Investigation of the permeation enhancer strategy on benzoylaconitine transdermal patch: the relationship between transdermal enhancement strength and physicochemical properties of permeation enhancer

Permeation enhancer strategy is used to develop Benzoylaconitine (BA) of high molecular weight (603.7 Da) into transdermal patch. The present study was to achieve a patch with good analgesic and anti-inflammatory effects and investigate the relationship between physicochemical parameters of enhancer...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2019-10, Vol.138, p.105009-105009, Article 105009
Hauptverfasser:	Liu, Chao, Farah, Nabil, Weng, Wei, Jiao, Baixin, Shen, Meiyue, Fang, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitine - analogs & derivatives Aconitine - pharmacology Administration, Cutaneous Animals Anti-Inflammatory Agents - pharmacology Benzoylaconitine Chemistry, Pharmaceutical - methods Hydrophobic and Hydrophilic Interactions - drug effects Male Mice Molecular interaction Permeability - drug effects Permeation enhancer Rats Rats, Wistar Skin - drug effects Skin Absorption - drug effects Spectroscopy, Fourier Transform Infrared - methods Surface tension Transdermal Patch
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