Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen–anagen transformation

Summary Background The signals that induce anagen (growth) in ‘quiescent’ human telogen hair follicles (HFs) are as yet unknown. Their identification promises better targeted therapeutic hair growth interventions. Objectives Recognizing the central role of Wnt signalling in hair biology, the aim was...

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Veröffentlicht in:	British journal of dermatology (1951) 2020-05, Vol.182 (5), p.1184-1193
Hauptverfasser:	Hawkshaw, N.J., Hardman, J.A., Alam, M., Jimenez, F., Paus, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Alopecia Alopecia - genetics Animals Antagonists Autocrine signalling Cell activation Drug development Epithelium Follicles Frizzled protein Frizzled-related protein 1 Gene expression Genetic transformation Hair Hair Follicle Humans Hybridization Ligands Mice Scalp Signal transduction Stem cell transplantation Stem cells Therapeutic applications Wnt protein Wnt Proteins - genetics Wnt Signaling Pathway
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