Non-contrast MRI for breast screening: preliminary study on detectability of benign and malignant lesions in women with dense breasts
Purpose The importance of breast cancer screening has long been known. Unfortunately, there is no imaging modality for screening women with dense breasts that is both sensitive and without concerns regarding potential side effects. The purpose of this study is to explore the possibility of combined...
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| Veröffentlicht in: | Breast cancer research and treatment 2019-10, Vol.177 (3), p.629-639 |
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| creator | Bu, Yangyang Xia, Jun Joseph, Bobby Zhao, Xianjing Xu, Maosheng Yu, Yingxing Qi, Shouliang Shah, Kamran A. Wang, Shiwei Hu, Jiani |
| description | Purpose
The importance of breast cancer screening has long been known. Unfortunately, there is no imaging modality for screening women with dense breasts that is both sensitive and without concerns regarding potential side effects. The purpose of this study is to explore the possibility of combined diffusion-weighted imaging and turbo inversion recovery magnitude MRI (DWI + TIRM) to overcome the difficulty of detection sensitivity and safety.
Methods
One hundred and seventy-six breast lesions from 166 women with dense breasts were retrospectively evaluated. The lesion visibility, area under the curve (AUC), sensitivity and specificity of cancer detection by MG, DWI + TIRM, and clinical MRI were evaluated and compared. MG plus clinical MRI served as the gold standard for lesion detection and pathology served as the gold standard for cancer detection.
Results
Lesion visibility of DWI + TIRM (96.6%) was significantly superior to MG (67.6%) in women with dense breasts (
p
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| doi_str_mv | 10.1007/s10549-019-05342-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2261967638</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A599557264</galeid><sourcerecordid>A599557264</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-e836f8d345e746605400305cbf1f20511eb47349ed1b82282671a125044353393</originalsourceid><addsrcrecordid>eNp9kl9r1TAYxoMobk6_gBcSEMSbzvxP690Y_hlMBdHrkLZvz8lIk2OSMvYB_N6mnqNzIlLSpunveZPn7YPQU0pOKSH6VaZEiq4htA7JBWvkPXRMpeaNZlTfR8eEKt2olqgj9CjnK0JIp0n3EB1xypkkWhyj7x9jaIYYSrK54A-fL_AUE-4TrK95SADBhc1rvEvg3eyCTTc4l2W8wTHgEQoMxfbOu1IXJtxXehOwDSOera9TGwr2kF0MGbuAr-MM9e7KtmpDhsNG-TF6MFmf4cnheYK-vn3z5fx9c_np3cX52WUzCM1LAy1XUztyIUELpap7QjiRQz_RiRFJKfSVEx2MtG8Za5nS1NLqVAguOe_4CXq5r7tL8dsCuZjZ5QG8twHikg1jinZKK95W9Plf6FVcUqinWynCWtpJcUttrAfjwhRrI4e1qDmTXSelZmqlTv9B1WuE2dXmw-Tq-h3Biz8EW7C-bHP0S1kbeRdke3BIMecEk9klN9efZCgxa0jMPiSmhsT8DImRVfTsYG3pZxh_S36logJ8D-T6KWwg3Xr_T9kfZ5zEdA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2260281954</pqid></control><display><type>article</type><title>Non-contrast MRI for breast screening: preliminary study on detectability of benign and malignant lesions in women with dense breasts</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bu, Yangyang ; Xia, Jun ; Joseph, Bobby ; Zhao, Xianjing ; Xu, Maosheng ; Yu, Yingxing ; Qi, Shouliang ; Shah, Kamran A. ; Wang, Shiwei ; Hu, Jiani</creator><creatorcontrib>Bu, Yangyang ; Xia, Jun ; Joseph, Bobby ; Zhao, Xianjing ; Xu, Maosheng ; Yu, Yingxing ; Qi, Shouliang ; Shah, Kamran A. ; Wang, Shiwei ; Hu, Jiani</creatorcontrib><description>Purpose
The importance of breast cancer screening has long been known. Unfortunately, there is no imaging modality for screening women with dense breasts that is both sensitive and without concerns regarding potential side effects. The purpose of this study is to explore the possibility of combined diffusion-weighted imaging and turbo inversion recovery magnitude MRI (DWI + TIRM) to overcome the difficulty of detection sensitivity and safety.
Methods
One hundred and seventy-six breast lesions from 166 women with dense breasts were retrospectively evaluated. The lesion visibility, area under the curve (AUC), sensitivity and specificity of cancer detection by MG, DWI + TIRM, and clinical MRI were evaluated and compared. MG plus clinical MRI served as the gold standard for lesion detection and pathology served as the gold standard for cancer detection.
Results
Lesion visibility of DWI + TIRM (96.6%) was significantly superior to MG (67.6%) in women with dense breasts (
p
< 0.001). There was no significant difference compared with clinical MRI. DWI + TIRM showed higher accuracy (AUC = 0.935) and sensitivity (93.68%) for breast cancer detection than MG (AUC = 0.783, sensitivity = 46.32%), but was comparable to clinical MRI (AUC = 0.944, sensitivity = 93.68%). The specificity of DWI + TIRM (83.95%) was lower than MG (98.77%), but higher than clinical MRI (77.78%).
