Test–retest repeatability of the pattern electroretinogram and flicker electroretinogram
Purpose To evaluate the repeatability of the steady-state pattern electroretinogram (PERG) and full-field flicker electroretinogram (Flicker ERG) protocols, delivered by the office-based Neuro Optic Vision Assessment (NOVA)™ testing platform, in healthy subjects. Methods Healthy individuals underwen...
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| Veröffentlicht in: | Documenta ophthalmologica 2019-12, Vol.139 (3), p.185-195 |
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| creator | Resende, Arthur F. Sanvicente, Carina T. Eshraghi, Hamoon Garcia, Alberto Pickel, Kassandra Zhang, Qiang Waisbourd, Michael Jay Katz, L. |
| description | Purpose
To evaluate the repeatability of the steady-state pattern electroretinogram (PERG) and full-field flicker electroretinogram (Flicker ERG) protocols, delivered by the office-based Neuro Optic Vision Assessment (NOVA)™ testing platform, in healthy subjects.
Methods
Healthy individuals underwent PERG (16° and 24°) and Flicker ERG [fixed luminance (FL) and multi-luminance (ML)] testing protocols. Test–retest repeatability of protocols was calculated using intra-class correlation coefficients (ICC). Reference values of the parameters of the aforementioned tests were also calculated.
Results
The ICCs for the PERG parameters ranged from 0.793 to 0.911 (
p
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| doi_str_mv | 10.1007/s10633-019-09707-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2259358817</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2258471135</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-78ccca65cf444d93d404c56512b4c6b879743bd46074a557905b9d913d4b24df3</originalsourceid><addsrcrecordid>eNp9kDtOAzEQhi0EIiFwAQq0Eg2Nwc_1ukQRLykSTWhoLK_XGzbsC9sp0nEHbshJcNgAEkhUY2m--Wf8AXCM0TlGSFx4jFJKIcISIimQgHwHjDEXFJKUkF0wRggTyFiWjsCB90uEIoazfTCimGIiGRuDx7n14f31zdkQH4mzvdVB51VdhXXSlUl4skmvQ7CuTWxtTXBdRKu2WzjdJLotkrKuzLN1f7uHYK_UtbdH2zoBD9dX8-ktnN3f3E0vZ9BQwQMUmTFGp9yUjLFC0oIhZnjKMcmZSfNMSMFoXrAUCaY5FxLxXBYSRzAnrCjpBJwNub3rXlbxF6qpvLF1rVvbrbwihEvKswyLiJ7-QpfdyrXxug2VMYEx5ZEiA2Vc572zpepd1Wi3VhipjXk1mFfRvPo0rzZDJ9voVd7Y4nvkS3UE6AD42GoX1v3s_if2A5tcj8w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2258471135</pqid></control><display><type>article</type><title>Test–retest repeatability of the pattern electroretinogram and flicker electroretinogram</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Resende, Arthur F. ; Sanvicente, Carina T. ; Eshraghi, Hamoon ; Garcia, Alberto ; Pickel, Kassandra ; Zhang, Qiang ; Waisbourd, Michael ; Jay Katz, L.</creator><creatorcontrib>Resende, Arthur F. ; Sanvicente, Carina T. ; Eshraghi, Hamoon ; Garcia, Alberto ; Pickel, Kassandra ; Zhang, Qiang ; Waisbourd, Michael ; Jay Katz, L.</creatorcontrib><description>Purpose
To evaluate the repeatability of the steady-state pattern electroretinogram (PERG) and full-field flicker electroretinogram (Flicker ERG) protocols, delivered by the office-based Neuro Optic Vision Assessment (NOVA)™ testing platform, in healthy subjects.
Methods
Healthy individuals underwent PERG (16° and 24°) and Flicker ERG [fixed luminance (FL) and multi-luminance (ML)] testing protocols. Test–retest repeatability of protocols was calculated using intra-class correlation coefficients (ICC). Reference values of the parameters of the aforementioned tests were also calculated.
Results
The ICCs for the PERG parameters ranged from 0.793 to 0.911 (
p
< 0.001). The ICCs for the Flicker ERG parameters ranged from 0.968 to 0.994 (
p
< 0.001). A linear regression analysis was applied to assess the impact of age on ERG responses. Age had a significant impact on all PERG parameters (16° or 24°). The phase response of the FL Flicker ERG significantly decreased with age (
β
= − 0.837,
p
≤ 0.001). The FL Flicker ERG Magnitude was also impacted with a significant quadratic effect of age (
β
= − 0.0047,
p
= 0.0004). Similarly, the Phase Area Under the Curve (Phase AUC) of the ML Flicker ERG significantly declined with age (
β
= − 0.007,
p
= 0.009), and the impact on the Magnitude AUC was significant as well, with a negative quadratic age effect.
