Usefulness of immunohistochemistry for mismatch repair protein and microsatellite instability examination in adenocarcinoma and background endometrium of sporadic endometrial cancer cases

Aim Microsatellite instability (MSI), which reflects loss of DNA mismatch repair (MMR) activity, and immunohistochemistry (IHC) for MMR proteins are employed as screening examinations for Lynch syndrome (LS). Recent studies revealed that there is a population of MSI‐high tumors in sporadic endometri...

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Veröffentlicht in:	The journal of obstetrics and gynaecology research 2019-10, Vol.45 (10), p.2037-2042
Hauptverfasser:	Saeki, Harumi, Hlaing, May T., Horimoto, Yoshiya, Kajino, Kazunori, Ohtsuji, Naomi, Fujino, Kazunari, Terao, Yasuhisa, Hino, Okio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - enzymology Adenocarcinoma - genetics Colorectal cancer DNA Mismatch Repair DNA repair DNA Repair Enzymes - metabolism Endometrial cancer endometrial hyperplasia Endometrial Neoplasms - enzymology Endometrial Neoplasms - genetics Endometrium Endometrium - enzymology Female Genetic disorders Humans Hyperplasia Immunohistochemistry Lynch syndrome Menopause Microsatellite Instability Middle Aged Mismatch repair mismatch repair gene MLH1 protein MMR protein Proteins Tumorigenesis
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