Conclusions
DWI combined with TIRM could be a safe, sensitive, and practical alternative for screening women with dense breasts.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-019-05342-5</identifier><identifier>PMID: 31325074</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Breast cancer ; Breast Density ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - epidemiology ; Cancer ; Cancer research ; Cancer screening ; Diagnosis ; Drunk driving ; Female ; Humans ; Magnetic Resonance Imaging ; Mammary Glands, Human - diagnostic imaging ; Mammary Glands, Human - pathology ; Mammography ; Mass Screening ; Medical imaging equipment ; Medical screening ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Grading ; Oncology ; Preclinical Study ; Retrospective Studies ; ROC Curve ; Sensitivity and Specificity ; Tomography ; Women ; Young Adult</subject><ispartof>Breast cancer research and treatment, 2019-10, Vol.177 (3), p.629-639</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019. corrected publication 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Breast Cancer Research and Treatment is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-e836f8d345e746605400305cbf1f20511eb47349ed1b82282671a125044353393</citedby><cites>FETCH-LOGICAL-c473t-e836f8d345e746605400305cbf1f20511eb47349ed1b82282671a125044353393</cites><orcidid>0000-0002-2928-3169</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-019-05342-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-019-05342-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31325074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bu, Yangyang</creatorcontrib><creatorcontrib>Xia, Jun</creatorcontrib><creatorcontrib>Joseph, Bobby</creatorcontrib><creatorcontrib>Zhao, Xianjing</creatorcontrib><creatorcontrib>Xu, Maosheng</creatorcontrib><creatorcontrib>Yu, Yingxing</creatorcontrib><creatorcontrib>Qi, Shouliang</creatorcontrib><creatorcontrib>Shah, Kamran A.</creatorcontrib><creatorcontrib>Wang, Shiwei</creatorcontrib><creatorcontrib>Hu, Jiani</creatorcontrib><title>Non-contrast MRI for breast screening: preliminary study on detectability of benign and malignant lesions in women with dense breasts</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
The importance of breast cancer screening has long been known. Unfortunately, there is no imaging modality for screening women with dense breasts that is both sensitive and without concerns regarding potential side effects. The purpose of this study is to explore the possibility of combined diffusion-weighted imaging and turbo inversion recovery magnitude MRI (DWI + TIRM) to overcome the difficulty of detection sensitivity and safety.
Methods
One hundred and seventy-six breast lesions from 166 women with dense breasts were retrospectively evaluated. The lesion visibility, area under the curve (AUC), sensitivity and specificity of cancer detection by MG, DWI + TIRM, and clinical MRI were evaluated and compared. MG plus clinical MRI served as the gold standard for lesion detection and pathology served as the gold standard for cancer detection.
Results
Lesion visibility of DWI + TIRM (96.6%) was significantly superior to MG (67.6%) in women with dense breasts (
p
< 0.001). There was no significant difference compared with clinical MRI. DWI + TIRM showed higher accuracy (AUC = 0.935) and sensitivity (93.68%) for breast cancer detection than MG (AUC = 0.783, sensitivity = 46.32%), but was comparable to clinical MRI (AUC = 0.944, sensitivity = 93.68%). The specificity of DWI + TIRM (83.95%) was lower than MG (98.77%), but higher than clinical MRI (77.78%).
Conclusions
DWI combined with TIRM could be a safe, sensitive, and practical alternative for screening women with dense breasts.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Area Under Curve</subject><subject>Breast cancer</subject><subject>Breast Density</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer screening</subject><subject>Diagnosis</subject><subject>Drunk driving</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mammary Glands, Human - diagnostic imaging</subject><subject>Mammary Glands, Human - pathology</subject><subject>Mammography</subject><subject>Mass Screening</subject><subject>Medical imaging equipment</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Oncology</subject><subject>Preclinical Study</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Tomography</subject><subject>Women</subject><subject>Young Adult</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kl9r1TAYxoMobk6_gBcSEMSbzvxP690Y_hlMBdHrkLZvz8lIk2OSMvYB_N6mnqNzIlLSpunveZPn7YPQU0pOKSH6VaZEiq4htA7JBWvkPXRMpeaNZlTfR8eEKt2olqgj9CjnK0JIp0n3EB1xypkkWhyj7x9jaIYYSrK54A-fL_AUE-4TrK95SADBhc1rvEvg3eyCTTc4l2W8wTHgEQoMxfbOu1IXJtxXehOwDSOera9TGwr2kF0MGbuAr-MM9e7KtmpDhsNG-TF6MFmf4cnheYK-vn3z5fx9c_np3cX52WUzCM1LAy1XUztyIUELpap7QjiRQz_RiRFJKfSVEx2MtG8Za5nS1NLqVAguOe_4CXq5r7tL8dsCuZjZ5QG8twHikg1jinZKK95W9Plf6FVcUqinWynCWtpJcUttrAfjwhRrI4e1qDmTXSelZmqlTv9B1WuE2dXmw-Tq-h3Biz8EW7C-bHP0S1kbeRdke3BIMecEk9klN9efZCgxa0jMPiSmhsT8DImRVfTsYG3pZxh_S36logJ8D-T6KWwg3Xr_T9kfZ5zEdA</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Bu, Yangyang</creator><creator>Xia, Jun</creator><creator>Joseph, Bobby</creator><creator>Zhao, Xianjing</creator><creator>Xu, Maosheng</creator><creator>Yu, Yingxing</creator><creator>Qi, Shouliang</creator><creator>Shah, Kamran A.