Conclusions
The PERG and Flicker ERG protocols, delivered by an office-based testing platform, were shown to have good-to-excellent test–retest repeatability when tests were performed in the same order and in immediate succession.</description><identifier>ISSN: 0012-4486</identifier><identifier>EISSN: 1573-2622</identifier><identifier>DOI: 10.1007/s10633-019-09707-5</identifier><identifier>PMID: 31312944</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Aging - physiology ; Cross-Sectional Studies ; Electroretinograms ; Electroretinography - methods ; Electroretinography - standards ; Female ; Healthy Volunteers ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Ophthalmology ; Original Research Article ; Prospective Studies ; Reference Values ; Reproducibility of Results ; Retina - physiology ; Young Adult</subject><ispartof>Documenta ophthalmologica, 2019-12, Vol.139 (3), p.185-195</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Documenta Ophthalmologica is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-78ccca65cf444d93d404c56512b4c6b879743bd46074a557905b9d913d4b24df3</citedby><cites>FETCH-LOGICAL-c375t-78ccca65cf444d93d404c56512b4c6b879743bd46074a557905b9d913d4b24df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10633-019-09707-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10633-019-09707-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31312944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Resende, Arthur F.</creatorcontrib><creatorcontrib>Sanvicente, Carina T.</creatorcontrib><creatorcontrib>Eshraghi, Hamoon</creatorcontrib><creatorcontrib>Garcia, Alberto</creatorcontrib><creatorcontrib>Pickel, Kassandra</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Waisbourd, Michael</creatorcontrib><creatorcontrib>Jay Katz, L.</creatorcontrib><title>Test–retest repeatability of the pattern electroretinogram and flicker electroretinogram</title><title>Documenta ophthalmologica</title><addtitle>Doc Ophthalmol</addtitle><addtitle>Doc Ophthalmol</addtitle><description>Purpose
To evaluate the repeatability of the steady-state pattern electroretinogram (PERG) and full-field flicker electroretinogram (Flicker ERG) protocols, delivered by the office-based Neuro Optic Vision Assessment (NOVA)™ testing platform, in healthy subjects.
Methods
Healthy individuals underwent PERG (16° and 24°) and Flicker ERG [fixed luminance (FL) and multi-luminance (ML)] testing protocols. Test–retest repeatability of protocols was calculated using intra-class correlation coefficients (ICC). Reference values of the parameters of the aforementioned tests were also calculated.
Results
The ICCs for the PERG parameters ranged from 0.793 to 0.911 (
p
< 0.001). The ICCs for the Flicker ERG parameters ranged from 0.968 to 0.994 (
p
< 0.001). A linear regression analysis was applied to assess the impact of age on ERG responses. Age had a significant impact on all PERG parameters (16° or 24°). The phase response of the FL Flicker ERG significantly decreased with age (
β
= − 0.837,
p
≤ 0.001). The FL Flicker ERG Magnitude was also impacted with a significant quadratic effect of age (
β
= − 0.0047,
p
= 0.0004). Similarly, the Phase Area Under the Curve (Phase AUC) of the ML Flicker ERG significantly declined with age (
β
= − 0.007,
p
= 0.009), and the impact on the Magnitude AUC was significant as well, with a negative quadratic age effect.
