pathology Tumors |
| title | High levels of ANXA2 are characteristic of malignant salivary gland tumors |
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