Nicorandil prevents doxorubicin-induced human umbilical vein endothelial cell apoptosis

Nicorandil is an adenosine triphosphate-sensitive potassium channel opener with additional antioxidant properties. Doxorubicin (DOX) is an anticancer drug that exerts oxidation-mediated adverse cardiovascular effects. This study examined the effects of nicorandil on DOX-induced cytotoxicity in human...

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Veröffentlicht in:	European journal of pharmacology 2019-09, Vol.859, p.172542-172542, Article 172542
Hauptverfasser:	Chen, Chun-Chao, Hong, Hong-Jye, Hao, Wen-Rui, Cheng, Tzu-Hurng, Liu, Ju-Chi, Sung, Li-Chin
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - metabolism Antioxidants - metabolism Apoptosis Apoptosis - drug effects Cytoprotection - drug effects Doxorubicin Doxorubicin - adverse effects Endothelial cells Gene Expression Regulation - drug effects Heme Oxygenase-1 - metabolism Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Intracellular Space - drug effects Intracellular Space - metabolism NF-E2-Related Factor 2 - metabolism Nicorandil Nicorandil - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism
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