Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses

DNA viruses typically eject genomic DNA into the nuclei of host cells after entry. It is unclear, however, how nuclear pathogen-derived DNA triggers innate immune responses. We report that heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) recognizes pathogenic DNA and amplifies interferon-α/β...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2019-08, Vol.365 (6454), p.656-656
Hauptverfasser:	Wang, Lei, Wen, Mingyue, Cao, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine - analogs & derivatives Adenosine - metabolism Amplification Animals Arginine Binding Body fat Cell Nucleus - immunology Cell Nucleus - virology Cytokines Cytoplasm Cytoplasm - metabolism Cytosol Demethylation Deoxyribonucleic acid Dimerization Dimers DNA DNA Virus Infections - immunology DNA viruses DNA, Viral - immunology Eukaryotes Feedback (Response) Gene expression Genes HEK293 Cells Herpes simplex Herpes viruses Herpesvirus 1, Human - immunology Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism Humans Immune response Immune system Immunity, Innate Infections Inflammation Innate immunity Interferon Interferon regulatory factor Interferon Regulatory Factor-3 Interferon-alpha - metabolism Interferon-beta - metabolism Interleukin 6 Jumonji Domain-Containing Histone Demethylases - metabolism Kinases Macrophages Membrane Proteins - metabolism Methylation Mice Mice, Knockout Microorganisms Mutation N6-methyladenosine Nuclear Proteins - metabolism Nuclei Nuclei (cytology) Nucleic acids Nucleotidyltransferases - metabolism Obesity Pathogens Phosphoproteins - metabolism Protein Transport Protein-Serine-Threonine Kinases - metabolism Protein-tyrosine kinase Proteins RAW 264.7 Cells RESEARCH ARTICLE SUMMARY RNA viruses Sensors Signal transduction Translocation Tyrosine Viral infections Viruses α-Interferon β-Interferon γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!