Characterization of 3 PET Tracers for Quantification of Mitochondrial and Synaptic Function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, and 11C-UCB-J

Mitochondrial complex 1 is involved in maintaining brain bioenergetics; σ-1 receptor responds to neuronal stress; and synaptic vesicle protein 2A reflects synaptic integrity. Expression of each of these proteins is altered in neurodegenerative diseases. Here, we characterize the kinetic behavior of...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of nuclear medicine (1978) 2020-01, Vol.61 (1), p.96-103
Hauptverfasser:	Mansur, Ayla, Rabiner, Eugenii A, Comley, Robert A, Lewis, Yvonne, Middleton, Lefkos T, Huiban, Mickael, Passchier, Jan, Tsukada, Hideo, Gunn, Roger N
Format:	Artikel
Sprache:	eng
Schlagworte:	Age factors Bioenergetics Brain In vivo methods and tests Mitochondria Neurodegenerative diseases Positron emission Positron emission tomography Proteins Radioisotopes Tomography Tracers
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!