Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis
Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation. Methods: We searched the Medlin...
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| Veröffentlicht in: | Modern rheumatology 2020-09, Vol.30 (5), p.894-899 |
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| description | Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation.
Methods: We searched the Medline, Embase, and Cochrane databases, performed a meta-analysis comparing RDW, PLR, and MPV in patients with AS to controls, and examined correlation coefficients between RDW, PLR, and MPV and C-reactive protein (CRP).
Results: Eleven studies were included in this meta-analysis, which revealed that RDW was significantly higher in the AS group than in the control group (standardized mean difference (SMD) = 0.687, 95% confidence interval (CI) = 0.110-1.265, p = .020). However, PLR was not significantly higher in the AS group than in the control group (SMD = 0.197, 95% CI = -0.045-0.439, p = .111). No evidence of elevated MPV in the AS group was found (SMD = -0.005, 95% CI = -0.411-0.400, p = .979). Meta-analysis of correlation coefficients revealed that RDW was positively associated with CRP (correlation coefficient = 0.327, 95% CI = 0.214-0.431, p |
| doi_str_mv | 10.1080/14397595.2019.1645373 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_2259354616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2259354616</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-8b35cfa8e38530200566cd7c78dabad2f4c07d30e3679f6fda17f590479dc3273</originalsourceid><addsrcrecordid>eNp9kU1vFSEYhYnR2A_9CRqWLjq3MAzD4Mqm0WrSpEmja8Llw4syMAJjM7_IvynTe2-XDQvIy3Pek5wDwDuMNhgN6BJ3hDPK6aZFmG9w31HCyAtwus4b1iP-8viu0Ak4y_kXQoTygb8GJwTXU5lT8O_eaKiM91C7XJLbzsXFAB-cLrsLOHlZjDelKbHxyzjtolqKgUlW6ALKoOFoZHjC4N_o59FAF-rf78XH7MJPmKcY9OJdcflRUnbGJahiSsavi0KudmVXVdbLcXwcfYRXdXWRjQzSL9nlN-CVlT6bt4f7HPz48vn79dfm9u7m2_XVbaMIR6UZtoQqKwdDBkpQixDte6WZYoOWW6lb2ynENEGG9Izb3mqJmaUcdYxrRVpGzsGH_d4pxT-zyUWMLq_5yGDinEXbUk5o1-O-onSPqhRzTsaKKblRpkVgJNaOxLEjsXYkDh1V3fuDxbwdjX5SHUupwKc9UBOJaZQPMXktiqyBJptkUC5X-FmP_-NcpSU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2259354616</pqid></control><display><type>article</type><title>Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><creator>Song, Gwan Gyu ; Lee, Young Ho</creator><creatorcontrib>Song, Gwan Gyu ; Lee, Young Ho</creatorcontrib><description>Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation.
Methods: We searched the Medline, Embase, and Cochrane databases, performed a meta-analysis comparing RDW, PLR, and MPV in patients with AS to controls, and examined correlation coefficients between RDW, PLR, and MPV and C-reactive protein (CRP).
Results: Eleven studies were included in this meta-analysis, which revealed that RDW was significantly higher in the AS group than in the control group (standardized mean difference (SMD) = 0.687, 95% confidence interval (CI) = 0.110-1.265, p = .020). However, PLR was not significantly higher in the AS group than in the control group (SMD = 0.197, 95% CI = -0.045-0.439, p = .111). No evidence of elevated MPV in the AS group was found (SMD = -0.005, 95% CI = -0.411-0.400, p = .979). Meta-analysis of correlation coefficients revealed that RDW was positively associated with CRP (correlation coefficient = 0.327, 95% CI = 0.214-0.431, p < .001). PLR was positively associated with CRP (correlation coefficient = 0.444, 95% CI = 0.283-0.581, p < .001). In addition, the meta-analysis showed a correlation between MPV and CRP (correlation coefficient = 0.217, 95% CI = 0.080-0.346, p = .002).
Conclusion: This meta-analysis demonstrated that RDW is higher in patients with AS, and a significant positive correlation exists between RDW, PLR, and MPV and CRP.</description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.1080/14397595.2019.1645373</identifier><identifier>PMID: 31313609</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>ankylosing spondylitis ; Blood cell count ; C-Reactive Protein - analysis ; Erythrocyte Indices ; Humans ; inflammation ; Lymphocyte Count ; Mean Platelet Volume ; Platelet Count ; relationship ; Spondylitis, Ankylosing - blood</subject><ispartof>Modern rheumatology, 2020-09, Vol.30 (5), p.894-899</ispartof><rights>2019 Japan College of Rheumatology 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-8b35cfa8e38530200566cd7c78dabad2f4c07d30e3679f6fda17f590479dc3273</citedby><cites>FETCH-LOGICAL-c390t-8b35cfa8e38530200566cd7c78dabad2f4c07d30e3679f6fda17f590479dc3273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31313609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Gwan Gyu</creatorcontrib><creatorcontrib>Lee, Young Ho</creatorcontrib><title>Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis</title><title>Modern rheumatology</title><addtitle>Mod Rheumatol</addtitle><description>Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation.
Methods: We searched the Medline, Embase, and Cochrane databases, performed a meta-analysis comparing RDW, PLR, and MPV in patients with AS to controls, and examined correlation coefficients between RDW, PLR, and MPV and C-reactive protein (CRP).