Conclusions
The PERG and Flicker ERG protocols, delivered by an office-based testing platform, were shown to have good-to-excellent test–retest repeatability when tests were performed in the same order and in immediate succession.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Electroretinograms</subject><subject>Electroretinography - methods</subject><subject>Electroretinography - standards</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Original Research Article</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Retina - physiology</subject><subject>Young Adult</subject><issn>0012-4486</issn><issn>1573-2622</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kDtOAzEQhi0EIiFwAQq0Eg2Nwc_1ukQRLykSTWhoLK_XGzbsC9sp0nEHbshJcNgAEkhUY2m--Wf8AXCM0TlGSFx4jFJKIcISIimQgHwHjDEXFJKUkF0wRggTyFiWjsCB90uEIoazfTCimGIiGRuDx7n14f31zdkQH4mzvdVB51VdhXXSlUl4skmvQ7CuTWxtTXBdRKu2WzjdJLotkrKuzLN1f7uHYK_UtbdH2zoBD9dX8-ktnN3f3E0vZ9BQwQMUmTFGp9yUjLFC0oIhZnjKMcmZSfNMSMFoXrAUCaY5FxLxXBYSRzAnrCjpBJwNub3rXlbxF6qpvLF1rVvbrbwihEvKswyLiJ7-QpfdyrXxug2VMYEx5ZEiA2Vc572zpepd1Wi3VhipjXk1mFfRvPo0rzZDJ9voVd7Y4nvkS3UE6AD42GoX1v3s_if2A5tcj8w</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Resende, Arthur F.</creator><creator>Sanvicente, Carina T.</creator><creator>Eshraghi, Hamoon</creator><creator>Garcia, Alberto</creator><creator>Pickel, Kassandra</creator><creator>Zhang, Qiang</creator><creator>Waisbourd, Michael</creator><creator>Jay Katz, L.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20191201</creationdate><title>Test–retest repeatability of the pattern electroretinogram and flicker electroretinogram</title><author>Resende, Arthur F. ; Sanvicente, Carina T. ; Eshraghi, Hamoon ; Garcia, Alberto ; Pickel, Kassandra ; Zhang, Qiang ; Waisbourd, Michael ; Jay Katz, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-78ccca65cf444d93d404c56512b4c6b879743bd46074a557905b9d913d4b24df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Electroretinograms</topic><topic>Electroretinography - methods</topic><topic>Electroretinography - standards</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Original Research Article</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Retina - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Resende, Arthur F.</creatorcontrib><creatorcontrib>Sanvicente, Carina T.</creatorcontrib><creatorcontrib>Eshraghi, Hamoon</creatorcontrib><creatorcontrib>Garcia, Alberto</creatorcontrib><creatorcontrib>Pickel, Kassandra</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Waisbourd, Michael</creatorcontrib><creatorcontrib>Jay Katz, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Documenta ophthalmologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Resende, Arthur F.</au><au>Sanvicente, Carina T.</au><au>Eshraghi, Hamoon</au><au>Garcia, Alberto</au><au>Pickel, Kassandra</au><au>Zhang, Qiang</au><au>Waisbourd, Michael</au><au>Jay Katz, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Test–retest repeatability of the pattern electroretinogram and flicker electroretinogram</atitle><jtitle>Documenta ophthalmologica</jtitle><stitle>Doc Ophthalmol</stitle><addtitle>Doc Ophthalmol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>139</volume><issue>3</issue><spage>185</spage><epage>195</epage><pages>185-195</pages><issn>0012-4486</issn><eissn>1573-2622</eissn><abstract>Purpose
To evaluate the repeatability of the steady-state pattern electroretinogram (PERG) and full-field flicker electroretinogram (Flicker ERG) protocols, delivered by the office-based Neuro Optic Vision Assessment (NOVA)™ testing platform, in healthy subjects.
Methods
Healthy individuals underwent PERG (16° and 24°) and Flicker ERG [fixed luminance (FL) and multi-luminance (ML)] testing protocols. Test–retest repeatability of protocols was calculated using intra-class correlation coefficients (ICC). Reference values of the parameters of the aforementioned tests were also calculated.
Results
The ICCs for the PERG parameters ranged from 0.793 to 0.911 (
p
< 0.001). The ICCs for the Flicker ERG parameters ranged from 0.968 to 0.994 (
p
< 0.001). A linear regression analysis was applied to assess the impact of age on ERG responses. Age had a significant impact on all PERG parameters (16° or 24°). The phase response of the FL Flicker ERG significantly decreased with age (
β
= − 0.837,
p
≤ 0.001). The FL Flicker ERG Magnitude was also impacted with a significant quadratic effect of age (
β
= − 0.0047,
p
= 0.0004). Similarly, the Phase Area Under the Curve (Phase AUC) of the ML Flicker ERG significantly declined with age (
β
= − 0.007,
p
= 0.009), and the impact on the Magnitude AUC was significant as well, with a negative quadratic age effect.
Conclusions
The PERG and Flicker ERG protocols, delivered by an office-based testing platform, were shown to have good-to-excellent test–retest repeatability when tests were performed in the same order and in immediate succession.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31312944</pmid><doi>10.1007/s10633-019-09707-5</doi><tpages>11</tpages></addata></record> |
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| ispartof | Documenta ophthalmologica, 2019-12, Vol.139 (3), p.185-195 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Age Aged Aged, 80 and over Aging - physiology Cross-Sectional Studies Electroretinograms Electroretinography - methods Electroretinography - standards Female Healthy Volunteers Humans Male Medicine Medicine & Public Health Middle Aged Ophthalmology Original Research Article Prospective Studies Reference Values Reproducibility of Results Retina - physiology Young Adult |
| title | Test–retest repeatability of the pattern electroretinogram and flicker electroretinogram |
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