Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota

Inflammation, injury, and infection up-regulate expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in the intestinal epithelium. We studied the effects of cell-specific IDO1 expression in the epithelium at baseline and during intestinal inflammation in mice. We gen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2019-10, Vol.157 (4), p.1093-1108.e11
Hauptverfasser:	Alvarado, David M., Chen, Baosheng, Iticovici, Micah, Thaker, Ameet I., Dai, Nattalie, VanDussen, Kelli L., Shaikh, Nurmohammad, Lim, Chai K., Guillemin, Gilles J., Tarr, Phillip I., Ciorba, Matthew A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria - metabolism Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Case-Control Studies Cell Differentiation Cell Line Cell Lineage Disease Models, Animal Epithelial Cells - enzymology Epithelial Cells - microbiology Epithelial Cells - pathology Gastrointestinal Microbiome Genotype Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - deficiency Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Inflammatory Bowel Diseases - enzymology Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - microbiology Inflammatory Bowel Diseases - pathology Intestinal Mucosa - enzymology Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Kynurenine Metabolism Mice, Knockout Microbiome Organoids Phenotype Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Receptors, Notch - genetics Receptors, Notch - metabolism Secretory Pathway Signal Transduction Stem Cells - enzymology Stem Cells - microbiology Stem Cells - pathology Ulcerative Colitis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!