Results: Eleven studies were included in this meta-analysis, which revealed that RDW was significantly higher in the AS group than in the control group (standardized mean difference (SMD) = 0.687, 95% confidence interval (CI) = 0.110-1.265, p = .020). However, PLR was not significantly higher in the AS group than in the control group (SMD = 0.197, 95% CI = -0.045-0.439, p = .111). No evidence of elevated MPV in the AS group was found (SMD = -0.005, 95% CI = -0.411-0.400, p = .979). Meta-analysis of correlation coefficients revealed that RDW was positively associated with CRP (correlation coefficient = 0.327, 95% CI = 0.214-0.431, p < .001). PLR was positively associated with CRP (correlation coefficient = 0.444, 95% CI = 0.283-0.581, p < .001). In addition, the meta-analysis showed a correlation between MPV and CRP (correlation coefficient = 0.217, 95% CI = 0.080-0.346, p = .002).
Conclusion: This meta-analysis demonstrated that RDW is higher in patients with AS, and a significant positive correlation exists between RDW, PLR, and MPV and CRP.</description><subject>ankylosing spondylitis</subject><subject>Blood cell count</subject><subject>C-Reactive Protein - analysis</subject><subject>Erythrocyte Indices</subject><subject>Humans</subject><subject>inflammation</subject><subject>Lymphocyte Count</subject><subject>Mean Platelet Volume</subject><subject>Platelet Count</subject><subject>relationship</subject><subject>Spondylitis, Ankylosing - blood</subject><issn>1439-7595</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vFSEYhYnR2A_9CRqWLjq3MAzD4Mqm0WrSpEmja8Llw4syMAJjM7_IvynTe2-XDQvIy3Pek5wDwDuMNhgN6BJ3hDPK6aZFmG9w31HCyAtwus4b1iP-8viu0Ak4y_kXQoTygb8GJwTXU5lT8O_eaKiM91C7XJLbzsXFAB-cLrsLOHlZjDelKbHxyzjtolqKgUlW6ALKoOFoZHjC4N_o59FAF-rf78XH7MJPmKcY9OJdcflRUnbGJahiSsavi0KudmVXVdbLcXwcfYRXdXWRjQzSL9nlN-CVlT6bt4f7HPz48vn79dfm9u7m2_XVbaMIR6UZtoQqKwdDBkpQixDte6WZYoOWW6lb2ynENEGG9Izb3mqJmaUcdYxrRVpGzsGH_d4pxT-zyUWMLq_5yGDinEXbUk5o1-O-onSPqhRzTsaKKblRpkVgJNaOxLEjsXYkDh1V3fuDxbwdjX5SHUupwKc9UBOJaZQPMXktiqyBJptkUC5X-FmP_-NcpSU</recordid><startdate>20200902</startdate><enddate>20200902</enddate><creator>Song, Gwan Gyu</creator><creator>Lee, Young Ho</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200902</creationdate><title>Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis</title><author>Song, Gwan Gyu ; Lee, Young Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-8b35cfa8e38530200566cd7c78dabad2f4c07d30e3679f6fda17f590479dc3273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ankylosing spondylitis</topic><topic>Blood cell count</topic><topic>C-Reactive Protein - analysis</topic><topic>Erythrocyte Indices</topic><topic>Humans</topic><topic>inflammation</topic><topic>Lymphocyte Count</topic><topic>Mean Platelet Volume</topic><topic>Platelet Count</topic><topic>relationship</topic><topic>Spondylitis, Ankylosing - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Gwan Gyu</creatorcontrib><creatorcontrib>Lee, Young Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Gwan Gyu</au><au>Lee, Young Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis</atitle><jtitle>Modern rheumatology</jtitle><addtitle>Mod Rheumatol</addtitle><date>2020-09-02</date><risdate>2020</risdate><volume>30</volume><issue>5</issue><spage>894</spage><epage>899</epage><pages>894-899</pages><issn>1439-7595</issn><eissn>1439-7609</eissn><abstract>Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation.
Methods: We searched the Medline, Embase, and Cochrane databases, performed a meta-analysis comparing RDW, PLR, and MPV in patients with AS to controls, and examined correlation coefficients between RDW, PLR, and MPV and C-reactive protein (CRP).
Results: Eleven studies were included in this meta-analysis, which revealed that RDW was significantly higher in the AS group than in the control group (standardized mean difference (SMD) = 0.687, 95% confidence interval (CI) = 0.110-1.265, p = .020). However, PLR was not significantly higher in the AS group than in the control group (SMD = 0.197, 95% CI = -0.045-0.439, p = .111). No evidence of elevated MPV in the AS group was found (SMD = -0.005, 95% CI = -0.411-0.400, p = .979). Meta-analysis of correlation coefficients revealed that RDW was positively associated with CRP (correlation coefficient = 0.327, 95% CI = 0.214-0.431, p < .001). PLR was positively associated with CRP (correlation coefficient = 0.444, 95% CI = 0.283-0.581, p < .001). In addition, the meta-analysis showed a correlation between MPV and CRP (correlation coefficient = 0.217, 95% CI = 0.080-0.346, p = .002).
Conclusion: This meta-analysis demonstrated that RDW is higher in patients with AS, and a significant positive correlation exists between RDW, PLR, and MPV and CRP.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>31313609</pmid><doi>10.1080/14397595.2019.1645373</doi><tpages>6</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | ankylosing spondylitis Blood cell count C-Reactive Protein - analysis Erythrocyte Indices Humans inflammation Lymphocyte Count Mean Platelet Volume Platelet Count relationship Spondylitis, Ankylosing - blood |
| title | Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis |
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