</creator><creator>Wang, Shiwei</creator><creator>Hu, Jiani</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2928-3169</orcidid></search><sort><creationdate>20191001</creationdate><title>Non-contrast MRI for breast screening: preliminary study on detectability of benign and malignant lesions in women with dense breasts</title><author>Bu, Yangyang ; Xia, Jun ; Joseph, Bobby ; Zhao, Xianjing ; Xu, Maosheng ; Yu, Yingxing ; Qi, Shouliang ; Shah, Kamran A. ; Wang, Shiwei ; Hu, Jiani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-e836f8d345e746605400305cbf1f20511eb47349ed1b82282671a125044353393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Area Under Curve</topic><topic>Breast cancer</topic><topic>Breast Density</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Cancer screening</topic><topic>Diagnosis</topic><topic>Drunk driving</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Mammary Glands, Human - diagnostic imaging</topic><topic>Mammary Glands, Human - pathology</topic><topic>Mammography</topic><topic>Mass Screening</topic><topic>Medical imaging equipment</topic><topic>Medical screening</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Oncology</topic><topic>Preclinical Study</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Tomography</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bu, Yangyang</creatorcontrib><creatorcontrib>Xia, Jun</creatorcontrib><creatorcontrib>Joseph, Bobby</creatorcontrib><creatorcontrib>Zhao, Xianjing</creatorcontrib><creatorcontrib>Xu, Maosheng</creatorcontrib><creatorcontrib>Yu, Yingxing</creatorcontrib><creatorcontrib>Qi, Shouliang</creatorcontrib><creatorcontrib>Shah, Kamran A.</creatorcontrib><creatorcontrib>Wang, Shiwei</creatorcontrib><creatorcontrib>Hu, Jiani</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bu, Yangyang</au><au>Xia, Jun</au><au>Joseph, Bobby</au><au>Zhao, Xianjing</au><au>Xu, Maosheng</au><au>Yu, Yingxing</au><au>Qi, Shouliang</au><au>Shah, Kamran A.</au><au>Wang, Shiwei</au><au>Hu, Jiani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-contrast MRI for breast screening: preliminary study on detectability of benign and malignant lesions in women with dense breasts</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>177</volume><issue>3</issue><spage>629</spage><epage>639</epage><pages>629-639</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><abstract>Purpose
The importance of breast cancer screening has long been known. Unfortunately, there is no imaging modality for screening women with dense breasts that is both sensitive and without concerns regarding potential side effects. The purpose of this study is to explore the possibility of combined diffusion-weighted imaging and turbo inversion recovery magnitude MRI (DWI + TIRM) to overcome the difficulty of detection sensitivity and safety.
Methods
One hundred and seventy-six breast lesions from 166 women with dense breasts were retrospectively evaluated. The lesion visibility, area under the curve (AUC), sensitivity and specificity of cancer detection by MG, DWI + TIRM, and clinical MRI were evaluated and compared. MG plus clinical MRI served as the gold standard for lesion detection and pathology served as the gold standard for cancer detection.
Results
Lesion visibility of DWI + TIRM (96.6%) was significantly superior to MG (67.6%) in women with dense breasts (
p
< 0.001). There was no significant difference compared with clinical MRI. DWI + TIRM showed higher accuracy (AUC = 0.935) and sensitivity (93.68%) for breast cancer detection than MG (AUC = 0.783, sensitivity = 46.32%), but was comparable to clinical MRI (AUC = 0.944, sensitivity = 93.68%). The specificity of DWI + TIRM (83.95%) was lower than MG (98.77%), but higher than clinical MRI (77.78%).
Conclusions
DWI combined with TIRM could be a safe, sensitive, and practical alternative for screening women with dense breasts.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31325074</pmid><doi>10.1007/s10549-019-05342-5</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2928-3169</orcidid></addata></record> |
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| ispartof | Breast cancer research and treatment, 2019-10, Vol.177 (3), p.629-639 |
| issn | 0167-6806 1573-7217 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Area Under Curve Breast cancer Breast Density Breast Neoplasms - diagnostic imaging Breast Neoplasms - epidemiology Cancer Cancer research Cancer screening Diagnosis Drunk driving Female Humans Magnetic Resonance Imaging Mammary Glands, Human - diagnostic imaging Mammary Glands, Human - pathology Mammography Mass Screening Medical imaging equipment Medical screening Medicine Medicine & Public Health Middle Aged Neoplasm Grading Oncology Preclinical Study Retrospective Studies ROC Curve Sensitivity and Specificity Tomography Women Young Adult |
| title | Non-contrast MRI for breast screening: preliminary study on detectability of benign and malignant lesions in women with dense breasts |
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