Hedyotis diffusa Willd. inhibits VEGF‑C‑mediated lymphangiogenesis in colorectal cancer via multiple signaling pathways

Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies worldwide. For patients diagnosed with the presence of metastatic disease, surgery is not suitable for the majority of them. Lymphangiogenesis is a key factor during cancer metastasis and is regulated by vascular endothelial...

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Veröffentlicht in:	Oncology reports 2019-09, Vol.42 (3), p.1225-1236
Hauptverfasser:	Li, Huang, Lai, Zijun, Yang, Hong, Peng, Jun, Chen, Youqin, Lin, Jiumao
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Biotechnology industry Cancer metastasis Cancer therapies Cancer treatment Cell adhesion & migration Cell growth Cell Movement Cell Proliferation Colorectal cancer Colorectal Neoplasms - blood supply Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Endothelial growth factors Endothelium Enzyme-linked immunosorbent assay Ethanol Family Gene Expression Regulation, Neoplastic - drug effects Health aspects Hedyotis - chemistry Humans Kinases Lymphangiogenesis - drug effects Mediation Metastasis Mortality Plant Extracts - pharmacology Protein expression Proteins Scientific equipment industry Signal Transduction - drug effects Surgery Tumor Cells, Cultured Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor C - metabolism Wound care Wound healing
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