Modest Blood-Brain Barrier Permeability of the Cyclodextrin Kleptose: Modification by Efflux and Luminal Surface Binding

Cyclodextrins (CDs) have a variety of uses from acting as excipients to aiding the ability of lipid soluble drugs to cross the blood-brain barrier (BBB). They are being investigated as an active pharmaceutical ingredient, most recently for the treatment of Niemann-Pick disease, a lysosomal storage d...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2019-10, Vol.371 (1), p.121-129
Hauptverfasser:	Banks, W A, Engelke, Kory, Hansen, Kim M, Bullock, Kristin M, Calias, Pericles
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin - pharmacokinetics Animals Blood-Brain Barrier - metabolism Capillary Permeability Male Mice
Online-Zugang:	Volltext
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