Lymphatic clearance is the main drainage route of lamotrigine‐loaded micelles following delivery to the brain

Objectives This study aimed to investigate the clearance pathways of lamotrigine (LTG)‐loaded micelles by intranasal administration and intracerebral injection in the brain and whether nanoparticles can induce the inflammation promoted by interleukin‐6 (IL‐6), accelerating the phagocytosis of drug p...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2019-10, Vol.71 (10), p.1488-1496
Hauptverfasser:	Yan, Jiaqi, Ren, Jialin, Zhu, Yu, Lin, Yanzhen, Chen, Gang, Hou, Dongzhi, Lv, Zhufen, Zhou, Jiaxin, Chen, Yanzhong, Yang, Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	administration route Administration, Intranasal Animals Anticonvulsants - administration & dosage Anticonvulsants - metabolism Biopsy Brain Brain - metabolism Drainage - methods drug clearance Enzyme-linked immunosorbent assay Injection Intranasal administration Jugular vein Lamotrigine Lamotrigine - administration & dosage Lamotrigine - metabolism lamotrigine micelles Lymph nodes Lymph Nodes - metabolism Lymphatic system Lymphatic System - metabolism meningeal lymphatics Micelles Nanoparticles Nanoparticles - administration & dosage Phagocytosis Rats Rats, Sprague-Dawley Tissues Veins Wound drainage
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